Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055985807> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2055985807 endingPage "1747" @default.
- W2055985807 startingPage "1741" @default.
- W2055985807 abstract "We have previously demonstrated that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is an intestinal cytoprotective agent. The current study examined whether HB-EGF is effective as salvage therapy as well as prophylactic therapy for intestinal ischemia-reperfusion (I/R) injury, whether intravenous administration is as effective as intraluminal administration, and whether increased benefits are seen with increasing dose.Total midgut I/R injury in rats was achieved by occlusion of a first-order branch of the superior mesenteric artery for 60 minutes, followed by reperfusion for 6 hours. Rats were treated with HB-EGF 5 minutes before ischemia, halfway through the ischemic event, or 5 minutes after ischemia. Route of administration was tested by administering HB-EGF either intraluminally or intravenously. Seven different doses of HB-EGF were tested.Heparin-binding, EGF-like growth factor protected the intestine from injury when administered before injury and was also effective when administered during ischemia or even after injury. Intraluminal administration of HB-EGF was superior to intravenous administration. Increasing doses of HB-EGF resulted in a greater cytoprotective effect.These data demonstrate that HB-EGF acts as an effective intestinal cytoprotective agent when administered intraluminally not only before injury, but also during injury and, most importantly, even after intestinal injury has already occurred. These findings support a basis for the prophylactic use of intraluminal HB-EGF in high-risk patients, as well as for the administration of HB-EGF to salvage patients in whom an intestinal insult has already occurred." @default.
- W2055985807 created "2016-06-24" @default.
- W2055985807 creator A5036985706 @default.
- W2055985807 creator A5037689784 @default.
- W2055985807 creator A5046256982 @default.
- W2055985807 date "2005-11-01" @default.
- W2055985807 modified "2023-09-29" @default.
- W2055985807 title "Timing, route, and dose of administration of heparin-binding epidermal growth factor–like growth factor in protection against intestinal ischemia-reperfusion injury" @default.
- W2055985807 cites W1523182164 @default.
- W2055985807 cites W1595716544 @default.
- W2055985807 cites W1964493811 @default.
- W2055985807 cites W1985644541 @default.
- W2055985807 cites W1987428966 @default.
- W2055985807 cites W2010373786 @default.
- W2055985807 cites W2029409014 @default.
- W2055985807 cites W2030789072 @default.
- W2055985807 cites W2038086562 @default.
- W2055985807 cites W2054461815 @default.
- W2055985807 cites W2059699981 @default.
- W2055985807 cites W2066387478 @default.
- W2055985807 cites W2084558500 @default.
- W2055985807 cites W2094555854 @default.
- W2055985807 cites W2132499449 @default.
- W2055985807 cites W2172535935 @default.
- W2055985807 doi "https://doi.org/10.1016/j.jpedsurg.2005.07.064" @default.
- W2055985807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16291163" @default.
- W2055985807 hasPublicationYear "2005" @default.
- W2055985807 type Work @default.
- W2055985807 sameAs 2055985807 @default.
- W2055985807 citedByCount "12" @default.
- W2055985807 countsByYear W20559858072014 @default.
- W2055985807 countsByYear W20559858072015 @default.
- W2055985807 countsByYear W20559858072019 @default.
- W2055985807 countsByYear W20559858072020 @default.
- W2055985807 crossrefType "journal-article" @default.
- W2055985807 hasAuthorship W2055985807A5036985706 @default.
- W2055985807 hasAuthorship W2055985807A5037689784 @default.
- W2055985807 hasAuthorship W2055985807A5046256982 @default.
- W2055985807 hasConcept C126322002 @default.
- W2055985807 hasConcept C159048773 @default.
- W2055985807 hasConcept C170493617 @default.
- W2055985807 hasConcept C2775960820 @default.
- W2055985807 hasConcept C2776362946 @default.
- W2055985807 hasConcept C2777557582 @default.
- W2055985807 hasConcept C2780114680 @default.
- W2055985807 hasConcept C2781046184 @default.
- W2055985807 hasConcept C42219234 @default.
- W2055985807 hasConcept C541997718 @default.
- W2055985807 hasConcept C71924100 @default.
- W2055985807 hasConcept C98274493 @default.
- W2055985807 hasConceptScore W2055985807C126322002 @default.
- W2055985807 hasConceptScore W2055985807C159048773 @default.
- W2055985807 hasConceptScore W2055985807C170493617 @default.
- W2055985807 hasConceptScore W2055985807C2775960820 @default.
- W2055985807 hasConceptScore W2055985807C2776362946 @default.
- W2055985807 hasConceptScore W2055985807C2777557582 @default.
- W2055985807 hasConceptScore W2055985807C2780114680 @default.
- W2055985807 hasConceptScore W2055985807C2781046184 @default.
- W2055985807 hasConceptScore W2055985807C42219234 @default.
- W2055985807 hasConceptScore W2055985807C541997718 @default.
- W2055985807 hasConceptScore W2055985807C71924100 @default.
- W2055985807 hasConceptScore W2055985807C98274493 @default.
- W2055985807 hasIssue "11" @default.
- W2055985807 hasLocation W20559858071 @default.
- W2055985807 hasLocation W20559858072 @default.
- W2055985807 hasOpenAccess W2055985807 @default.
- W2055985807 hasPrimaryLocation W20559858071 @default.
- W2055985807 hasRelatedWork W196898746 @default.
- W2055985807 hasRelatedWork W1998358446 @default.
- W2055985807 hasRelatedWork W2020521634 @default.
- W2055985807 hasRelatedWork W2025180610 @default.
- W2055985807 hasRelatedWork W2071073667 @default.
- W2055985807 hasRelatedWork W2113961688 @default.
- W2055985807 hasRelatedWork W2144899041 @default.
- W2055985807 hasRelatedWork W2148506302 @default.
- W2055985807 hasRelatedWork W2473921159 @default.
- W2055985807 hasRelatedWork W349272906 @default.
- W2055985807 hasVolume "40" @default.
- W2055985807 isParatext "false" @default.
- W2055985807 isRetracted "false" @default.
- W2055985807 magId "2055985807" @default.
- W2055985807 workType "article" @default.