Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055884720> ?p ?o ?g. }
- W2055884720 endingPage "915" @default.
- W2055884720 startingPage "907" @default.
- W2055884720 abstract "We investigated the effect of stimulation of H1-receptors with histamine on protein tyrosine phosphorylation levels in guinea-pig left atrium and evaluated the influences of tyrosine kinase inhibitors on the positive inotropic effect mediated by H1-receptors in this tissue. Histamine induced an increase in tyrosine phosphorylation in four main clusters of proteins with apparent molecular weights of 25, 35, 65 and 150 kDa. Tyrosine phosphorylation of these proteins attained a peak around 2–3 min following histamine stimulation and then declined to or below basal levels. Histamine-induced protein tyrosine phosphorylation was antagonized by the H1-receptor antagonists mepyramine (1 μM) and chlorpheniramine (1 μM), but not by the H2-receptor antagonist cimetidine (10 μM). The positive inotropic effect of histamine was depressed in a concentration-dependent manner by the tyrosine kinase inhibitors tyrphostin A25 (50 to 100 μM) and genistein (10 to 50 μM) but not by the inactive genistein analogue daidzein (50 μM). The positive inotropic effect of isoprenaline was unchanged by tyrphostin A25 and genistein. At a concentration of 1 μM histamine produced a dual-component positive inotropic response composed of an initial increasing phase and a second and late developing, greater positive inotropic phase. Treatment with tyrphostin A25 (100 μM) and genistein (50 μM), but not daidzein (50 μM), significantly attenuated the two components of the inotropic response, although genistein suppressed the initial component more markedly than the late component. We conclude that increased protein tyrosine phosphorylation may play an important role in initiating at least some part of the positive inotropic effect of H1-receptor stimulation in guinea-pig left atrium. British Journal of Pharmacology (2000) 130, 907–915; doi:10.1038/sj.bjp.0703355" @default.
- W2055884720 created "2016-06-24" @default.
- W2055884720 creator A5021102972 @default.
- W2055884720 creator A5027728106 @default.
- W2055884720 creator A5032793634 @default.
- W2055884720 creator A5038246750 @default.
- W2055884720 creator A5048353164 @default.
- W2055884720 creator A5059316181 @default.
- W2055884720 date "2000-06-01" @default.
- W2055884720 modified "2023-09-25" @default.
- W2055884720 title "Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H<sub>1</sub>-receptors with histamine in guinea-pig left atrium" @default.
- W2055884720 cites W1479814947 @default.
- W2055884720 cites W1528696665 @default.
- W2055884720 cites W1656644300 @default.
- W2055884720 cites W1775749144 @default.
- W2055884720 cites W1906504131 @default.
- W2055884720 cites W1966112698 @default.
- W2055884720 cites W1970953757 @default.
- W2055884720 cites W1972856897 @default.
- W2055884720 cites W1975642651 @default.
- W2055884720 cites W1981353188 @default.
- W2055884720 cites W1985293781 @default.
- W2055884720 cites W1986549537 @default.
- W2055884720 cites W2016999722 @default.
- W2055884720 cites W2019097221 @default.
- W2055884720 cites W2028227665 @default.
- W2055884720 cites W2029912714 @default.
- W2055884720 cites W2032209787 @default.
- W2055884720 cites W2040641738 @default.
- W2055884720 cites W2041514128 @default.
- W2055884720 cites W2041679683 @default.
- W2055884720 cites W2045986542 @default.
- W2055884720 cites W2052058015 @default.
- W2055884720 cites W2052751369 @default.
- W2055884720 cites W2057007875 @default.
- W2055884720 cites W2057304101 @default.
- W2055884720 cites W2065677697 @default.
- W2055884720 cites W2066990421 @default.
- W2055884720 cites W2073744428 @default.
- W2055884720 cites W2074217926 @default.
- W2055884720 cites W2080857924 @default.
- W2055884720 cites W2086021309 @default.
- W2055884720 cites W2086041680 @default.
- W2055884720 cites W2108116014 @default.
- W2055884720 cites W2127866797 @default.
- W2055884720 cites W2175146729 @default.
- W2055884720 cites W2240387425 @default.
- W2055884720 cites W2260545327 @default.
- W2055884720 cites W2267676114 @default.
- W2055884720 cites W2303499764 @default.
- W2055884720 cites W2411476698 @default.
- W2055884720 cites W3102875255 @default.
- W2055884720 cites W36652335 @default.
- W2055884720 cites W79302672 @default.
- W2055884720 doi "https://doi.org/10.1038/sj.bjp.0703355" @default.
- W2055884720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572121" @default.
- W2055884720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10864899" @default.
- W2055884720 hasPublicationYear "2000" @default.
- W2055884720 type Work @default.
- W2055884720 sameAs 2055884720 @default.
- W2055884720 citedByCount "7" @default.
- W2055884720 countsByYear W20558847202017 @default.
- W2055884720 countsByYear W20558847202021 @default.
- W2055884720 countsByYear W20558847202023 @default.
- W2055884720 crossrefType "journal-article" @default.
- W2055884720 hasAuthorship W2055884720A5021102972 @default.
- W2055884720 hasAuthorship W2055884720A5027728106 @default.
- W2055884720 hasAuthorship W2055884720A5032793634 @default.
- W2055884720 hasAuthorship W2055884720A5038246750 @default.
- W2055884720 hasAuthorship W2055884720A5048353164 @default.
- W2055884720 hasAuthorship W2055884720A5059316181 @default.
- W2055884720 hasBestOaLocation W20558847202 @default.
- W2055884720 hasConcept C10335311 @default.
- W2055884720 hasConcept C1122143 @default.
- W2055884720 hasConcept C11960822 @default.
- W2055884720 hasConcept C126322002 @default.
- W2055884720 hasConcept C134018914 @default.
- W2055884720 hasConcept C159545944 @default.
- W2055884720 hasConcept C170493617 @default.
- W2055884720 hasConcept C185592680 @default.
- W2055884720 hasConcept C2776165026 @default.
- W2055884720 hasConcept C2776885963 @default.
- W2055884720 hasConcept C2777553839 @default.
- W2055884720 hasConcept C2778298627 @default.
- W2055884720 hasConcept C2780955279 @default.
- W2055884720 hasConcept C34400551 @default.
- W2055884720 hasConcept C42362537 @default.
- W2055884720 hasConcept C55493867 @default.
- W2055884720 hasConcept C71924100 @default.
- W2055884720 hasConcept C86803240 @default.
- W2055884720 hasConceptScore W2055884720C10335311 @default.
- W2055884720 hasConceptScore W2055884720C1122143 @default.
- W2055884720 hasConceptScore W2055884720C11960822 @default.
- W2055884720 hasConceptScore W2055884720C126322002 @default.
- W2055884720 hasConceptScore W2055884720C134018914 @default.
- W2055884720 hasConceptScore W2055884720C159545944 @default.
- W2055884720 hasConceptScore W2055884720C170493617 @default.
- W2055884720 hasConceptScore W2055884720C185592680 @default.