FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055872359> ?p ?o ?g. }

• W2055872359 endingPage "141" @default.
• W2055872359 startingPage "133" @default.
• W2055872359 abstract "This review will discuss the role of aromatase inhibitors (AIs) in the adjuvant setting, and will summarize major strategies behind individual adjuvant trials using aromatase inhibitors. Studies with the third generation AIs including anastrozole, letrozole and exemestane, have shown better outcome and improved therapeutic ratio over second line hormonal approaches (i.e. progestins or aminoglutethimide) and, more recently, over tamoxifen also. These promising results have led recently to testing of AIs in the adjuvant setting for postmenopausal patients. Most trials now in progress are evaluating the role of new AIs versus tamoxifen (T) given x 5 years, which in most institutions is currently the standard hormonal adjuvant therapy for breast cancer. Three adjuvant approaches are being tested. First is the use of AI+T x 5 years in combination versus each agent alone, as reflected in the recently completed ATAC trial. Second is a sequential approach T first x 2-3 years followed by AIs x 2-3 years, or the other way round; and third, T x 5 years followed by AIs for additional 5 years (i.e. total duration of adjuvant hormones of 10 years). Many patients in the above trials will survive their first cancer. Hence, the non-oncological outcomes known to be affected by hormones are of rising importance. Therefore, the assessment of lipids as surrogates for cardiovascular morbidity, and of bone mineral status, as a marker for osteoporosis/bone fractures, is an important component of these trials. Also discussed in this review are proposals for future studies of AIs with focus on hormone resistance, such as early alteration of multiple hormonal agents or their intermittent use, the impact of the new generation of SERMs or 'pure' antiestrogens on activity of AIs, and the rising importance of AIs interacting with biologicals, cytokines or hormone modulators." @default.
• W2055872359 created "2016-06-24" @default.
• W2055872359 creator A5054500022 @default.
• W2055872359 date "2001-12-01" @default.
• W2055872359 modified "2023-09-24" @default.
• W2055872359 title "Adjuvant trials of aromatase inhibitors: determining the future landscape of adjuvant endocrine therapy" @default.
• W2055872359 cites W1262485082 @default.
• W2055872359 cites W1520764408 @default.
• W2055872359 cites W1538052785 @default.
• W2055872359 cites W1562190372 @default.
• W2055872359 cites W1599710134 @default.
• W2055872359 cites W1932574503 @default.
• W2055872359 cites W1934173384 @default.
• W2055872359 cites W1970863086 @default.
• W2055872359 cites W1983557083 @default.
• W2055872359 cites W1993837674 @default.
• W2055872359 cites W1997883187 @default.
• W2055872359 cites W2003088652 @default.
• W2055872359 cites W2004943038 @default.
• W2055872359 cites W2006091725 @default.
• W2055872359 cites W2009428030 @default.
• W2055872359 cites W2024229186 @default.
• W2055872359 cites W2036934183 @default.
• W2055872359 cites W2039864977 @default.
• W2055872359 cites W2042041418 @default.
• W2055872359 cites W2042714596 @default.
• W2055872359 cites W2043855853 @default.
• W2055872359 cites W2055386238 @default.
• W2055872359 cites W2068385664 @default.
• W2055872359 cites W2069064042 @default.
• W2055872359 cites W2070991617 @default.
• W2055872359 cites W2090992330 @default.
• W2055872359 cites W2100450267 @default.
• W2055872359 cites W2106841768 @default.
• W2055872359 cites W2112629831 @default.
• W2055872359 cites W2125324517 @default.
• W2055872359 cites W2133249365 @default.
• W2055872359 cites W2141647078 @default.
• W2055872359 cites W2156082673 @default.
• W2055872359 cites W2157681187 @default.
• W2055872359 cites W2160433381 @default.
• W2055872359 cites W2161550802 @default.
• W2055872359 cites W2161837912 @default.
• W2055872359 cites W2169878419 @default.
• W2055872359 cites W2172185687 @default.
• W2055872359 cites W2242258808 @default.
• W2055872359 cites W2288573156 @default.
• W2055872359 cites W2332829713 @default.
• W2055872359 cites W2344444710 @default.
• W2055872359 cites W2412684504 @default.
• W2055872359 cites W850470413 @default.
• W2055872359 doi "https://doi.org/10.1016/s0960-0760(01)00159-5" @default.
• W2055872359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11850217" @default.
• W2055872359 hasPublicationYear "2001" @default.
• W2055872359 type Work @default.
• W2055872359 sameAs 2055872359 @default.
• W2055872359 citedByCount "9" @default.
• W2055872359 crossrefType "journal-article" @default.
• W2055872359 hasAuthorship W2055872359A5054500022 @default.
• W2055872359 hasConcept C121608353 @default.
• W2055872359 hasConcept C126322002 @default.
• W2055872359 hasConcept C143998085 @default.
• W2055872359 hasConcept C2775860665 @default.
• W2055872359 hasConcept C2775976807 @default.
• W2055872359 hasConcept C2776166826 @default.
• W2055872359 hasConcept C2776215463 @default.
• W2055872359 hasConcept C2777176818 @default.
• W2055872359 hasConcept C2777863537 @default.
• W2055872359 hasConcept C2777982462 @default.
• W2055872359 hasConcept C2778311097 @default.
• W2055872359 hasConcept C2778504769 @default.
• W2055872359 hasConcept C2778812593 @default.
• W2055872359 hasConcept C29456083 @default.
• W2055872359 hasConcept C530470458 @default.
• W2055872359 hasConcept C535046627 @default.
• W2055872359 hasConcept C71924100 @default.
• W2055872359 hasConceptScore W2055872359C121608353 @default.
• W2055872359 hasConceptScore W2055872359C126322002 @default.
• W2055872359 hasConceptScore W2055872359C143998085 @default.
• W2055872359 hasConceptScore W2055872359C2775860665 @default.
• W2055872359 hasConceptScore W2055872359C2775976807 @default.
• W2055872359 hasConceptScore W2055872359C2776166826 @default.
• W2055872359 hasConceptScore W2055872359C2776215463 @default.
• W2055872359 hasConceptScore W2055872359C2777176818 @default.
• W2055872359 hasConceptScore W2055872359C2777863537 @default.
• W2055872359 hasConceptScore W2055872359C2777982462 @default.
• W2055872359 hasConceptScore W2055872359C2778311097 @default.
• W2055872359 hasConceptScore W2055872359C2778504769 @default.
• W2055872359 hasConceptScore W2055872359C2778812593 @default.
• W2055872359 hasConceptScore W2055872359C29456083 @default.
• W2055872359 hasConceptScore W2055872359C530470458 @default.
• W2055872359 hasConceptScore W2055872359C535046627 @default.
• W2055872359 hasConceptScore W2055872359C71924100 @default.
• W2055872359 hasIssue "1-5" @default.
• W2055872359 hasLocation W20558723591 @default.
• W2055872359 hasLocation W20558723592 @default.
• W2055872359 hasOpenAccess W2055872359 @default.
• W2055872359 hasPrimaryLocation W20558723591 @default.

• next