FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055901084> ?p ?o ?g. }

• W2055901084 endingPage "273" @default.
• W2055901084 startingPage "263" @default.
• W2055901084 abstract "Abstract: Previous studies established that oral glutamine (GLN) reduced tumor development in implantable and 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer models. This finding was associated with a decrease in tumor glutathione (GSH) levels, while maintaining normal gut, blood, and breast GSH. Alterations in GSH levels contribute to the control of apoptotic and cell cycle-regulating signaling. The aim of this study was to examine the role of dietary GLN on activation of p53 and c-myc, which play critical roles in cancer development and sensitivity to radiation and chemotherapy. Mammary gland carcinomas were induced in rats by DMBA. The rats were gavaged daily with GLN or water (controls), starting 1 wk prior DMBA-application and throughout the duration of the experiment (11 wk after DMBA). Tumor DNA was examined for mutations in p53 exons 5 and 6. Protein and mRNA levels of p53, p21WAF1/CIP1, PTEN, IGF-IR, mdm2, and c-myc in tumors of GLN-supplemented rats were compared with those of the control rats (received water). The sequencing of p53 showed that it was wild type. Increased phosphorylation of p53, as well as higher mRNA and protein levels of p21WAF1/CIP1, PTEN, and mdm2, and lower levels of IGF-IR were detected in tumors of GLN-supplemented rats vs. controls. Both phosphorylated c-myc and c-myc mRNA levels were reduced by GLN. The up-regulation of tumor p53 signaling and down-regulation of c-myc, in addition to previously established inhibition of Akt signaling in DMBA-breast cancer model, suggest that dietary GLN could be a useful approach for increasing the effectiveness of cancer treatment." @default.
• W2055901084 created "2016-06-24" @default.
• W2055901084 creator A5006551198 @default.
• W2055901084 creator A5033807692 @default.
• W2055901084 creator A5051483672 @default.
• W2055901084 creator A5074105390 @default.
• W2055901084 date "2006-07-01" @default.
• W2055901084 modified "2023-09-27" @default.
• W2055901084 title "Modulation of p53 and c-myc in DMBA-Induced Mammary Tumors by Oral Glutamine" @default.
• W2055901084 cites W1581565952 @default.
• W2055901084 cites W1964699291 @default.
• W2055901084 cites W1967870287 @default.
• W2055901084 cites W1972358035 @default.
• W2055901084 cites W1973808108 @default.
• W2055901084 cites W1976229832 @default.
• W2055901084 cites W1979319210 @default.
• W2055901084 cites W1994318934 @default.
• W2055901084 cites W2004942497 @default.
• W2055901084 cites W2011900402 @default.
• W2055901084 cites W2015519364 @default.
• W2055901084 cites W2015754119 @default.
• W2055901084 cites W2016105349 @default.
• W2055901084 cites W2022183036 @default.
• W2055901084 cites W2023139493 @default.
• W2055901084 cites W2023429030 @default.
• W2055901084 cites W2025106434 @default.
• W2055901084 cites W2033667332 @default.
• W2055901084 cites W2038173255 @default.
• W2055901084 cites W2045753882 @default.
• W2055901084 cites W2049592113 @default.
• W2055901084 cites W2050981751 @default.
• W2055901084 cites W2055712486 @default.
• W2055901084 cites W2056530510 @default.
• W2055901084 cites W2060730896 @default.
• W2055901084 cites W2067751798 @default.
• W2055901084 cites W2069023233 @default.
• W2055901084 cites W2069845811 @default.
• W2055901084 cites W2073709571 @default.
• W2055901084 cites W2074359673 @default.
• W2055901084 cites W2080328815 @default.
• W2055901084 cites W2081894694 @default.
• W2055901084 cites W2082652159 @default.
• W2055901084 cites W2082979850 @default.
• W2055901084 cites W2083227753 @default.
• W2055901084 cites W2083788758 @default.
• W2055901084 cites W2085974978 @default.
• W2055901084 cites W2094921432 @default.
• W2055901084 cites W2100448419 @default.
• W2055901084 cites W2100550784 @default.
• W2055901084 cites W2110098001 @default.
• W2055901084 cites W2122387572 @default.
• W2055901084 cites W2128822546 @default.
• W2055901084 cites W2129539814 @default.
• W2055901084 cites W2131488598 @default.
• W2055901084 cites W2145349694 @default.
• W2055901084 cites W2146421519 @default.
• W2055901084 cites W2147330111 @default.
• W2055901084 cites W2166858659 @default.
• W2055901084 cites W2167527436 @default.
• W2055901084 cites W2366535405 @default.
• W2055901084 cites W2404289942 @default.
• W2055901084 cites W295447163 @default.
• W2055901084 cites W4232935338 @default.
• W2055901084 cites W4248447919 @default.
• W2055901084 doi "https://doi.org/10.1207/s15327914nc5402_13" @default.
• W2055901084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16898871" @default.
• W2055901084 hasPublicationYear "2006" @default.
• W2055901084 type Work @default.
• W2055901084 sameAs 2055901084 @default.
• W2055901084 citedByCount "17" @default.
• W2055901084 countsByYear W20559010842013 @default.
• W2055901084 countsByYear W20559010842015 @default.
• W2055901084 countsByYear W20559010842016 @default.
• W2055901084 countsByYear W20559010842017 @default.
• W2055901084 countsByYear W20559010842021 @default.
• W2055901084 countsByYear W20559010842022 @default.
• W2055901084 crossrefType "journal-article" @default.
• W2055901084 hasAuthorship W2055901084A5006551198 @default.
• W2055901084 hasAuthorship W2055901084A5033807692 @default.
• W2055901084 hasAuthorship W2055901084A5051483672 @default.
• W2055901084 hasAuthorship W2055901084A5074105390 @default.
• W2055901084 hasConcept C11960822 @default.
• W2055901084 hasConcept C121608353 @default.
• W2055901084 hasConcept C126322002 @default.
• W2055901084 hasConcept C134018914 @default.
• W2055901084 hasConcept C190283241 @default.
• W2055901084 hasConcept C2776187077 @default.
• W2055901084 hasConcept C2776192174 @default.
• W2055901084 hasConcept C2777609662 @default.
• W2055901084 hasConcept C2778938436 @default.
• W2055901084 hasConcept C2779256057 @default.
• W2055901084 hasConcept C2779349466 @default.
• W2055901084 hasConcept C502942594 @default.
• W2055901084 hasConcept C515207424 @default.
• W2055901084 hasConcept C530470458 @default.
• W2055901084 hasConcept C55493867 @default.
• W2055901084 hasConcept C555283112 @default.
• W2055901084 hasConcept C71924100 @default.

• next