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• W2055910086 abstract "A direct radioligand binding technique utilizing a β-adrenergic antagonist [3H]Dihydroalprenolol ([3H]DHA) was employed in the identification and characterization of fetal palatal β-adrenergic receptors. [3H]DHA binding was saturable (Bmax 16 fmol/mg protein) with high affinity and an apparent equilibrium dissociation constant (KD) of 1.5 nM. Binding of [3H]DHA was displaced by the competitive β-adrenergic antagonist propranolol in a concentration-dependent manner. Dissociation kinetic studies demonstrated almost complete reversibility of radioligand binding within 60 min. The functionality of these β-adrenergic receptors was demonstrated by showing that fetal palatal mesenchymal cells responded to catecholamine agonists with dose-dependent accumulations of intracellular cAMP. This effect could be entirely blocked by the β-antagonist, propranolol. The relative potency order of catecholamines in eliciting an elevation of cellular cAMP was characteristic of a β2-adrenergic receptor-mediated response: (−) isoproterenol > (−) epinephrine > (−) norepinephrine. In addition, this response was found to be stereospecific with (−) isoproterenol being significantly more potent than (+) isoproterenol. Both the [3H]DHA binding characteristics and the catecholamine sensitivity of fetal palatal tissue support the presence of adenylate cyclase-coupled β-adrenergic receptors in the developing mammalian secondary palate." @default.
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• W2055910086 date "1984-02-01" @default.
• W2055910086 modified "2023-09-27" @default.
• W2055910086 title "Identification of adenylate cyclase-coupled β-adrenergic receptors in the developing mammalian palate" @default.
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• W2055910086 doi "https://doi.org/10.1016/0006-291x(84)91638-3" @default.
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