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- W2055897718 abstract "The membrane attack complex and perforin (MACPF) superfamily is one of the largest families of pore-forming molecules. Although MACPF proteins are able to destruct invading microbes, several MACPF proteins play roles in embryonic development, neural migration or tumor suppression. We describe two apextrin-like proteins (ApelB and ApelP) and one MACPF-domain-containing protein (Macp) in Mytilus galloprovincialis. The two apextrin-like proteins did not present any conserved domain. The Macp protein contained the membrane/attack complex domain and its signature motif. Gene expression during larval development was analyzed by RT-PCR. There was a stage-specific up-regulation of the three proteins, suggesting that they play a role in development. Apextrin-like proteins were highly expressed at blastula and trochophore stage, whereas Macp was expressed at veliger stage. RT-PCR revealed up-regulation of the three genes in tissues and hemocytes from adults treated with bacteria and pathogen-associated molecular patterns, suggesting that they may be involved in the immune response." @default.
- W2055897718 created "2016-06-24" @default.
- W2055897718 creator A5006562505 @default.
- W2055897718 creator A5035725666 @default.
- W2055897718 creator A5061485833 @default.
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- W2055897718 date "2011-10-01" @default.
- W2055897718 modified "2023-10-18" @default.
- W2055897718 title "Involvement of pore-forming molecules in immune defense and development of the Mediterranean mussel (Mytilus galloprovincialis)" @default.
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- W2055897718 doi "https://doi.org/10.1016/j.dci.2011.03.023" @default.
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