FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055962814> ?p ?o ?g. }

• W2055962814 endingPage "1836" @default.
• W2055962814 startingPage "1827" @default.
• W2055962814 abstract "Idiopathic pulmonary fibrosis (IPF) is a progressive disorder characterized by inflammation, fibroblast proliferation, and accumulation of extracellular matrix proteins. Leukotrienes (LTs) are pro-inflammatory and pro-fibrogenic mediators derived from the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism. They are thought to play a role in a number of disease processes, but have received relatively little attention in investigations into the pathogenesis of IPF. In this study, we measured the levels of immunoreactive LTs B(4) and C(4) in homogenates of lung tissue obtained from patients with newly diagnosed, untreated IPF, as compared to levels measured in homogenates of uninvolved nonfibrotic lung tissue from patients undergoing resectional surgery for bronchogenic carcinoma. Compared to homogenates on nonfibrotic control lung, homogenates from IPF patients contained 15-fold more LTB(4) and 5-fold more LTC(4). IPF homogenate levels of LTB(4) were significantly correlated with histologic indices of both inflammation (r=0.861) and fibrosis (r=0.926). Activation of 5-LO is known from in vitro studies to be associated with localization of the enzyme at the nuclear membrane. Immunohistochemical staining for 5-LO protein in alveolar macrophages (AMs) demonstrated that such an activated localization pattern was significantly more frequent in IPF lung (19.2+/-3.3% of cells) than in control lung (9.3+/-0.9%); this localization pattern was rarely seen (3.2%) in sections from a truly normal transplant donor lung. Consistent with these data, AMs obtained from IPF patients by bronchoalveolar lavage, purified by adherence, and cultured in the absence of a stimulus for 16 h elaborated significantly greater amounts of LTB(4) and LTC(4) than did control AMs obtained from normal volunteers. These data indicate that the 5-LO pathway is constitutively activated in the lungs of patients with IPF, and the AM represents at least one cellular source of LT overproduction in this disorder. We speculate that LTs participate in the pathogenesis of IPF, and their overproduction in this disorder may be amenable to specific pharmacotherapy." @default.
• W2055962814 created "2016-06-24" @default.
• W2055962814 creator A5024415440 @default.
• W2055962814 creator A5028531065 @default.
• W2055962814 creator A5028601000 @default.
• W2055962814 creator A5036301630 @default.
• W2055962814 creator A5068840488 @default.
• W2055962814 creator A5084604101 @default.
• W2055962814 date "1996-04-15" @default.
• W2055962814 modified "2023-10-16" @default.
• W2055962814 title "Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis." @default.
• W2055962814 cites W1509307264 @default.
• W2055962814 cites W1510381828 @default.
• W2055962814 cites W1533294856 @default.
• W2055962814 cites W1564614506 @default.
• W2055962814 cites W1573038981 @default.
• W2055962814 cites W1573542905 @default.
• W2055962814 cites W1639313500 @default.
• W2055962814 cites W1934205038 @default.
• W2055962814 cites W1942883321 @default.
• W2055962814 cites W1953360193 @default.
• W2055962814 cites W1964302399 @default.
• W2055962814 cites W1971306126 @default.
• W2055962814 cites W1971418747 @default.
• W2055962814 cites W1980832959 @default.
• W2055962814 cites W1982389776 @default.
• W2055962814 cites W1982407164 @default.
• W2055962814 cites W1989654322 @default.
• W2055962814 cites W1992938929 @default.
• W2055962814 cites W1993884809 @default.
• W2055962814 cites W1994730705 @default.
• W2055962814 cites W2006192600 @default.
• W2055962814 cites W2012244701 @default.
• W2055962814 cites W2013414651 @default.
• W2055962814 cites W2016869710 @default.
• W2055962814 cites W2019461733 @default.
• W2055962814 cites W2022724314 @default.
• W2055962814 cites W2023213942 @default.
• W2055962814 cites W2023437751 @default.
• W2055962814 cites W2024819037 @default.
• W2055962814 cites W2026435977 @default.
• W2055962814 cites W2037029487 @default.
• W2055962814 cites W2037727844 @default.
• W2055962814 cites W2038468255 @default.
• W2055962814 cites W2038575244 @default.
• W2055962814 cites W2046362689 @default.
• W2055962814 cites W20468255 @default.
• W2055962814 cites W2051271931 @default.
• W2055962814 cites W2051367990 @default.
• W2055962814 cites W2058661991 @default.
• W2055962814 cites W2061588012 @default.
• W2055962814 cites W2065788657 @default.
• W2055962814 cites W2066367045 @default.
• W2055962814 cites W2066762210 @default.
• W2055962814 cites W2087312253 @default.
• W2055962814 cites W2103401040 @default.
• W2055962814 cites W2104505088 @default.
• W2055962814 cites W2119597232 @default.
• W2055962814 cites W2121737195 @default.
• W2055962814 cites W2128635872 @default.
• W2055962814 cites W2137028783 @default.
• W2055962814 cites W2163458518 @default.
• W2055962814 cites W2163533080 @default.
• W2055962814 cites W2181517072 @default.
• W2055962814 cites W2280537487 @default.
• W2055962814 cites W2421220842 @default.
• W2055962814 cites W303679952 @default.
• W2055962814 cites W4250845720 @default.
• W2055962814 cites W2006567704 @default.
• W2055962814 doi "https://doi.org/10.1172/jci118612" @default.
• W2055962814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507250" @default.
• W2055962814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8621765" @default.
• W2055962814 hasPublicationYear "1996" @default.
• W2055962814 type Work @default.
• W2055962814 sameAs 2055962814 @default.
• W2055962814 citedByCount "177" @default.
• W2055962814 countsByYear W20559628142012 @default.
• W2055962814 countsByYear W20559628142013 @default.
• W2055962814 countsByYear W20559628142014 @default.
• W2055962814 countsByYear W20559628142015 @default.
• W2055962814 countsByYear W20559628142016 @default.
• W2055962814 countsByYear W20559628142017 @default.
• W2055962814 countsByYear W20559628142018 @default.
• W2055962814 countsByYear W20559628142019 @default.
• W2055962814 countsByYear W20559628142020 @default.
• W2055962814 countsByYear W20559628142021 @default.
• W2055962814 countsByYear W20559628142022 @default.
• W2055962814 countsByYear W20559628142023 @default.
• W2055962814 crossrefType "journal-article" @default.
• W2055962814 hasAuthorship W2055962814A5024415440 @default.
• W2055962814 hasAuthorship W2055962814A5028531065 @default.
• W2055962814 hasAuthorship W2055962814A5028601000 @default.
• W2055962814 hasAuthorship W2055962814A5036301630 @default.
• W2055962814 hasAuthorship W2055962814A5068840488 @default.
• W2055962814 hasAuthorship W2055962814A5084604101 @default.
• W2055962814 hasBestOaLocation W20559628141 @default.
• W2055962814 hasConcept C126322002 @default.
• W2055962814 hasConcept C142724271 @default.

• next