FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055976997> ?p ?o ?g. }

• W2055976997 endingPage "5810" @default.
• W2055976997 startingPage "5802" @default.
• W2055976997 abstract "During brain injury, extracellular adenosine and glutamate levels increase rapidly and dramatically. We hypothesized that local glutamate levels in the brain dictates the adenosine–adenosine A 2A receptor (A 2A R) effects on neuroinflammation and brain damage outcome. Here, we showed that, in the presence of low concentrations of glutamate, the A 2A R agonist 3-[4-[2-[[6-amino-9-[(2 R ,3 R ,4 S ,5 S )-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid (CGS21680) inhibited lipopolysaccharide (LPS)-induced nitric oxide synthase (NOS) activity of cultured microglial cells, an effect that was dependent on the protein kinase A (PKA) pathway. However, in high concentrations of glutamate, CGS21680 increased LPS-induced NOS activity in a protein kinase C (PKC)-dependent manner. Thus, increasing the local level of glutamate redirects A 2A R signaling from the PKA to the PKC pathway, resulting in a switch in A 2A R effects from antiinflammatory to proinflammatory. In a cortical impact model of traumatic brain injury (TBI) in mice, brain water contents, behavioral deficits, and expression of tumor necrosis factor-α, interleukin-1 mRNAs, and inducible NOS were attenuated by administering CGS21680 at post-TBI time when brain glutamate levels were low, or by administering the A 2A R antagonist ZM241385 [4-(2-{[5-amino-2-(2-furyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol] at post-TBI time when brain glutamate levels were elevated. Furthermore, pre-TBI treatment with the glutamate release inhibitor ( S )-4C3HPG [( S )-4-carboxy-3-hydroxyphenylglycine] converted the debilitating effect of CGS21680 administered at post-TBI time with high glutamate level to a neuroprotective effect. This further indicates that the switch in the effect of A 2A R activation in intact animals from antiinflammatory to proinflammatory is dependent on glutamate concentration. These findings identify a novel role for glutamate in modulation of neuroinflammation and brain injury via the adenosine–A 2A R system." @default.
• W2055976997 created "2016-06-24" @default.
• W2055976997 creator A5000432967 @default.
• W2055976997 creator A5005995304 @default.
• W2055976997 creator A5007940294 @default.
• W2055976997 creator A5012549429 @default.
• W2055976997 creator A5018780864 @default.
• W2055976997 creator A5042837947 @default.
• W2055976997 creator A5056796824 @default.
• W2055976997 creator A5060659459 @default.
• W2055976997 creator A5072159453 @default.
• W2055976997 creator A5073070877 @default.
• W2055976997 creator A5077153113 @default.
• W2055976997 creator A5083064427 @default.
• W2055976997 creator A5090904507 @default.
• W2055976997 date "2010-04-21" @default.
• W2055976997 modified "2023-10-12" @default.
• W2055976997 title "Local Glutamate Level Dictates Adenosine A_2AReceptor Regulation of Neuroinflammation and Traumatic Brain Injury" @default.
• W2055976997 cites W1551550807 @default.
• W2055976997 cites W1579287598 @default.
• W2055976997 cites W1670130194 @default.
• W2055976997 cites W1969515810 @default.
• W2055976997 cites W1971145051 @default.
• W2055976997 cites W1971346018 @default.
• W2055976997 cites W1975614861 @default.
• W2055976997 cites W1980218345 @default.
• W2055976997 cites W1983934270 @default.
• W2055976997 cites W1985407729 @default.
• W2055976997 cites W1985962152 @default.
• W2055976997 cites W1993653752 @default.
• W2055976997 cites W1994638214 @default.
• W2055976997 cites W1994873358 @default.
• W2055976997 cites W1995287360 @default.
• W2055976997 cites W1995807191 @default.
• W2055976997 cites W1999869745 @default.
• W2055976997 cites W2000703659 @default.
• W2055976997 cites W2003146704 @default.
• W2055976997 cites W2003847227 @default.
• W2055976997 cites W2005997117 @default.
• W2055976997 cites W2007127551 @default.
• W2055976997 cites W2007620493 @default.
• W2055976997 cites W2008871586 @default.
• W2055976997 cites W2010114986 @default.
• W2055976997 cites W2012568607 @default.
• W2055976997 cites W2014739886 @default.
• W2055976997 cites W2016036161 @default.
• W2055976997 cites W2020842252 @default.
• W2055976997 cites W2025376985 @default.
• W2055976997 cites W2046338009 @default.
• W2055976997 cites W2049149064 @default.
• W2055976997 cites W2056083897 @default.
• W2055976997 cites W2059620437 @default.
• W2055976997 cites W2060183829 @default.
• W2055976997 cites W2061928399 @default.
• W2055976997 cites W2066143615 @default.
• W2055976997 cites W2067633386 @default.
• W2055976997 cites W2068187607 @default.
• W2055976997 cites W2069373867 @default.
• W2055976997 cites W2073909805 @default.
• W2055976997 cites W2079772923 @default.
• W2055976997 cites W2095931805 @default.
• W2055976997 cites W2104084108 @default.
• W2055976997 cites W2113127684 @default.
• W2055976997 cites W2114901294 @default.
• W2055976997 cites W2129667982 @default.
• W2055976997 cites W2130302474 @default.
• W2055976997 cites W2137682703 @default.
• W2055976997 cites W2139064018 @default.
• W2055976997 cites W2145529172 @default.
• W2055976997 cites W2163629140 @default.
• W2055976997 cites W2170936621 @default.
• W2055976997 cites W3087885511 @default.
• W2055976997 cites W4296025734 @default.
• W2055976997 cites W4322696962 @default.
• W2055976997 doi "https://doi.org/10.1523/jneurosci.0268-10.2010" @default.
• W2055976997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3842468" @default.
• W2055976997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410132" @default.
• W2055976997 hasPublicationYear "2010" @default.
• W2055976997 type Work @default.
• W2055976997 sameAs 2055976997 @default.
• W2055976997 citedByCount "139" @default.
• W2055976997 countsByYear W20559769972012 @default.
• W2055976997 countsByYear W20559769972013 @default.
• W2055976997 countsByYear W20559769972014 @default.
• W2055976997 countsByYear W20559769972015 @default.
• W2055976997 countsByYear W20559769972016 @default.
• W2055976997 countsByYear W20559769972017 @default.
• W2055976997 countsByYear W20559769972018 @default.
• W2055976997 countsByYear W20559769972019 @default.
• W2055976997 countsByYear W20559769972020 @default.
• W2055976997 countsByYear W20559769972021 @default.
• W2055976997 countsByYear W20559769972022 @default.
• W2055976997 countsByYear W20559769972023 @default.
• W2055976997 crossrefType "journal-article" @default.
• W2055976997 hasAuthorship W2055976997A5000432967 @default.
• W2055976997 hasAuthorship W2055976997A5005995304 @default.
• W2055976997 hasAuthorship W2055976997A5007940294 @default.
• W2055976997 hasAuthorship W2055976997A5012549429 @default.

• next