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- W2055961276 abstract "This chapter discusses the physical properties, spectrometry, solution properties, and analysis of estrone. It also provides an overview of its biosynthesis and metabolism. The basic skeletal structure of estrone is the cyclopentanoperhydrophenanthrene nucleus. This nucleus is composed of four rings, designatedas A, B, C, and D. In vitro studies have shown that estrone arises from acetate. After several nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent condensation reactions, acetate forms squalene, which subsequently undergoes elimination and cyclization to yield cholesterol. The cleavage of the side chain of cholesterol and several rearrangements yield pregnenolone. Oxidation and isomerization produce progesterone, which leads to 4-androstene-3, 17-dione and finally to estrone. During the synthesis and metabolism, the addition or removal of hydrogen is catalyzed by enzymes found in the ovary. The addition of oxygen is catalyzed by hydroxylases, usually taking place in the liver and kidney, which are important sites for the inactivation of steroids. During the metabolism of estrone, a rapid equilibrium is established among estrone, estriol, and 17S-estradiol." @default.
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- W2055961276 date "1964-09-01" @default.
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- W2055961276 title "The gas chromatographic separation of sub-microgram amounts of sex steroids" @default.
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- W2055961276 doi "https://doi.org/10.1016/0039-128x(64)90152-7" @default.
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