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- W2055998380 abstract "1 In the present study the effects of anterior hypothalamic (AHA) lesions and sham-operations were investigated on the endotoxin-induced airway hyperreactivity in guinea-pigs. Unoperated, sham-operated and AHA-lesioned guinea-pigs were injected intraperitoneally with Escherichia coli endotoxin and the airway reactivity tested four days later in isolated tracheal spirals and in spontaneously breathing anaesthetized animals. Control animals were given sterile saline. 2 Sham-operated control animals demonstrated a diminished responsiveness of the tracheal spirals in vitro and of the lung resistance (ΔR1) in vivo to histamine receptor and cholinoceptor-muscarinic agonists as compared to unoperated control animals. 3 AHA-lesioned control animals showed a responsiveness of the respiratory airways in vitro and in vivo between the values of unoperated and sham-operated control animals, suggesting that lesions partially restored the diminished responsiveness. 4 In unoperated and sham-operated guinea-pigs, endotoxin administration induced hyperreactivity of the tracheal spirals and ΔR1 to histamine receptor and cholinoceptor-muscarinic agonists with respect to the control groups. 5 In AHA-lesioned animals, the endotoxin-induced airway hyperreactivity in vitro and in vivo to histamine receptor and cholinoceptor-muscarinic agonists was absent." @default.
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- W2055998380 date "1988-07-01" @default.
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- W2055998380 title "Effects of anterior hypothalamic lesions and sham-operations on bacterial endotoxin-induced non-specific airway hyperreactivity in vivo and in vitro" @default.
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- W2055998380 doi "https://doi.org/10.1111/j.1476-5381.1988.tb11603.x" @default.
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