FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2055994515> ?p ?o ?g. }

• W2055994515 endingPage "425" @default.
• W2055994515 startingPage "415" @default.
• W2055994515 abstract "Extracellular levels of dynorphin B were analysed with in vivo microdialysis in the neostriatum and substantia nigra of halothane-anaesthetized rats. Dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, as well as GABA were simultaneously monitored. Chromatographic analysis revealed that the dynorphin B-like immunoreactivity measured in perfusates collected under basal and K+-depolarizing conditions co-eluted with synthetic dynorphin B. Dynorphin B, GABA and dopamine levels were Ca2+-dependently increased by K+-depolarization, while 3,4-dihy-droxyphenylacetic acid and homovanillic acid levels were decreased. Dopamine and its metabolites, but not dynorphin B or GABA levels, were significantly decreased after a unilateral 6-hydroxydopamine injection into the left medial forebrain bundle. In contrast, following a unilateral injection of ibotenic acid into the striatum, dynorphin B and GABA levels were decreased by > 50% in striatum and substantia nigra on the lesioned side, whereas no significant changes were observed in basal dopamine levels. The inclusion of the peptidase inhibitor captopril (50–500 μM) into the nigral perfusion medium produced a concentration-dependent increase in nigral extracellular levels of dynorphin B. In the striatum, a delayed increase in dynorphin B and GABA levels could be observed following the nigral captopril administration, but this effect was not concentration-dependent. Thus, we demonstrate that extracellular levels of dynorphin B, dopamine and GABA can simultaneously be monitored with in vivo microdialysis. Extracellular dynorphin B appears to originate from neurons, since the levels were (i) increased in a Ca2+-dependent manner by K+-depolarization, and (ii) decreased by a selective lesion of the striatum, known to contain cell bodies of dynorphin neurons in the striatonigral pathway. Furthermore, (iii) the increase in nigral dynorphin B levels by peptidase inhibition suggests the presence of clearance mechanisms for the released dynorphin peptides." @default.
• W2055994515 created "2016-06-24" @default.
• W2055994515 creator A5010768248 @default.
• W2055994515 creator A5034314111 @default.
• W2055994515 creator A5053353441 @default.
• W2055994515 creator A5067628389 @default.
• W2055994515 creator A5081521018 @default.
• W2055994515 creator A5091798197 @default.
• W2055994515 date "1994-11-01" @default.
• W2055994515 modified "2023-10-18" @default.
• W2055994515 title "The striatonigral dynorphin pathway of the rat studied with In vivo microdialysis—I. Effects of K+-depolarization, lesions and peptidase inhibition" @default.
• W2055994515 cites W1546812311 @default.
• W2055994515 cites W1965058910 @default.
• W2055994515 cites W1965110152 @default.
• W2055994515 cites W1968494270 @default.
• W2055994515 cites W1970374596 @default.
• W2055994515 cites W1972246466 @default.
• W2055994515 cites W1975814998 @default.
• W2055994515 cites W1976806099 @default.
• W2055994515 cites W1976963429 @default.
• W2055994515 cites W1986232343 @default.
• W2055994515 cites W1988718959 @default.
• W2055994515 cites W1990096326 @default.
• W2055994515 cites W1990666973 @default.
• W2055994515 cites W1999864955 @default.
• W2055994515 cites W1999961963 @default.
• W2055994515 cites W2012458599 @default.
• W2055994515 cites W2013845131 @default.
• W2055994515 cites W2022233762 @default.
• W2055994515 cites W2024789581 @default.
• W2055994515 cites W2025023187 @default.
• W2055994515 cites W2030125510 @default.
• W2055994515 cites W2033057062 @default.
• W2055994515 cites W2045178401 @default.
• W2055994515 cites W2048243485 @default.
• W2055994515 cites W2048358976 @default.
• W2055994515 cites W2059392469 @default.
• W2055994515 cites W2062268242 @default.
• W2055994515 cites W2067071952 @default.
• W2055994515 cites W2070254367 @default.
• W2055994515 cites W2071702367 @default.
• W2055994515 cites W2071774239 @default.
• W2055994515 cites W2078169688 @default.
• W2055994515 cites W2082366294 @default.
• W2055994515 cites W2084457415 @default.
• W2055994515 cites W2090899284 @default.
• W2055994515 cites W2091741039 @default.
• W2055994515 cites W2100869641 @default.
• W2055994515 cites W2113449040 @default.
• W2055994515 cites W2114627898 @default.
• W2055994515 cites W2118991951 @default.
• W2055994515 cites W2122946342 @default.
• W2055994515 cites W2124793782 @default.
• W2055994515 cites W3161769974 @default.
• W2055994515 doi "https://doi.org/10.1016/0306-4522(94)90539-8" @default.
• W2055994515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7891855" @default.
• W2055994515 hasPublicationYear "1994" @default.
• W2055994515 type Work @default.
• W2055994515 sameAs 2055994515 @default.
• W2055994515 citedByCount "25" @default.
• W2055994515 countsByYear W20559945152013 @default.
• W2055994515 countsByYear W20559945152015 @default.
• W2055994515 countsByYear W20559945152016 @default.
• W2055994515 countsByYear W20559945152023 @default.
• W2055994515 crossrefType "journal-article" @default.
• W2055994515 hasAuthorship W2055994515A5010768248 @default.
• W2055994515 hasAuthorship W2055994515A5034314111 @default.
• W2055994515 hasAuthorship W2055994515A5053353441 @default.
• W2055994515 hasAuthorship W2055994515A5067628389 @default.
• W2055994515 hasAuthorship W2055994515A5081521018 @default.
• W2055994515 hasAuthorship W2055994515A5091798197 @default.
• W2055994515 hasConcept C126322002 @default.
• W2055994515 hasConcept C134018914 @default.
• W2055994515 hasConcept C137183658 @default.
• W2055994515 hasConcept C151077648 @default.
• W2055994515 hasConcept C170493617 @default.
• W2055994515 hasConcept C185592680 @default.
• W2055994515 hasConcept C2775841634 @default.
• W2055994515 hasConcept C2775864247 @default.
• W2055994515 hasConcept C2780062018 @default.
• W2055994515 hasConcept C2780938664 @default.
• W2055994515 hasConcept C2781063702 @default.
• W2055994515 hasConcept C50156730 @default.
• W2055994515 hasConcept C513476851 @default.
• W2055994515 hasConcept C55493867 @default.
• W2055994515 hasConcept C71924100 @default.
• W2055994515 hasConcept C86803240 @default.
• W2055994515 hasConcept C88016717 @default.
• W2055994515 hasConceptScore W2055994515C126322002 @default.
• W2055994515 hasConceptScore W2055994515C134018914 @default.
• W2055994515 hasConceptScore W2055994515C137183658 @default.
• W2055994515 hasConceptScore W2055994515C151077648 @default.
• W2055994515 hasConceptScore W2055994515C170493617 @default.
• W2055994515 hasConceptScore W2055994515C185592680 @default.
• W2055994515 hasConceptScore W2055994515C2775841634 @default.
• W2055994515 hasConceptScore W2055994515C2775864247 @default.
• W2055994515 hasConceptScore W2055994515C2780062018 @default.
• W2055994515 hasConceptScore W2055994515C2780938664 @default.

• next