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- W2055996927 abstract "A transgenic mouse line that expresses Cre recombinase under control of the human thyroid peroxidase (TPO) gene promoter was established. The activity and specificity of the TPO-driven Cre recombinase were examined by using Northern blotting and by crossing with the ROSA26 reporter transgenic mouse line. In the latter mice, Cre-mediated recombination occurred only in the thyrocytes, and recombination commenced around embryonic day 14.5, at the time during thyroid organogenesis when TPO expression begins. This study demonstrates that the TPO-Cre transgenic mouse is a powerful tool to specifically delete loxP-inserted (floxed) genes in thyrocytes and will be of great value in the study of thyrocyte-specific genes during development and/or in adult thyroids. genesis 39:212–216, 2004. © 2004 Wiley-Liss, Inc." @default.
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- W2055996927 date "2004-01-01" @default.
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- W2055996927 title "Thyrocyte-specific expression of Cre recombinase in transgenic mice" @default.
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- W2055996927 doi "https://doi.org/10.1002/gene.20043" @default.
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