FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055960053> ?p ?o ?g. }

• W2055960053 endingPage "762" @default.
• W2055960053 startingPage "748" @default.
• W2055960053 abstract "Myotonic dystrophy 2 (DM2) is a multisystem skeletal muscle disease caused by an expansion of tetranucleotide CCTG repeats, the transcription of which results in the accumulation of untranslated CCUG RNA. In this study, we report that CCUG repeats both bind to and misregulate the biological functions of cytoplasmic multiprotein complexes. Two CCUG-interacting complexes were subsequently purified and analyzed. A major component of one of the complexes was found to be the 20S catalytic core complex of the proteasome. The second complex was found to contain CUG triplet repeat RNA-binding protein 1 (CUGBP1) and the translation initiation factor eIF2. Consistent with the biological functions of the 20S proteasome and the CUGBP1-eIF2 complexes, the stability of short-lived proteins and the levels of the translational targets of CUGBP1 were shown to be elevated in DM2 myoblasts. We found that the overexpression of CCUG repeats in human myoblasts from unaffected patients, in C2C12 myoblasts, and in a DM2 mouse model alters protein translation and degradation, similar to the alterations observed in DM2 patients. Taken together, these findings show that RNA CCUG repeats misregulate protein turnover on both the levels of translation and proteasome-mediated protein degradation." @default.
• W2055960053 created "2016-06-24" @default.
• W2055960053 creator A5005790498 @default.
• W2055960053 creator A5025092766 @default.
• W2055960053 creator A5033164275 @default.
• W2055960053 creator A5037660184 @default.
• W2055960053 creator A5039404447 @default.
• W2055960053 creator A5040794773 @default.
• W2055960053 creator A5042776961 @default.
• W2055960053 creator A5052296132 @default.
• W2055960053 creator A5074566522 @default.
• W2055960053 creator A5077203716 @default.
• W2055960053 creator A5078830243 @default.
• W2055960053 date "2009-08-01" @default.
• W2055960053 modified "2023-10-18" @default.
• W2055960053 title "Expression of RNA CCUG Repeats Dysregulates Translation and Degradation of Proteins in Myotonic Dystrophy 2 Patients" @default.
• W2055960053 cites W1964008557 @default.
• W2055960053 cites W1976704802 @default.
• W2055960053 cites W1977510643 @default.
• W2055960053 cites W1988117352 @default.
• W2055960053 cites W1994674028 @default.
• W2055960053 cites W2008929289 @default.
• W2055960053 cites W2020334159 @default.
• W2055960053 cites W2021242983 @default.
• W2055960053 cites W2045953719 @default.
• W2055960053 cites W2057463531 @default.
• W2055960053 cites W2081280332 @default.
• W2055960053 cites W2081748748 @default.
• W2055960053 cites W2087225941 @default.
• W2055960053 cites W2088489316 @default.
• W2055960053 cites W2093889952 @default.
• W2055960053 cites W2096966529 @default.
• W2055960053 cites W2099039583 @default.
• W2055960053 cites W2112194054 @default.
• W2055960053 cites W2122776931 @default.
• W2055960053 cites W2127487162 @default.
• W2055960053 cites W2137944938 @default.
• W2055960053 cites W2140074138 @default.
• W2055960053 cites W2143106924 @default.
• W2055960053 cites W2167126768 @default.
• W2055960053 cites W2167616277 @default.
• W2055960053 cites W2171373304 @default.
• W2055960053 cites W2313778491 @default.
• W2055960053 doi "https://doi.org/10.2353/ajpath.2009.090047" @default.
• W2055960053 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2716970" @default.
• W2055960053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19590039" @default.
• W2055960053 hasPublicationYear "2009" @default.
• W2055960053 type Work @default.
• W2055960053 sameAs 2055960053 @default.
• W2055960053 citedByCount "73" @default.
• W2055960053 countsByYear W20559600532012 @default.
• W2055960053 countsByYear W20559600532013 @default.
• W2055960053 countsByYear W20559600532014 @default.
• W2055960053 countsByYear W20559600532015 @default.
• W2055960053 countsByYear W20559600532016 @default.
• W2055960053 countsByYear W20559600532017 @default.
• W2055960053 countsByYear W20559600532018 @default.
• W2055960053 countsByYear W20559600532019 @default.
• W2055960053 countsByYear W20559600532020 @default.
• W2055960053 countsByYear W20559600532021 @default.
• W2055960053 countsByYear W20559600532022 @default.
• W2055960053 countsByYear W20559600532023 @default.
• W2055960053 crossrefType "journal-article" @default.
• W2055960053 hasAuthorship W2055960053A5005790498 @default.
• W2055960053 hasAuthorship W2055960053A5025092766 @default.
• W2055960053 hasAuthorship W2055960053A5033164275 @default.
• W2055960053 hasAuthorship W2055960053A5037660184 @default.
• W2055960053 hasAuthorship W2055960053A5039404447 @default.
• W2055960053 hasAuthorship W2055960053A5040794773 @default.
• W2055960053 hasAuthorship W2055960053A5042776961 @default.
• W2055960053 hasAuthorship W2055960053A5052296132 @default.
• W2055960053 hasAuthorship W2055960053A5074566522 @default.
• W2055960053 hasAuthorship W2055960053A5077203716 @default.
• W2055960053 hasAuthorship W2055960053A5078830243 @default.
• W2055960053 hasBestOaLocation W20559600531 @default.
• W2055960053 hasConcept C104317684 @default.
• W2055960053 hasConcept C105580179 @default.
• W2055960053 hasConcept C138885662 @default.
• W2055960053 hasConcept C149364088 @default.
• W2055960053 hasConcept C153911025 @default.
• W2055960053 hasConcept C179926584 @default.
• W2055960053 hasConcept C27740335 @default.
• W2055960053 hasConcept C2778063965 @default.
• W2055960053 hasConcept C3675279 @default.
• W2055960053 hasConcept C41282012 @default.
• W2055960053 hasConcept C41895202 @default.
• W2055960053 hasConcept C54355233 @default.
• W2055960053 hasConcept C67705224 @default.
• W2055960053 hasConcept C86803240 @default.
• W2055960053 hasConcept C89604277 @default.
• W2055960053 hasConcept C95444343 @default.
• W2055960053 hasConceptScore W2055960053C104317684 @default.
• W2055960053 hasConceptScore W2055960053C105580179 @default.
• W2055960053 hasConceptScore W2055960053C138885662 @default.
• W2055960053 hasConceptScore W2055960053C149364088 @default.
• W2055960053 hasConceptScore W2055960053C153911025 @default.
• W2055960053 hasConceptScore W2055960053C179926584 @default.
• W2055960053 hasConceptScore W2055960053C27740335 @default.

• next