Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056003706> ?p ?o ?g. }
- W2056003706 endingPage "168" @default.
- W2056003706 startingPage "162" @default.
- W2056003706 abstract "Cholesteryl ester transfer protein (CETP) catalyzes the transfer of cholesteryl ester from high-density lipoprotein (HDL) to apolipoprotein B-containing lipoproteins in exchange for triglyceride, and thereby plays a major role in lipoprotein metabolism. The reciprocal increase in HDL cholesterol (HDL-C) and decrease in low-density lipoprotein cholesterol (LDL-C) associated with CETP deficiency has led to the search for synthetic CETP inhibitors over the past 15 years. Several potent inhibitors have been identified, two of which — JTT-705 and torcetrapib — are undergoing clinical trials. Recent reports that torcetrapib is able to simultaneously raise HDL-C twofold and lower LDL-C by ≤42% has heightened interest in this new class of agents. Upcoming results from Phase III trials of torcetrapib should provide anatomical measurements of atherosclerosis and thus the first assessment of therapeutic benefit." @default.
- W2056003706 created "2016-06-24" @default.
- W2056003706 creator A5059129240 @default.
- W2056003706 date "2006-04-01" @default.
- W2056003706 modified "2023-10-16" @default.
- W2056003706 title "Raising high-density lipoprotein with cholesteryl ester transfer protein inhibitors" @default.
- W2056003706 cites W1552121147 @default.
- W2056003706 cites W1900156693 @default.
- W2056003706 cites W1981003642 @default.
- W2056003706 cites W1982579551 @default.
- W2056003706 cites W1984849143 @default.
- W2056003706 cites W1986389697 @default.
- W2056003706 cites W1990231896 @default.
- W2056003706 cites W1993306998 @default.
- W2056003706 cites W1996959148 @default.
- W2056003706 cites W1999910359 @default.
- W2056003706 cites W2010353571 @default.
- W2056003706 cites W2014137262 @default.
- W2056003706 cites W2017062359 @default.
- W2056003706 cites W2018066700 @default.
- W2056003706 cites W2023813030 @default.
- W2056003706 cites W2026747629 @default.
- W2056003706 cites W2028737910 @default.
- W2056003706 cites W2028859723 @default.
- W2056003706 cites W2031185570 @default.
- W2056003706 cites W2046991199 @default.
- W2056003706 cites W2061334464 @default.
- W2056003706 cites W2074571762 @default.
- W2056003706 cites W2077669460 @default.
- W2056003706 cites W2080001549 @default.
- W2056003706 cites W2083392018 @default.
- W2056003706 cites W2085927073 @default.
- W2056003706 cites W2098509001 @default.
- W2056003706 cites W2099335802 @default.
- W2056003706 cites W2099518239 @default.
- W2056003706 cites W2100632362 @default.
- W2056003706 cites W2101777997 @default.
- W2056003706 cites W2102768269 @default.
- W2056003706 cites W2113561629 @default.
- W2056003706 cites W2117416880 @default.
- W2056003706 cites W2125757745 @default.
- W2056003706 cites W2126816601 @default.
- W2056003706 cites W2131620609 @default.
- W2056003706 cites W2134930063 @default.
- W2056003706 cites W2135631433 @default.
- W2056003706 cites W2137942623 @default.
- W2056003706 cites W2147426030 @default.
- W2056003706 cites W2159449551 @default.
- W2056003706 cites W2159712974 @default.
- W2056003706 cites W2163991584 @default.
- W2056003706 cites W2166033139 @default.
- W2056003706 cites W2167542744 @default.
- W2056003706 cites W2167830505 @default.
- W2056003706 cites W2183402605 @default.
- W2056003706 cites W2282997647 @default.
- W2056003706 cites W2336122760 @default.
- W2056003706 cites W2339504049 @default.
- W2056003706 cites W1925541601 @default.
- W2056003706 cites W752895202 @default.
- W2056003706 doi "https://doi.org/10.1016/j.coph.2005.10.012" @default.
- W2056003706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16487747" @default.
- W2056003706 hasPublicationYear "2006" @default.
- W2056003706 type Work @default.
- W2056003706 sameAs 2056003706 @default.
- W2056003706 citedByCount "23" @default.
- W2056003706 countsByYear W20560037062012 @default.
- W2056003706 countsByYear W20560037062014 @default.
- W2056003706 countsByYear W20560037062016 @default.
- W2056003706 countsByYear W20560037062018 @default.
- W2056003706 crossrefType "journal-article" @default.
- W2056003706 hasAuthorship W2056003706A5059129240 @default.
- W2056003706 hasConcept C110459506 @default.
- W2056003706 hasConcept C126322002 @default.
- W2056003706 hasConcept C134018914 @default.
- W2056003706 hasConcept C185592680 @default.
- W2056003706 hasConcept C2776448209 @default.
- W2056003706 hasConcept C2778163477 @default.
- W2056003706 hasConcept C2778913445 @default.
- W2056003706 hasConcept C2780072125 @default.
- W2056003706 hasConcept C2780541478 @default.
- W2056003706 hasConcept C45505151 @default.
- W2056003706 hasConcept C55493867 @default.
- W2056003706 hasConcept C62746215 @default.
- W2056003706 hasConcept C71924100 @default.
- W2056003706 hasConcept C98274493 @default.
- W2056003706 hasConceptScore W2056003706C110459506 @default.
- W2056003706 hasConceptScore W2056003706C126322002 @default.
- W2056003706 hasConceptScore W2056003706C134018914 @default.
- W2056003706 hasConceptScore W2056003706C185592680 @default.
- W2056003706 hasConceptScore W2056003706C2776448209 @default.
- W2056003706 hasConceptScore W2056003706C2778163477 @default.
- W2056003706 hasConceptScore W2056003706C2778913445 @default.
- W2056003706 hasConceptScore W2056003706C2780072125 @default.
- W2056003706 hasConceptScore W2056003706C2780541478 @default.
- W2056003706 hasConceptScore W2056003706C45505151 @default.
- W2056003706 hasConceptScore W2056003706C55493867 @default.
- W2056003706 hasConceptScore W2056003706C62746215 @default.
- W2056003706 hasConceptScore W2056003706C71924100 @default.