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- W2055917512 abstract "The direct scalability of microwave-assisted organic synthesis (MAOS) in a prototype laboratory-scale multimode microwave batch reactor is investigated. Several different organic reactions have been scaled-up typically from 1 mmol to 100 mmol scale. The transformations include multicomponent chemistries (Biginelli dihydropyrimidine and Kindler thioamide synthesis), transition metal-catalyzed carbon−carbon cross-coupling protocols (Heck and Negishi reactions), solid-phase organic synthesis, and Diels−Alder cycloaddition reactions using gaseous reagents in prepressurized reaction vessels. A range of different solvents (high and low microwave absorbing), Pd catalysts (homogeneous and heterogeneous), and varying reaction times and temperatures have been explored in these investigations. In all cases, it was possible to achieve similar isolated product yields on going from a small scale (ca. 5 mL processing volume) to a larger scale (max 500 mL volume) without changing the previously optimized reaction conditi..." @default.
- W2055917512 created "2016-06-24" @default.
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- W2055917512 date "2003-08-09" @default.
- W2055917512 modified "2023-10-11" @default.
- W2055917512 title "Scalability of Microwave-Assisted Organic Synthesis. From Single-Mode to Multimode Parallel Batch Reactors" @default.
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- W2055917512 doi "https://doi.org/10.1021/op034075+" @default.
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