Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055854314> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2055854314 endingPage "189" @default.
- W2055854314 startingPage "183" @default.
- W2055854314 abstract "We investigated the penetration of rabbit IgG into the brain and spinal cord of newborn rat pups and compared them to mature rats using immunohistochemical and radionuclide techniques. Following intraperitoneal injection with rabbit IgG and perfusion fixation at various intervals, rabbit IgG was found to penetrate into the parenchyma of the neuraxis of neonatal rats and to establish much higher concentrations than was found in mature rats. Immunohistochemical studies revealed no evidence of significant extravasation of serum proteins from the vasculature. For any given survival interval studied, there was no significant difference in appearance and intensity of immunohistochemical staining or the amount of radiolabeled IgG measured between different areas of the brain and spinal cord. Electrophoresis of radioactive proteins extracted from the brains of neonatal rats injected with radiolabeled IgG confirmed that IgG penetrates into the brain parenchyma as the whole molecule. These results validate the use of systemically administered rabbit IgG for studies of brain development in neonatal rats. They also have implications for the pathogenesis of congenital central nervous system anomalies in which maternal autoimmune IgG may affect brain development after being transferred to the fetus or neonate." @default.
- W2055854314 created "2016-06-24" @default.
- W2055854314 creator A5015363963 @default.
- W2055854314 creator A5043648829 @default.
- W2055854314 date "1989-10-01" @default.
- W2055854314 modified "2023-10-17" @default.
- W2055854314 title "Time course of penetration of xenogeneic IgG into the central nervous system of the neonatal rat: an immunohistochemical and radionuclide tracer study" @default.
- W2055854314 cites W1591782996 @default.
- W2055854314 cites W1963482881 @default.
- W2055854314 cites W1964776691 @default.
- W2055854314 cites W1967262708 @default.
- W2055854314 cites W1972651408 @default.
- W2055854314 cites W1992014046 @default.
- W2055854314 cites W2007713701 @default.
- W2055854314 cites W2008796973 @default.
- W2055854314 cites W2013137776 @default.
- W2055854314 cites W2015029521 @default.
- W2055854314 cites W2017654980 @default.
- W2055854314 cites W2021900417 @default.
- W2055854314 cites W2028072764 @default.
- W2055854314 cites W2036223015 @default.
- W2055854314 cites W2040717366 @default.
- W2055854314 cites W2042930226 @default.
- W2055854314 cites W2052756986 @default.
- W2055854314 cites W2052877884 @default.
- W2055854314 cites W2081472976 @default.
- W2055854314 cites W2084595515 @default.
- W2055854314 cites W2160333751 @default.
- W2055854314 cites W2323852406 @default.
- W2055854314 cites W2408291787 @default.
- W2055854314 cites W68849013 @default.
- W2055854314 doi "https://doi.org/10.1016/0165-5728(89)90116-1" @default.
- W2055854314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2808690" @default.
- W2055854314 hasPublicationYear "1989" @default.
- W2055854314 type Work @default.
- W2055854314 sameAs 2055854314 @default.
- W2055854314 citedByCount "19" @default.
- W2055854314 countsByYear W20558543142012 @default.
- W2055854314 countsByYear W20558543142013 @default.
- W2055854314 countsByYear W20558543142016 @default.
- W2055854314 countsByYear W20558543142020 @default.
- W2055854314 crossrefType "journal-article" @default.
- W2055854314 hasAuthorship W2055854314A5015363963 @default.
- W2055854314 hasAuthorship W2055854314A5043648829 @default.
- W2055854314 hasConcept C118552586 @default.
- W2055854314 hasConcept C134018914 @default.
- W2055854314 hasConcept C142724271 @default.
- W2055854314 hasConcept C159654299 @default.
- W2055854314 hasConcept C172680121 @default.
- W2055854314 hasConcept C196822366 @default.
- W2055854314 hasConcept C203014093 @default.
- W2055854314 hasConcept C204232928 @default.
- W2055854314 hasConcept C2779234561 @default.
- W2055854314 hasConcept C2779540182 @default.
- W2055854314 hasConcept C2780775167 @default.
- W2055854314 hasConcept C2780898057 @default.
- W2055854314 hasConcept C529278444 @default.
- W2055854314 hasConcept C54355233 @default.
- W2055854314 hasConcept C71924100 @default.
- W2055854314 hasConcept C86803240 @default.
- W2055854314 hasConceptScore W2055854314C118552586 @default.
- W2055854314 hasConceptScore W2055854314C134018914 @default.
- W2055854314 hasConceptScore W2055854314C142724271 @default.
- W2055854314 hasConceptScore W2055854314C159654299 @default.
- W2055854314 hasConceptScore W2055854314C172680121 @default.
- W2055854314 hasConceptScore W2055854314C196822366 @default.
- W2055854314 hasConceptScore W2055854314C203014093 @default.
- W2055854314 hasConceptScore W2055854314C204232928 @default.
- W2055854314 hasConceptScore W2055854314C2779234561 @default.
- W2055854314 hasConceptScore W2055854314C2779540182 @default.
- W2055854314 hasConceptScore W2055854314C2780775167 @default.
- W2055854314 hasConceptScore W2055854314C2780898057 @default.
- W2055854314 hasConceptScore W2055854314C529278444 @default.
- W2055854314 hasConceptScore W2055854314C54355233 @default.
- W2055854314 hasConceptScore W2055854314C71924100 @default.
- W2055854314 hasConceptScore W2055854314C86803240 @default.
- W2055854314 hasIssue "3" @default.
- W2055854314 hasLocation W20558543141 @default.
- W2055854314 hasLocation W20558543142 @default.
- W2055854314 hasOpenAccess W2055854314 @default.
- W2055854314 hasPrimaryLocation W20558543141 @default.
- W2055854314 hasRelatedWork W118346583 @default.
- W2055854314 hasRelatedWork W1976490718 @default.
- W2055854314 hasRelatedWork W1984971014 @default.
- W2055854314 hasRelatedWork W2016888883 @default.
- W2055854314 hasRelatedWork W2055854314 @default.
- W2055854314 hasRelatedWork W2124618539 @default.
- W2055854314 hasRelatedWork W2155423194 @default.
- W2055854314 hasRelatedWork W2430428205 @default.
- W2055854314 hasRelatedWork W251578208 @default.
- W2055854314 hasRelatedWork W3109351399 @default.
- W2055854314 hasVolume "24" @default.
- W2055854314 isParatext "false" @default.
- W2055854314 isRetracted "false" @default.
- W2055854314 magId "2055854314" @default.
- W2055854314 workType "article" @default.