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- W2055870007 abstract "Myosin-V is a molecular motor that moves processively along its actin track. We have used a feedback-enhanced optical trap to examine the stepping kinetics of this movement. By analyzing the distribution of time periods separating discrete approximately 36-nm mechanical steps, we characterize the number and duration of rate-limiting biochemical transitions preceding each such step. These data show that myosin-V is a tightly coupled motor whose cycle time is limited by ADP release. On the basis of these results, we propose a model for myosin-V processivity." @default.
- W2055870007 created "2016-06-24" @default.
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- W2055870007 date "2000-08-15" @default.
- W2055870007 modified "2023-10-10" @default.
- W2055870007 title "Myosin-V stepping kinetics: A molecular model for processivity" @default.
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- W2055870007 doi "https://doi.org/10.1073/pnas.97.17.9482" @default.
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