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• W2055995105 abstract "The fate of liposomes and the encapsulated drug was studied after topical application on the skin. Lidocaine applied on the forearm of human volunteers produced greater local anaesthetic effect in the liposomal form than in the cream form (p≤ 0.001 after 1h application). Autoradiography demonstrated higher concentration (p≤001) of 14C-lidocaine in the epidermis and dermis of guinea pigs treated with liposome-encapsulated lidocaine as opposed to lidocaine in Dermabase® cream. Electron microscopic observations, using colloidal iron as an electrondense marker, indicated that intact liposomes penetrated into the skin and deposited in the dermis where they acted as a slow release depot system. On the basis of results in the human volunteers and animals, a hypothetical model for liposome-skin interaction is proposed." @default.
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• W2055995105 date "1990-01-01" @default.
• W2055995105 modified "2023-09-27" @default.
• W2055995105 title "Dermal drug delivery by liposome encapsulation: Clinical and electron microscopic studies" @default.
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• W2055995105 doi "https://doi.org/10.3109/02652049009040470" @default.
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