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• W2055871285 abstract "<h3>Hypothesis</h3> C-reactive protein (CRP) is an acute-phase protein produced by the liver. We hypothesize that an early dampened CRP response after major liver resection is of prognostic importance in predicting posthepatectomy liver failure (PHLF). <h3>Design</h3> Serum CRP levels were determined on postoperative days 1, 3, and 7 in patients undergoing liver resection (stratified into minor [≤2 segments], standard [3 or 4 segments], and extended [≥5 segments]). Correlations were made with indices of PHLF (hyperbilirubinemia, coagulopathy, ascites, and encephalopathy), multi-organ dysfunction syndrome, sepsis, and death. <h3>Setting</h3> Division of Hepatobiliary and Transplant Surgery, Leeds Teaching Hospitals National Health Service Trust, England. <h3>Patients</h3> One hundred thirty-eight individuals who underwent liver resection. <h3>Main Outcome Measures</h3> Sepsis, PHLF, and mortality. <h3>Results</h3> A total of 138 liver resections (39 minor, 51 standard, and 48 extended) were included. Median serum CRP levels on day 1 were significantly lower after extended liver resection (28 mg/L; range, 5-119 mg/L [to convert to nanomoles per liter, multiply by 9.524]) compared with standard resection (41 mg/L; range, 5-85 mg/L) and minor resection (51 mg/L; range, 8-203 mg/L; χ² = 19;<i>P</i> < .001). Similar differences were observed on day 3 (χ² = 27;<i>P</i> < .001). Postoperative day 1 CRP levels were significantly lower in patients developing PHLF (hyperbilirubinemia,<i>P</i> = .001; ascites,<i>P</i> < .001; coagulopathy,<i>P</i> = .002; and encephalopathy,<i>P</i> < .001) or multiorgan dysfunction syndrome (<i>P</i> = .009) or who died (<i>P</i> = .01). Day 1 serum CRP levels and extent of resection were independent predictors of PHLF in multivariate analysis. <h3>Conclusion</h3> The early dampened CRP response after major liver resection may reflect poor hepatic reserve that could have prognostic utility." @default.
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• W2055871285 date "2008-03-01" @default.
• W2055871285 modified "2023-10-12" @default.
• W2055871285 title "Prognostic Utility of Postoperative C-reactive Protein for Posthepatectomy Liver Failure" @default.
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• W2055871285 doi "https://doi.org/10.1001/archsurg.2007.75" @default.
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