FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055884993> ?p ?o ?g. }

• W2055884993 endingPage "887" @default.
• W2055884993 startingPage "875" @default.
• W2055884993 abstract "Preoperative chemoradiotherapy for advanced rectal cancer has been an important therapeutic tool to improve the long-term results of curative resection. It is not known whether preoperative chemoradiotherapy for advanced rectal cancer influences the perioperative course of immune parameters.Thirty patients with rectal cancer underwent surgery with (study group, n = 15) or without (control group, n = 15) preoperative chemoradiotherapy (2 cycles of 5-fluorouracil, 45 Gy). Blood samples were taken before neoadjuvant therapy, preoperatively, and on Days 1, 2, and 5 after surgery. Cell numbers of lymphocyte subpopulations, granulocytes, monocytes, and natural killer cells were determined by flow cytometry; tumor necrosis factor-alpha and interleukin-6 serum levels were measured with enzyme-linked immunosorbent assay.Significant differences between study and control patients (P < 0.05) were detected regarding circulating interleukin-6 and tumor necrosis factor-alpha levels, with depression of the proinflammatory response to surgery in study patients. Similarly, granulocytosis and monocytosis after surgery were significantly lower in patients after neoadjuvant therapy. Furthermore, cell counts of total T lymphocytes, T helper cells, B lymphocytes, and natural killer cells were significantly reduced after preoperative chemoradiotherapy. This depression of cell-mediated immunity in study patients was even more pronounced after surgery.Preoperative chemoradiotherapy for advanced rectal cancer results in a significant preoperative and postoperative immune dysfunction as indicated by depression of lymphocyte subpopulations, monocytes, granulocytes, and proinflammatory cytokine release. These findings are of importance because increased perioperative morbidity and mortality rates have been observed after preoperative chemoradiotherapy." @default.
• W2055884993 created "2016-06-24" @default.
• W2055884993 creator A5016096702 @default.
• W2055884993 creator A5022512059 @default.
• W2055884993 creator A5029634137 @default.
• W2055884993 creator A5052942960 @default.
• W2055884993 creator A5063067568 @default.
• W2055884993 creator A5068817915 @default.
• W2055884993 creator A5079475850 @default.
• W2055884993 creator A5086036635 @default.
• W2055884993 creator A5077228763 @default.
• W2055884993 date "2003-07-01" @default.
• W2055884993 modified "2023-09-23" @default.
• W2055884993 title "Detrimental Immunologic Effects of Preoperative Chemoradiotherapy in Advanced Rectal Cancer" @default.
• W2055884993 cites W1536690700 @default.
• W2055884993 cites W1709006658 @default.
• W2055884993 cites W1896630734 @default.
• W2055884993 cites W1969561516 @default.
• W2055884993 cites W1972793829 @default.
• W2055884993 cites W1975570770 @default.
• W2055884993 cites W1979964065 @default.
• W2055884993 cites W1987263428 @default.
• W2055884993 cites W1987475727 @default.
• W2055884993 cites W1994635546 @default.
• W2055884993 cites W2002014324 @default.
• W2055884993 cites W2003451525 @default.
• W2055884993 cites W2003706429 @default.
• W2055884993 cites W2011263395 @default.
• W2055884993 cites W2014425177 @default.
• W2055884993 cites W2018120089 @default.
• W2055884993 cites W2021416608 @default.
• W2055884993 cites W2027160253 @default.
• W2055884993 cites W2039160404 @default.
• W2055884993 cites W2039721232 @default.
• W2055884993 cites W2041542133 @default.
• W2055884993 cites W2042770433 @default.
• W2055884993 cites W2043236131 @default.
• W2055884993 cites W2045305629 @default.
• W2055884993 cites W2067663745 @default.
• W2055884993 cites W2070009890 @default.
• W2055884993 cites W2070659456 @default.
• W2055884993 cites W2080180920 @default.
• W2055884993 cites W2086858064 @default.
• W2055884993 cites W2089714928 @default.
• W2055884993 cites W2091884388 @default.
• W2055884993 cites W2118989510 @default.
• W2055884993 cites W2169680934 @default.
• W2055884993 cites W2317184793 @default.
• W2055884993 cites W2334576825 @default.
• W2055884993 cites W2404137834 @default.
• W2055884993 cites W2408391487 @default.
• W2055884993 cites W2408970728 @default.
• W2055884993 cites W2415346160 @default.
• W2055884993 cites W2415845056 @default.
• W2055884993 cites W2469971171 @default.
• W2055884993 cites W2750149595 @default.
• W2055884993 cites W96506922 @default.
• W2055884993 cites W2740191585 @default.
• W2055884993 doi "https://doi.org/10.1007/s10350-004-6677-z" @default.
• W2055884993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12847360" @default.
• W2055884993 hasPublicationYear "2003" @default.
• W2055884993 type Work @default.
• W2055884993 sameAs 2055884993 @default.
• W2055884993 citedByCount "40" @default.
• W2055884993 countsByYear W20558849932012 @default.
• W2055884993 countsByYear W20558849932013 @default.
• W2055884993 countsByYear W20558849932014 @default.
• W2055884993 countsByYear W20558849932015 @default.
• W2055884993 countsByYear W20558849932016 @default.
• W2055884993 countsByYear W20558849932017 @default.
• W2055884993 countsByYear W20558849932020 @default.
• W2055884993 countsByYear W20558849932022 @default.
• W2055884993 crossrefType "journal-article" @default.
• W2055884993 hasAuthorship W2055884993A5016096702 @default.
• W2055884993 hasAuthorship W2055884993A5022512059 @default.
• W2055884993 hasAuthorship W2055884993A5029634137 @default.
• W2055884993 hasAuthorship W2055884993A5052942960 @default.
• W2055884993 hasAuthorship W2055884993A5063067568 @default.
• W2055884993 hasAuthorship W2055884993A5068817915 @default.
• W2055884993 hasAuthorship W2055884993A5077228763 @default.
• W2055884993 hasAuthorship W2055884993A5079475850 @default.
• W2055884993 hasAuthorship W2055884993A5086036635 @default.
• W2055884993 hasConcept C121608353 @default.
• W2055884993 hasConcept C126322002 @default.
• W2055884993 hasConcept C141071460 @default.
• W2055884993 hasConcept C143998085 @default.
• W2055884993 hasConcept C164027704 @default.
• W2055884993 hasConcept C203014093 @default.
• W2055884993 hasConcept C2776098842 @default.
• W2055884993 hasConcept C2776914184 @default.
• W2055884993 hasConcept C2778424827 @default.
• W2055884993 hasConcept C31174226 @default.
• W2055884993 hasConcept C526805850 @default.
• W2055884993 hasConcept C71924100 @default.
• W2055884993 hasConcept C8891405 @default.
• W2055884993 hasConcept C90924648 @default.
• W2055884993 hasConceptScore W2055884993C121608353 @default.
• W2055884993 hasConceptScore W2055884993C126322002 @default.

• next