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- W2055993989 abstract "Abstract Natural killing of two human leukemia cell lines (K562 and Molt 4) in a soft-agar, clonagenic assay was shown to be the result of two opposite yet concurrent processes: target cell colony stimulation and inhibition. The stimulatory effect was demonstrable when the effector lymphocytes and target cells were separated in contiguous agar layers, suggesting mediation by a soluble factor. Similarly, stimulation occurred when the effector lymphocytes and target cells were combined at low effector-target cell ratios that do not favor direct cell contact. Target colony inhibition was found to be dominant when large E:T ratios were employed. Both target-effector binding and natural killing were significantly reduced in medium devoid of divalent cations." @default.
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- W2055993989 date "1982-05-01" @default.
- W2055993989 modified "2023-09-26" @default.
- W2055993989 title "Opposing effects of human peripheral blood lymphocytes on the growth of cultured leukemia cell lines" @default.
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- W2055993989 doi "https://doi.org/10.1016/0008-8749(82)90080-6" @default.
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