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- W2055980504 abstract "In the yeast Saccharomyces cerevisiae, the Rad6-Rad18 DNA damage tolerance pathway constitutes a major defense system against replication fork blocking DNA lesions. The Rad6-Rad18 ubiquitin-conjugating/ligase complex governs error-free and error-prone translesion synthesis by specialized DNA polymerases, as well as an error-free Rad5-dependent postreplicative repair pathway. For facilitating replication through DNA lesions, translesion synthesis polymerases copy directly from the damaged template, while the Rad5-dependent damage tolerance pathway obtains information from the newly synthesized strand of the undamaged sister duplex. Although genetic data demonstrate the importance of the Rad5-dependent pathway in tolerating DNA damages, there has been little understanding of its mechanism. Also, the conservation of the yeast Rad5-dependent pathway in higher order eukaryotic cells remained uncertain for a long time. Here we summarize findings published in recent years regarding the role of Rad5 in promoting error-free replication of damaged DNA, and we also discuss results obtained with its human orthologs, HLTF and SHPRH." @default.
- W2055980504 created "2016-06-24" @default.
- W2055980504 creator A5012866696 @default.
- W2055980504 creator A5017776028 @default.
- W2055980504 creator A5028343492 @default.
- W2055980504 creator A5031981833 @default.
- W2055980504 date "2010-03-02" @default.
- W2055980504 modified "2023-09-29" @default.
- W2055980504 title "Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance." @default.
- W2055980504 cites W1447147799 @default.
- W2055980504 cites W1535363390 @default.
- W2055980504 cites W1582044781 @default.
- W2055980504 cites W1776762721 @default.
- W2055980504 cites W1862915326 @default.
- W2055980504 cites W1966950471 @default.
- W2055980504 cites W1967625467 @default.
- W2055980504 cites W1973526911 @default.
- W2055980504 cites W1974875206 @default.
- W2055980504 cites W1981117129 @default.
- W2055980504 cites W1981833041 @default.
- W2055980504 cites W1982453626 @default.
- W2055980504 cites W1982782744 @default.
- W2055980504 cites W1983441877 @default.
- W2055980504 cites W1984036570 @default.
- W2055980504 cites W1984459901 @default.
- W2055980504 cites W1984842319 @default.
- W2055980504 cites W1986076535 @default.
- W2055980504 cites W1988617344 @default.
- W2055980504 cites W1989575399 @default.
- W2055980504 cites W1990906479 @default.
- W2055980504 cites W1991489744 @default.
- W2055980504 cites W1992036233 @default.
- W2055980504 cites W1992705591 @default.
- W2055980504 cites W1992705983 @default.
- W2055980504 cites W1995055406 @default.
- W2055980504 cites W1997698992 @default.
- W2055980504 cites W2004639615 @default.
- W2055980504 cites W2006014633 @default.
- W2055980504 cites W2006730106 @default.
- W2055980504 cites W2009542739 @default.
- W2055980504 cites W2010516573 @default.
- W2055980504 cites W2011580988 @default.
- W2055980504 cites W2013289317 @default.
- W2055980504 cites W2013915902 @default.
- W2055980504 cites W2014989563 @default.
- W2055980504 cites W2018179063 @default.
- W2055980504 cites W2020136215 @default.
- W2055980504 cites W2021072381 @default.
- W2055980504 cites W2022148699 @default.
- W2055980504 cites W2023158598 @default.
- W2055980504 cites W2028767678 @default.
- W2055980504 cites W2037909746 @default.
- W2055980504 cites W2039693737 @default.
- W2055980504 cites W2041840396 @default.
- W2055980504 cites W2045887257 @default.
- W2055980504 cites W2046066638 @default.
- W2055980504 cites W2053960414 @default.
- W2055980504 cites W2054918042 @default.
- W2055980504 cites W2055667487 @default.
- W2055980504 cites W2056139483 @default.
- W2055980504 cites W2060431990 @default.
- W2055980504 cites W2062487397 @default.
- W2055980504 cites W2063240589 @default.
- W2055980504 cites W2065826174 @default.
- W2055980504 cites W2067748326 @default.
- W2055980504 cites W2070910548 @default.
- W2055980504 cites W2071843243 @default.
- W2055980504 cites W2073294832 @default.
- W2055980504 cites W2079283952 @default.
- W2055980504 cites W2079846350 @default.
- W2055980504 cites W2083546232 @default.
- W2055980504 cites W2084303694 @default.
- W2055980504 cites W2085866527 @default.
- W2055980504 cites W2091098505 @default.
- W2055980504 cites W2091778396 @default.
- W2055980504 cites W2098824335 @default.
- W2055980504 cites W2100974599 @default.
- W2055980504 cites W2101101375 @default.
- W2055980504 cites W2105356590 @default.
- W2055980504 cites W2106204166 @default.
- W2055980504 cites W2109247109 @default.
- W2055980504 cites W2110966169 @default.
- W2055980504 cites W2113224775 @default.
- W2055980504 cites W2115534366 @default.
- W2055980504 cites W2116468279 @default.
- W2055980504 cites W2117502397 @default.
- W2055980504 cites W2118342658 @default.
- W2055980504 cites W2119301405 @default.
- W2055980504 cites W2121993095 @default.
- W2055980504 cites W2126830955 @default.
- W2055980504 cites W2128438064 @default.
- W2055980504 cites W2131510695 @default.
- W2055980504 cites W2138122869 @default.
- W2055980504 cites W2140336382 @default.
- W2055980504 cites W2142513901 @default.
- W2055980504 cites W2143064529 @default.
- W2055980504 cites W2145269684 @default.
- W2055980504 cites W2150915103 @default.