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- W2055920121 abstract "Beta-boswellic acids are interesting triterpenoic acids that show different biological activities. Their cytotoxic potential, as well as that of their derivates remained unexploited so far. In this study we were able to prepare derivatives of 11-keto-β-boswellic acid that showed lower IC50 values as determined by a sulphorhodamine B (SRB) assay using several different human tumour cell lines. Thus, the introduction of an amino group at position C-2 led to a significantly improved cytotoxic activity of amine 18. An apoptotic effect of compound 18 was determined using DNA laddering and trypan blue staining experiments." @default.
- W2055920121 created "2016-06-24" @default.
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- W2055920121 date "2015-03-01" @default.
- W2055920121 modified "2023-10-17" @default.
- W2055920121 title "Synthesis and antitumor activity of ring A modified 11-keto-β-boswellic acid derivatives" @default.
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- W2055920121 doi "https://doi.org/10.1016/j.ejmech.2015.01.039" @default.
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