FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055955438> ?p ?o ?g. }

• W2055955438 endingPage "1492" @default.
• W2055955438 startingPage "1484" @default.
• W2055955438 abstract "Paracoccidioides brasiliensis is a thermo-dimorphic fungus responsible for paracoccidioidomycosis (PCM), a systemic granulomatous mycosis prevalent in Latin America. The fungus releases many antigens which may be transiently bound to its cell surface. Some of them may show enzymatic functions essential for maintaining many cell processes and survival of the microorganism at different conditions. In this study, we report the characterization of a secreted 75kDa protein from P. brasiliensis with phosphatase activity. Biologic function of the molecule was demonstrated using two specific mAbs produced and characterized as IgM and IgG isotypes. Confocal microscopy and flow cytometry analysis demonstrated that both mAbs recognized the protein on the fungus surface, mainly in its budding sites. In vitro experiments showed that fungal growth was inhibited by blocking the protein with mAbs. In addition, opsonized yeast cells with both mAbs facilitated phagocytosis by murine peritoneal macrophages. Passive immunization using mAbs before P. brasiliensis mice infection reduced colony-forming units (CFU) in the lungs as compared with controls. Histopathology showed smaller inflammation, absence of yeast cells and no granuloma formation." @default.
• W2055955438 created "2016-06-24" @default.
• W2055955438 creator A5001921795 @default.
• W2055955438 creator A5008545303 @default.
• W2055955438 creator A5023286442 @default.
• W2055955438 creator A5044571542 @default.
• W2055955438 creator A5065453303 @default.
• W2055955438 creator A5077322009 @default.
• W2055955438 creator A5082212295 @default.
• W2055955438 creator A5087180136 @default.
• W2055955438 creator A5090482858 @default.
• W2055955438 date "2007-10-01" @default.
• W2055955438 modified "2023-10-16" @default.
• W2055955438 title "A surface 75-kDa protein with acid phosphatase activity recognized by monoclonal antibodies that inhibit Paracoccidioides brasiliensis growth" @default.
• W2055955438 cites W1606423922 @default.
• W2055955438 cites W1909278526 @default.
• W2055955438 cites W1954993407 @default.
• W2055955438 cites W1964576347 @default.
• W2055955438 cites W1965606695 @default.
• W2055955438 cites W1977112775 @default.
• W2055955438 cites W1982984484 @default.
• W2055955438 cites W1992274022 @default.
• W2055955438 cites W2023179030 @default.
• W2055955438 cites W2038719636 @default.
• W2055955438 cites W2050964657 @default.
• W2055955438 cites W2053624346 @default.
• W2055955438 cites W2053697748 @default.
• W2055955438 cites W2074387820 @default.
• W2055955438 cites W2075545728 @default.
• W2055955438 cites W2079831739 @default.
• W2055955438 cites W2088075996 @default.
• W2055955438 cites W2100837269 @default.
• W2055955438 cites W2112446302 @default.
• W2055955438 cites W2116871349 @default.
• W2055955438 cites W2120712476 @default.
• W2055955438 cites W2130069054 @default.
• W2055955438 cites W2130125263 @default.
• W2055955438 cites W2130316063 @default.
• W2055955438 cites W2169011707 @default.
• W2055955438 cites W2171947921 @default.
• W2055955438 cites W4293247451 @default.
• W2055955438 doi "https://doi.org/10.1016/j.micinf.2007.08.001" @default.
• W2055955438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17913543" @default.
• W2055955438 hasPublicationYear "2007" @default.
• W2055955438 type Work @default.
• W2055955438 sameAs 2055955438 @default.
• W2055955438 citedByCount "30" @default.
• W2055955438 countsByYear W20559554382012 @default.
• W2055955438 countsByYear W20559554382013 @default.
• W2055955438 countsByYear W20559554382014 @default.
• W2055955438 countsByYear W20559554382015 @default.
• W2055955438 countsByYear W20559554382016 @default.
• W2055955438 countsByYear W20559554382018 @default.
• W2055955438 countsByYear W20559554382019 @default.
• W2055955438 countsByYear W20559554382020 @default.
• W2055955438 countsByYear W20559554382021 @default.
• W2055955438 countsByYear W20559554382023 @default.
• W2055955438 crossrefType "journal-article" @default.
• W2055955438 hasAuthorship W2055955438A5001921795 @default.
• W2055955438 hasAuthorship W2055955438A5008545303 @default.
• W2055955438 hasAuthorship W2055955438A5023286442 @default.
• W2055955438 hasAuthorship W2055955438A5044571542 @default.
• W2055955438 hasAuthorship W2055955438A5065453303 @default.
• W2055955438 hasAuthorship W2055955438A5077322009 @default.
• W2055955438 hasAuthorship W2055955438A5082212295 @default.
• W2055955438 hasAuthorship W2055955438A5087180136 @default.
• W2055955438 hasAuthorship W2055955438A5090482858 @default.
• W2055955438 hasConcept C147483822 @default.
• W2055955438 hasConcept C153911025 @default.
• W2055955438 hasConcept C159654299 @default.
• W2055955438 hasConcept C160448771 @default.
• W2055955438 hasConcept C203014093 @default.
• W2055955438 hasConcept C21717790 @default.
• W2055955438 hasConcept C2777681368 @default.
• W2055955438 hasConcept C2779108831 @default.
• W2055955438 hasConcept C2779222958 @default.
• W2055955438 hasConcept C2909986799 @default.
• W2055955438 hasConcept C542903549 @default.
• W2055955438 hasConcept C553184892 @default.
• W2055955438 hasConcept C55493867 @default.
• W2055955438 hasConcept C86803240 @default.
• W2055955438 hasConcept C89423630 @default.
• W2055955438 hasConceptScore W2055955438C147483822 @default.
• W2055955438 hasConceptScore W2055955438C153911025 @default.
• W2055955438 hasConceptScore W2055955438C159654299 @default.
• W2055955438 hasConceptScore W2055955438C160448771 @default.
• W2055955438 hasConceptScore W2055955438C203014093 @default.
• W2055955438 hasConceptScore W2055955438C21717790 @default.
• W2055955438 hasConceptScore W2055955438C2777681368 @default.
• W2055955438 hasConceptScore W2055955438C2779108831 @default.
• W2055955438 hasConceptScore W2055955438C2779222958 @default.
• W2055955438 hasConceptScore W2055955438C2909986799 @default.
• W2055955438 hasConceptScore W2055955438C542903549 @default.
• W2055955438 hasConceptScore W2055955438C553184892 @default.
• W2055955438 hasConceptScore W2055955438C55493867 @default.
• W2055955438 hasConceptScore W2055955438C86803240 @default.
• W2055955438 hasConceptScore W2055955438C89423630 @default.
• W2055955438 hasIssue "12-13" @default.

• next