FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055985540> ?p ?o ?g. }

• W2055985540 endingPage "1110" @default.
• W2055985540 startingPage "1103" @default.
• W2055985540 abstract "Regulation of the cysteine transporter known as excitatory amino acid carrier-1 (EAAC1) for intracellular glutathione (GSH) content was investigated using human embryonic kidney (HEK) 293 cells as a model system. GSH content was significantly reduced by l-aspartate-beta-hydroxamate (50-250 microM), an inhibitor of both EAAC1 and GLT1, both of which are transporters to take up cysteine, whereas dihydrokainate (1-100 microM), a specific inhibitor of GLT1, failed to do so. This indicates that EAAC1 is involved in GSH content in HEK293 cells. We examined the effect of glutamate transport-associated protein 3-18 (GTRAP3-18), which is capable of interacting with EAAC1. The GSH content decreased when the GTRAP3-18 protein level at the plasma membrane was increased by methyl-beta-cyclodextrin (250 microM), rendering the cells more vulnerable to oxidative stress. Intracellular GSH increased when the GTRAP3-18 protein level at the plasma membrane was decreased by antisense oligonucleotides, rendering the cells more resistant to oxidative stress. Furthermore, we found that the increase in GSH content produced by stimulating protein kinase C, a translocator and activator of EAAC1, was inhibited by an increase in cell surface GTRAP3-18 protein. These results show GTRAP3-18 to negatively and dominantly regulate cellular GSH content via interaction with EAAC1 at the plasma membrane." @default.
• W2055985540 created "2016-06-24" @default.
• W2055985540 creator A5026416376 @default.
• W2055985540 creator A5049218617 @default.
• W2055985540 creator A5056830396 @default.
• W2055985540 date "2007-07-23" @default.
• W2055985540 modified "2023-09-23" @default.
• W2055985540 title "Regulation of Glutathione Synthesis via Interaction between Glutamate Transport-Associated Protein 3-18 (GTRAP3-18) and Excitatory Amino Acid Carrier-1 (EAAC1) at Plasma Membrane" @default.
• W2055985540 cites W1506990787 @default.
• W2055985540 cites W1525431558 @default.
• W2055985540 cites W1664703379 @default.
• W2055985540 cites W1679707639 @default.
• W2055985540 cites W1968513905 @default.
• W2055985540 cites W1969400861 @default.
• W2055985540 cites W1969924717 @default.
• W2055985540 cites W1979234150 @default.
• W2055985540 cites W1983968962 @default.
• W2055985540 cites W1986849641 @default.
• W2055985540 cites W1997727568 @default.
• W2055985540 cites W2002366377 @default.
• W2055985540 cites W2003410399 @default.
• W2055985540 cites W2010131630 @default.
• W2055985540 cites W2014724435 @default.
• W2055985540 cites W2022028849 @default.
• W2055985540 cites W2026519847 @default.
• W2055985540 cites W2034219543 @default.
• W2055985540 cites W2034703968 @default.
• W2055985540 cites W2035360955 @default.
• W2055985540 cites W2041231069 @default.
• W2055985540 cites W2056033864 @default.
• W2055985540 cites W2058382351 @default.
• W2055985540 cites W2064388113 @default.
• W2055985540 cites W2067775247 @default.
• W2055985540 cites W2068473477 @default.
• W2055985540 cites W2075185645 @default.
• W2055985540 cites W2078339523 @default.
• W2055985540 cites W2080463775 @default.
• W2055985540 cites W2085222910 @default.
• W2055985540 cites W2093140151 @default.
• W2055985540 cites W2095267065 @default.
• W2055985540 cites W2117029515 @default.
• W2055985540 cites W2143373379 @default.
• W2055985540 cites W2154297004 @default.
• W2055985540 cites W2165731491 @default.
• W2055985540 cites W2169714384 @default.
• W2055985540 cites W4210979710 @default.
• W2055985540 doi "https://doi.org/10.1124/mol.107.039461" @default.
• W2055985540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17646425" @default.
• W2055985540 hasPublicationYear "2007" @default.
• W2055985540 type Work @default.
• W2055985540 sameAs 2055985540 @default.
• W2055985540 citedByCount "38" @default.
• W2055985540 countsByYear W20559855402012 @default.
• W2055985540 countsByYear W20559855402013 @default.
• W2055985540 countsByYear W20559855402014 @default.
• W2055985540 countsByYear W20559855402015 @default.
• W2055985540 countsByYear W20559855402017 @default.
• W2055985540 countsByYear W20559855402018 @default.
• W2055985540 countsByYear W20559855402019 @default.
• W2055985540 countsByYear W20559855402020 @default.
• W2055985540 countsByYear W20559855402021 @default.
• W2055985540 countsByYear W20559855402022 @default.
• W2055985540 countsByYear W20559855402023 @default.
• W2055985540 crossrefType "journal-article" @default.
• W2055985540 hasAuthorship W2055985540A5026416376 @default.
• W2055985540 hasAuthorship W2055985540A5049218617 @default.
• W2055985540 hasAuthorship W2055985540A5056830396 @default.
• W2055985540 hasConcept C104317684 @default.
• W2055985540 hasConcept C149011108 @default.
• W2055985540 hasConcept C170493617 @default.
• W2055985540 hasConcept C174510640 @default.
• W2055985540 hasConcept C181199279 @default.
• W2055985540 hasConcept C185592680 @default.
• W2055985540 hasConcept C2776151105 @default.
• W2055985540 hasConcept C2777476445 @default.
• W2055985540 hasConcept C2779201268 @default.
• W2055985540 hasConcept C515207424 @default.
• W2055985540 hasConcept C538909803 @default.
• W2055985540 hasConcept C55493867 @default.
• W2055985540 hasConcept C61174792 @default.
• W2055985540 hasConcept C79879829 @default.
• W2055985540 hasConcept C86803240 @default.
• W2055985540 hasConceptScore W2055985540C104317684 @default.
• W2055985540 hasConceptScore W2055985540C149011108 @default.
• W2055985540 hasConceptScore W2055985540C170493617 @default.
• W2055985540 hasConceptScore W2055985540C174510640 @default.
• W2055985540 hasConceptScore W2055985540C181199279 @default.
• W2055985540 hasConceptScore W2055985540C185592680 @default.
• W2055985540 hasConceptScore W2055985540C2776151105 @default.
• W2055985540 hasConceptScore W2055985540C2777476445 @default.
• W2055985540 hasConceptScore W2055985540C2779201268 @default.
• W2055985540 hasConceptScore W2055985540C515207424 @default.
• W2055985540 hasConceptScore W2055985540C538909803 @default.
• W2055985540 hasConceptScore W2055985540C55493867 @default.
• W2055985540 hasConceptScore W2055985540C61174792 @default.
• W2055985540 hasConceptScore W2055985540C79879829 @default.
• W2055985540 hasConceptScore W2055985540C86803240 @default.
• W2055985540 hasIssue "5" @default.

• next