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• W2055883920 abstract "In our efforts to develop safe and active chemical entities from nature, we first identified poliothrysoside (1), a phytoconstituent isolated from Flacourtia indica, possessing antidiabetic potential. Subsequently, fifteen derivatives (2-16) were synthesized to assess the activity profile of this class. All the compounds were analyzed for their glucose uptake potency in chronic insulin-induced insulin resistant 3T3-L1 adipocytes. Interestingly, compound 2 exhibited strong ability to increase the insulin sensitivity, primarily activating the AMPK signaling pathway and also inhibited the adipogenesis in 3T3-L1 adipocytes, in concentration dependent manner. Overall, these studies suggest the potential of poliothrysoside and its derivatives as promising leads for non-insulin dependent type 2 diabetes (T2D)." @default.
• W2055883920 created "2016-06-24" @default.
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• W2055883920 date "2014-10-01" @default.
• W2055883920 modified "2023-10-08" @default.
• W2055883920 title "Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis" @default.
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• W2055883920 doi "https://doi.org/10.1016/j.ejmech.2014.09.015" @default.
• W2055883920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25216379" @default.
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