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- W2055995504 abstract "Summary: Serum sickness nephritis was induced in young (3 weeks old) and old (50 weeks old) Fischer rats by immunization with egg albumin, and the age-related clinicopathological differences were analyzed. At least four differences were recognized between the young and old nephritis rats. First, the induced proteinuria was transient in the young group, but persistent in the old group and second, intramembranous electron dense deposits (IMEDD) in the thickened glomerular basement membrane were characteristic in the old group by electron microscopic observation. Third, the peripheral distribution of immune complexes in glomemlus was much more dominant in the young group. Fourth, the accumulation of monocytes was more prominent in the young group. These findings support the following suggestions: (i) in the ageing rats, there may be lowered efficiency of turnover of the extracellular matrix and the decreased ability of the mononuclear phagocyte system function; (ii) these changes may be responsible for the delayed clearance of the immune complexes from the glomerulus, and (iii) the longstanding presence of IMEDD observed in the ageing rats may play a role in persistent proteinuria." @default.
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- W2055995504 date "1997-06-01" @default.
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- W2055995504 title "Age-related modification of serum sickness nephritis in the rat" @default.
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- W2055995504 doi "https://doi.org/10.1111/j.1440-1797.1997.tb00226.x" @default.
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