FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055937035> ?p ?o ?g. }

• W2055937035 endingPage "222" @default.
• W2055937035 startingPage "214" @default.
• W2055937035 abstract "<i>Background: </i>The migration of dendritic cells (DCs) from the lungs to the regional lymph nodes is necessary for the development of allergic airway disease. Following activation, mast cells release a variety of stored or de novo-produced inflammatory mediators, several of them being capable of activating DCs. In this study, the role of mast cells on DC migration from the lungs to the thoracic lymph nodes was investigated in sensitized mice. <i>Methods:</i> Mast cell-deficient mice (Kit^W-sh/W-sh) and their wild-type counterparts were sensitized intraperitoneally with ovalbumine (OVA) in saline and challenged by a single intranasal administration of OVA labeled with a fluorescent dye (OVA-Alexa). <i>Results:</i> Following challenge, the relative and absolute amount of OVA- Alexa-positive DCs was clearly increased in sensitized wild-type mice compared to nonsensitized mice. In contrast, sensitized Kit^W-sh/W-sh showed no increase in OVA-Alexa-positive DCs compared to nonsensitized mast cell-deficient animals. In sensitized Kit^W-sh/W-sh mice reconstituted with bone marrow-derived mast cells (BMMCs), the number of OVA- Alexa-positive DCs was comparable to that in sensitized wild-type animals. However, transfer of allergen-exposed BMMCs to sensitized mice prior to airway challenge augmented airway inflammation similarly in wild-type and mast cell-deficient mice. In line with this, sensitization with allergen-pulsed DCs induced allergic airway disease independently of mast cells. <i>Conclusions:</i> This study shows an interaction between mast cells and DCs following allergen challenge in sensitized hosts. However, the function of mast cells can be bypassed in models utilizing activated allergen-exposed DCs to initiate the development of allergic airway disease." @default.
• W2055937035 created "2016-06-24" @default.
• W2055937035 creator A5011297158 @default.
• W2055937035 creator A5017432226 @default.
• W2055937035 creator A5029503227 @default.
• W2055937035 creator A5040230220 @default.
• W2055937035 creator A5051240779 @default.
• W2055937035 creator A5053832875 @default.
• W2055937035 creator A5057741229 @default.
• W2055937035 creator A5074197659 @default.
• W2055937035 creator A5075095649 @default.
• W2055937035 creator A5088104836 @default.
• W2055937035 date "2009-09-29" @default.
• W2055937035 modified "2023-10-03" @default.
• W2055937035 title "Mast Cells Induce Migration of Dendritic Cells in a Murine Model of Acute Allergic Airway Disease" @default.
• W2055937035 cites W1554640891 @default.
• W2055937035 cites W1561018825 @default.
• W2055937035 cites W1573376333 @default.
• W2055937035 cites W1682127762 @default.
• W2055937035 cites W1718245819 @default.
• W2055937035 cites W1948549710 @default.
• W2055937035 cites W1964924481 @default.
• W2055937035 cites W1983662907 @default.
• W2055937035 cites W1995357195 @default.
• W2055937035 cites W1997967342 @default.
• W2055937035 cites W2001046185 @default.
• W2055937035 cites W2002375125 @default.
• W2055937035 cites W2024523289 @default.
• W2055937035 cites W2039252747 @default.
• W2055937035 cites W2042736312 @default.
• W2055937035 cites W2043546340 @default.
• W2055937035 cites W2050601356 @default.
• W2055937035 cites W2064464816 @default.
• W2055937035 cites W2091039798 @default.
• W2055937035 cites W2096379150 @default.
• W2055937035 cites W2097750657 @default.
• W2055937035 cites W2109537033 @default.
• W2055937035 cites W2109958057 @default.
• W2055937035 cites W2117254494 @default.
• W2055937035 cites W2140117437 @default.
• W2055937035 cites W2143036393 @default.
• W2055937035 cites W2151623302 @default.
• W2055937035 cites W2152044788 @default.
• W2055937035 cites W2164522180 @default.
• W2055937035 doi "https://doi.org/10.1159/000242359" @default.
• W2055937035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19786802" @default.
• W2055937035 hasPublicationYear "2009" @default.
• W2055937035 type Work @default.
• W2055937035 sameAs 2055937035 @default.
• W2055937035 citedByCount "26" @default.
• W2055937035 countsByYear W20559370352012 @default.
• W2055937035 countsByYear W20559370352013 @default.
• W2055937035 countsByYear W20559370352014 @default.
• W2055937035 countsByYear W20559370352015 @default.
• W2055937035 countsByYear W20559370352016 @default.
• W2055937035 countsByYear W20559370352017 @default.
• W2055937035 countsByYear W20559370352019 @default.
• W2055937035 countsByYear W20559370352021 @default.
• W2055937035 countsByYear W20559370352022 @default.
• W2055937035 countsByYear W20559370352023 @default.
• W2055937035 crossrefType "journal-article" @default.
• W2055937035 hasAuthorship W2055937035A5011297158 @default.
• W2055937035 hasAuthorship W2055937035A5017432226 @default.
• W2055937035 hasAuthorship W2055937035A5029503227 @default.
• W2055937035 hasAuthorship W2055937035A5040230220 @default.
• W2055937035 hasAuthorship W2055937035A5051240779 @default.
• W2055937035 hasAuthorship W2055937035A5053832875 @default.
• W2055937035 hasAuthorship W2055937035A5057741229 @default.
• W2055937035 hasAuthorship W2055937035A5074197659 @default.
• W2055937035 hasAuthorship W2055937035A5075095649 @default.
• W2055937035 hasAuthorship W2055937035A5088104836 @default.
• W2055937035 hasBestOaLocation W20559370351 @default.
• W2055937035 hasConcept C142724271 @default.
• W2055937035 hasConcept C153911025 @default.
• W2055937035 hasConcept C185592680 @default.
• W2055937035 hasConcept C203014093 @default.
• W2055937035 hasConcept C2776217527 @default.
• W2055937035 hasConcept C2778170410 @default.
• W2055937035 hasConcept C2779720271 @default.
• W2055937035 hasConcept C2779726688 @default.
• W2055937035 hasConcept C71924100 @default.
• W2055937035 hasConcept C86803240 @default.
• W2055937035 hasConcept C8891405 @default.
• W2055937035 hasConceptScore W2055937035C142724271 @default.
• W2055937035 hasConceptScore W2055937035C153911025 @default.
• W2055937035 hasConceptScore W2055937035C185592680 @default.
• W2055937035 hasConceptScore W2055937035C203014093 @default.
• W2055937035 hasConceptScore W2055937035C2776217527 @default.
• W2055937035 hasConceptScore W2055937035C2778170410 @default.
• W2055937035 hasConceptScore W2055937035C2779720271 @default.
• W2055937035 hasConceptScore W2055937035C2779726688 @default.
• W2055937035 hasConceptScore W2055937035C71924100 @default.
• W2055937035 hasConceptScore W2055937035C86803240 @default.
• W2055937035 hasConceptScore W2055937035C8891405 @default.
• W2055937035 hasIssue "3" @default.
• W2055937035 hasLocation W20559370351 @default.
• W2055937035 hasLocation W20559370352 @default.
• W2055937035 hasOpenAccess W2055937035 @default.

• next