FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055914441> ?p ?o ?g. }

• W2055914441 endingPage "630" @default.
• W2055914441 startingPage "624" @default.
• W2055914441 abstract "Vascular endothelial growth factor (VEGF) is a key mediator of physiological and pathological angiogenesis. All solid tumors are dependent on pathological angiogenesis, and anti-VEGF therapy has demonstrated clinical benefit in breast, colorectal, non-small-cell lung, and renal carcinomas. Central nervous system metastases are common in many of these tumor types. An increased risk of bleeding has been reported with anti-VEGF therapy, but the risk of intracranial bleeding is unknown with this type of therapy. We reviewed the available data to investigate the risk of intracranial bleeding with anti-VEGF therapy in the presence and absence of CNS metastases. The PubMed and Medline databases and the Proceedings of the American Society of Clinical Oncology (ASCO) annual meetings were searched for articles, abstracts, and presentations of clinical trials. We identified 57 trials examining the safety and efficacy of anti-VEGF therapy in a total of 10,598 patients. Four trials examined the use of anti-VEGF therapy in treating patients with brain metastases. The presence of CNS metastases was a stated exclusion criterion in 76% of trials. The rate of intracranial bleeding was negligible. We conclude that there is no trial evidence that anti-VEGF therapy confers an increased risk of intracranial bleeding, even in the presence of CNS metastases. Future trials of anti-VEGF therapy should not exclude patients with controlled CNS metastases at enrollment." @default.
• W2055914441 created "2016-06-24" @default.
• W2055914441 creator A5010759705 @default.
• W2055914441 creator A5058371726 @default.
• W2055914441 creator A5076054848 @default.
• W2055914441 date "2008-08-01" @default.
• W2055914441 modified "2023-09-23" @default.
• W2055914441 title "What is the risk of intracranial bleeding during anti-VEGF therapy?" @default.
• W2055914441 cites W1600521177 @default.
• W2055914441 cites W1977253304 @default.
• W2055914441 cites W1993016627 @default.
• W2055914441 cites W1999966467 @default.
• W2055914441 cites W2000292756 @default.
• W2055914441 cites W2012852444 @default.
• W2055914441 cites W2018348203 @default.
• W2055914441 cites W2018992636 @default.
• W2055914441 cites W2034048944 @default.
• W2055914441 cites W2041098552 @default.
• W2055914441 cites W2046507292 @default.
• W2055914441 cites W2051107088 @default.
• W2055914441 cites W2056802932 @default.
• W2055914441 cites W2062316437 @default.
• W2055914441 cites W2074542185 @default.
• W2055914441 cites W2078782778 @default.
• W2055914441 cites W2091872802 @default.
• W2055914441 cites W2093783077 @default.
• W2055914441 cites W2096514095 @default.
• W2055914441 cites W2098737602 @default.
• W2055914441 cites W2100785570 @default.
• W2055914441 cites W2104300061 @default.
• W2055914441 cites W2105984177 @default.
• W2055914441 cites W2108938302 @default.
• W2055914441 cites W2111060860 @default.
• W2055914441 cites W2112759697 @default.
• W2055914441 cites W2113788015 @default.
• W2055914441 cites W2114159573 @default.
• W2055914441 cites W2116177733 @default.
• W2055914441 cites W2125447919 @default.
• W2055914441 cites W2136011574 @default.
• W2055914441 cites W2139511378 @default.
• W2055914441 cites W2145224595 @default.
• W2055914441 cites W2145835533 @default.
• W2055914441 cites W2147178092 @default.
• W2055914441 cites W2149456801 @default.
• W2055914441 cites W2156408558 @default.
• W2055914441 cites W2156575195 @default.
• W2055914441 cites W2156871508 @default.
• W2055914441 cites W2157769714 @default.
• W2055914441 cites W2163124389 @default.
• W2055914441 cites W2168161641 @default.
• W2055914441 cites W2209699441 @default.
• W2055914441 cites W2245655230 @default.
• W2055914441 cites W2258874524 @default.
• W2055914441 cites W2332800771 @default.
• W2055914441 cites W2537283502 @default.
• W2055914441 cites W3009649006 @default.
• W2055914441 cites W4232427147 @default.
• W2055914441 cites W4240228356 @default.
• W2055914441 cites W4242397642 @default.
• W2055914441 doi "https://doi.org/10.1215/15228517-2008-010" @default.
• W2055914441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2666237" @default.
• W2055914441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18539884" @default.
• W2055914441 hasPublicationYear "2008" @default.
• W2055914441 type Work @default.
• W2055914441 sameAs 2055914441 @default.
• W2055914441 citedByCount "69" @default.
• W2055914441 countsByYear W20559144412012 @default.
• W2055914441 countsByYear W20559144412013 @default.
• W2055914441 countsByYear W20559144412014 @default.
• W2055914441 countsByYear W20559144412015 @default.
• W2055914441 countsByYear W20559144412016 @default.
• W2055914441 countsByYear W20559144412017 @default.
• W2055914441 countsByYear W20559144412018 @default.
• W2055914441 countsByYear W20559144412019 @default.
• W2055914441 countsByYear W20559144412020 @default.
• W2055914441 countsByYear W20559144412021 @default.
• W2055914441 crossrefType "journal-article" @default.
• W2055914441 hasAuthorship W2055914441A5010759705 @default.
• W2055914441 hasAuthorship W2055914441A5058371726 @default.
• W2055914441 hasAuthorship W2055914441A5076054848 @default.
• W2055914441 hasBestOaLocation W20559144411 @default.
• W2055914441 hasConcept C126322002 @default.
• W2055914441 hasConcept C143998085 @default.
• W2055914441 hasConcept C167734588 @default.
• W2055914441 hasConcept C207886595 @default.
• W2055914441 hasConcept C2776694085 @default.
• W2055914441 hasConcept C2777025900 @default.
• W2055914441 hasConcept C2777802072 @default.
• W2055914441 hasConcept C2780394083 @default.
• W2055914441 hasConcept C535046627 @default.
• W2055914441 hasConcept C71924100 @default.
• W2055914441 hasConceptScore W2055914441C126322002 @default.
• W2055914441 hasConceptScore W2055914441C143998085 @default.
• W2055914441 hasConceptScore W2055914441C167734588 @default.
• W2055914441 hasConceptScore W2055914441C207886595 @default.
• W2055914441 hasConceptScore W2055914441C2776694085 @default.
• W2055914441 hasConceptScore W2055914441C2777025900 @default.
• W2055914441 hasConceptScore W2055914441C2777802072 @default.

• next