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- W2055983229 abstract "High intensity focused ultrasound (HIFU) is a non-invasive technique for treating soft tissue tumors. A feasibility study for using the photoacoustic (PA) effect to monitor in-situ temperature changes during HIFU exposures is presented. A PA wave is generated from the thermoelastic expansion of a light-absorbing medium with its amplitude related to the Grüneisen parameter of the medium, which, for water, depends linearly on temperature. A 2-MHz HIFU transducer heated a cylindrical graphite inclusion in which a wire thermocouple was embedded. A 532-nm pulsed laser illuminated the inclusion at a rate of 10 Hz, and a 15-MHz passive transducer monitored the PA response throughout the 30-s exposure. Singular-value-decomposition analysis of the PA response was performed to extract the contribution from temperature change. Thermocouple measurements indicated a temperature increase from 22–60 °C, depending on the HIFU intensity employed, with a concomitant 20%–30% increase in PA amplitude. PA-based temperature curves correlated with the thermocouple measurements (rms deviation <5 °C). This technique tracked both the heating and cooling phases of the HIFU exposure and potentially could be used to noninvasively monitor in-situ temperature in real-time during HIFU. [Work supported by a Boston University Dean’s Catalyst Award and the RRI’s Biomedical Engineering Research Fund.]" @default.
- W2055983229 created "2016-06-24" @default.
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- W2055983229 date "2009-10-01" @default.
- W2055983229 modified "2023-09-27" @default.
- W2055983229 title "The use of the photoacoustic effect for non-invasive temperature monitoring during high intensity focused ultrasound exposures." @default.
- W2055983229 doi "https://doi.org/10.1121/1.3249199" @default.
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