FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055924792> ?p ?o ?g. }

• W2055924792 endingPage "e112640" @default.
• W2055924792 startingPage "e112640" @default.
• W2055924792 abstract "Studies of pharmacogenomics-related traits are increasingly being performed to identify loci that affect either drug response or susceptibility to adverse drug reactions. However, the effect of the polymorphisms can differ in magnitude or be absent depending on the population being assessed. We used the Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus array to characterize the distribution of polymorphisms of pharmacogenetics and pharmacogenomics (PGx) relevance in two samples from the most populous Latin American countries, Brazil and Mexico. The sample from Brazil included 268 individuals from the southeastern state of Rio de Janeiro, and was stratified into census categories. The sample from Mexico comprised 45 Native American Zapotecas and 224 self-identified Mestizo individuals from 5 states located in geographically distant regions in Mexico. We evaluated the admixture proportions in the Brazilian and Mexican samples using a panel of Ancestry Informative Markers extracted from the DMET array, which was validated with genome-wide data. A substantial variation in ancestral proportions across census categories in Brazil, and geographic regions in Mexico was identified. We evaluated the extent of genetic differentiation (measured as FST values) of the genetic markers of the DMET Plus array between the relevant parental populations. Although the average levels of genetic differentiation are low, there is a long tail of markers showing large frequency differences, including markers located in genes belonging to the Cytochrome P450, Solute Carrier (SLC) and UDP-glucuronyltransferase (UGT) families as well as other genes of PGx relevance such as ABCC8, ADH1A, CHST3, PON1, PPARD, PPARG, and VKORC1. We show how differences in admixture history may have an important impact in the distribution of allele and genotype frequencies at the population level." @default.
• W2055924792 created "2016-06-24" @default.
• W2055924792 creator A5001003199 @default.
• W2055924792 creator A5004575782 @default.
• W2055924792 creator A5011034688 @default.
• W2055924792 creator A5012552798 @default.
• W2055924792 creator A5012616417 @default.
• W2055924792 creator A5014721204 @default.
• W2055924792 creator A5035176030 @default.
• W2055924792 creator A5039318228 @default.
• W2055924792 creator A5043368424 @default.
• W2055924792 creator A5061025170 @default.
• W2055924792 creator A5068253209 @default.
• W2055924792 creator A5074411363 @default.
• W2055924792 creator A5077719323 @default.
• W2055924792 creator A5083692113 @default.
• W2055924792 date "2014-11-24" @default.
• W2055924792 modified "2023-10-16" @default.
• W2055924792 title "Exploring the Distribution of Genetic Markers of Pharmacogenomics Relevance in Brazilian and Mexican Populations" @default.
• W2055924792 cites W1515782956 @default.
• W2055924792 cites W1521042820 @default.
• W2055924792 cites W1905856654 @default.
• W2055924792 cites W1972009144 @default.
• W2055924792 cites W1984360602 @default.
• W2055924792 cites W1996072823 @default.
• W2055924792 cites W2006914590 @default.
• W2055924792 cites W2009610362 @default.
• W2055924792 cites W2012747935 @default.
• W2055924792 cites W2016716898 @default.
• W2055924792 cites W2021114575 @default.
• W2055924792 cites W2022905671 @default.
• W2055924792 cites W2026323344 @default.
• W2055924792 cites W2031082289 @default.
• W2055924792 cites W2040953621 @default.
• W2055924792 cites W2043674997 @default.
• W2055924792 cites W2049259235 @default.
• W2055924792 cites W2056809158 @default.
• W2055924792 cites W2060891246 @default.
• W2055924792 cites W2079685822 @default.
• W2055924792 cites W2082854754 @default.
• W2055924792 cites W2083878136 @default.
• W2055924792 cites W2087437533 @default.
• W2055924792 cites W2093298914 @default.
• W2055924792 cites W2096014252 @default.
• W2055924792 cites W2097103181 @default.
• W2055924792 cites W2098126593 @default.
• W2055924792 cites W2100751001 @default.
• W2055924792 cites W2102714321 @default.
• W2055924792 cites W2107916366 @default.
• W2055924792 cites W2108169091 @default.
• W2055924792 cites W2110755408 @default.
• W2055924792 cites W2116181319 @default.
• W2055924792 cites W2123041099 @default.
• W2055924792 cites W2126321110 @default.
• W2055924792 cites W2141388711 @default.
• W2055924792 cites W2158489424 @default.
• W2055924792 cites W2158520652 @default.
• W2055924792 cites W2159379246 @default.
• W2055924792 cites W2161633633 @default.
• W2055924792 cites W2168141575 @default.
• W2055924792 cites W2556823 @default.
• W2055924792 cites W3175417087 @default.
• W2055924792 doi "https://doi.org/10.1371/journal.pone.0112640" @default.
• W2055924792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4242606" @default.
• W2055924792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25419701" @default.
• W2055924792 hasPublicationYear "2014" @default.
• W2055924792 type Work @default.
• W2055924792 sameAs 2055924792 @default.
• W2055924792 citedByCount "56" @default.
• W2055924792 countsByYear W20559247922015 @default.
• W2055924792 countsByYear W20559247922016 @default.
• W2055924792 countsByYear W20559247922017 @default.
• W2055924792 countsByYear W20559247922018 @default.
• W2055924792 countsByYear W20559247922019 @default.
• W2055924792 countsByYear W20559247922020 @default.
• W2055924792 countsByYear W20559247922021 @default.
• W2055924792 countsByYear W20559247922022 @default.
• W2055924792 countsByYear W20559247922023 @default.
• W2055924792 crossrefType "journal-article" @default.
• W2055924792 hasAuthorship W2055924792A5001003199 @default.
• W2055924792 hasAuthorship W2055924792A5004575782 @default.
• W2055924792 hasAuthorship W2055924792A5011034688 @default.
• W2055924792 hasAuthorship W2055924792A5012552798 @default.
• W2055924792 hasAuthorship W2055924792A5012616417 @default.
• W2055924792 hasAuthorship W2055924792A5014721204 @default.
• W2055924792 hasAuthorship W2055924792A5035176030 @default.
• W2055924792 hasAuthorship W2055924792A5039318228 @default.
• W2055924792 hasAuthorship W2055924792A5043368424 @default.
• W2055924792 hasAuthorship W2055924792A5061025170 @default.
• W2055924792 hasAuthorship W2055924792A5068253209 @default.
• W2055924792 hasAuthorship W2055924792A5074411363 @default.
• W2055924792 hasAuthorship W2055924792A5077719323 @default.
• W2055924792 hasAuthorship W2055924792A5083692113 @default.
• W2055924792 hasBestOaLocation W20559247921 @default.
• W2055924792 hasConcept C104317684 @default.
• W2055924792 hasConcept C135763542 @default.
• W2055924792 hasConcept C137132547 @default.
• W2055924792 hasConcept C170734499 @default.

• next