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- W2055848634 abstract "When intravascular platelet aggregation was induced by intravenous infusion of collagen extract, a temporary and marked increase in pulmonary vascular resistance (PVR) was observed. The number of circulating platelets was gradually reduced after the first few infusions of collagen. After 4–6 infusions of collagen the vascular response vanished, and the platelet count in arterial blood remained fairly stable. When a vasodilator was infused simultaneously with the collagen, the pressure response could be abolished. Histological examinations of lungs at the peak of a pressor response to collagen revealed aggregated platelets in small arterial vessels and capillaries. After many infusions larger vessels were found occluded by aggregated platelets. It is concluded that platelet aggregation in the blood arriving in the lung creates a strong vasoconstriction in the pulmonary vascular bed. This response is related to release of material from the platelets." @default.
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- W2055848634 date "1971-08-01" @default.
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- W2055848634 title "Effects on the Pulmonary Circulation of Suddenly Induced Intravascular Aggregation of Blood Platelets" @default.
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- W2055848634 doi "https://doi.org/10.1111/j.1748-1716.1971.tb05291.x" @default.
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