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• W2055881747 endingPage "376" @default.
• W2055881747 startingPage "366" @default.
• W2055881747 abstract "The transforming growth factor-β (TGF-β) signaling pathway plays important roles in maintaining normal tissue homeostasis, and is tightly controlled by a network of biomolecules. MicroRNAs (miRNAs) are small noncoding RNAs of ∼22 nucleotides that regulate gene expression at posttranscriptional levels. Increasing evidence points to the important role of miRNAs in TGF-β signaling. OncomicroRNA miR-21 has been established as a key regulator of mesenchymal phenotype transition induced by TGF-β. However, the effects of miR-21 on epithelial biology involved in TGF-β signaling pathway such as cytostatic program and epithelial to mesenchymal transition (EMT) processes are unclear. Here we show that miR-21 is upregulated after TGF-β exposure in both growth inhibition and EMT models of HaCaT keratinocytes. To determine the potential roles of miR-21 in TGF-β-induced growth-arrest and EMT models, we showed that ectopic expression of miR-21 overcame TGF-β' growth-inhibitory effect and the knockdown of miR-21 potentialized this effect, but perturbation of miR-21 levels had little effect on EMT. Moreover, TGFBR2, PTEN, PDCD4, and TAp63 were identified as targets of miR-21 in HaCaT cells. And among them, TGFBR2, PTEN, and TAp63 were associated with TGF-β-induced cytostatic program. Thus, our results suggest that miR-21 regulates the ability of epithelial cells to respond to TGF-β, with potential impact on epithelium homeostasis, wound-healing and tumorigenesis." @default.
• W2055881747 created "2016-06-24" @default.
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• W2055881747 date "2012-02-01" @default.
• W2055881747 modified "2023-09-24" @default.
• W2055881747 title "TGF-β-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-β in HaCaT cells" @default.
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• W2055881747 doi "https://doi.org/10.1016/j.biocel.2011.11.012" @default.
• W2055881747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22119803" @default.
• W2055881747 hasPublicationYear "2012" @default.
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