Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056005296> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2056005296 endingPage "1201" @default.
- W2056005296 startingPage "1195" @default.
- W2056005296 abstract "Nitrobenzene is a carcinogen, which induces-among others-thyroid tumors. Melatonin is an effective antioxidant, whereas some antioxidative effects of propylthiouracil (PTU; an antithyroid medication used for the treatment of thyrotoxicosis) were also found. The aim of the study was to compare protective effects of melatonin and PTU against lipid peroxidation in homogenates of porcine thyroids, incubated in the presence of nitrobenzene.Homogenates of porcine thyroids were incubated for 30 min in the presence of nitrobenzene (0.001, 0.01, 0.1, 0.25, 0.5, 1.0, 2.5, 5.0, 7.5, and 10.0 mM). The level of lipid peroxidation products (malondialdehyde + 4-hydroxyalkenals) was measured spectrophotometrically. Nitrobenzene (7.5 and 10.0 mM) increased lipid peroxidation in the homogenates of porcine thyroids. Subsequently, homogenates of porcine thyroids were incubated for 30 min in the presence of nitrobenzene (7.5 mM) plus one of the antioxidants: melatonin (0.000001, 0.00001, 0.0001, 0.001, 0.01, 0.1, 0.25, 0.5, 1.0, 2.5, 5.0, and 7.5 mM) or PTU (0.01, 0.1, 0.25, 0.5, 1.0, 2.5, 5.0, and 7.5 mM).Lipid peroxidation caused by nitrobenzene was effectively prevented by melatonin, with the lowest effective concentration of 0.0001 mM, being only two orders of magnitude higher than physiological blood concentration in humans. At the same time, PTU revealed protective effects only in the highest used concentration (7.5 mM), which is practically never reached during pharmacological treatment in patients with thyrotoxicosis.Melatonin can serve as an effective agent in protection against nitrobenzene-induced lipid peroxidation in porcine thyroid." @default.
- W2056005296 created "2016-06-24" @default.
- W2056005296 creator A5021463387 @default.
- W2056005296 creator A5048119650 @default.
- W2056005296 date "2013-05-30" @default.
- W2056005296 modified "2023-09-25" @default.
- W2056005296 title "Comparison of potential protective effects of melatonin and propylthiouracil against lipid peroxidation caused by nitrobenzene in the thyroid gland" @default.
- W2056005296 cites W1971424572 @default.
- W2056005296 cites W1972259716 @default.
- W2056005296 cites W1977264349 @default.
- W2056005296 cites W1979297298 @default.
- W2056005296 cites W1980217167 @default.
- W2056005296 cites W1988004297 @default.
- W2056005296 cites W1993435271 @default.
- W2056005296 cites W1993458321 @default.
- W2056005296 cites W1994557576 @default.
- W2056005296 cites W2002989122 @default.
- W2056005296 cites W2031580464 @default.
- W2056005296 cites W2043572832 @default.
- W2056005296 cites W2065949164 @default.
- W2056005296 cites W2089176851 @default.
- W2056005296 cites W2092441095 @default.
- W2056005296 cites W2093430162 @default.
- W2056005296 cites W2095189712 @default.
- W2056005296 cites W2099000346 @default.
- W2056005296 cites W2122220769 @default.
- W2056005296 cites W2134118673 @default.
- W2056005296 cites W2149134901 @default.
- W2056005296 cites W2149803624 @default.
- W2056005296 cites W2153446574 @default.
- W2056005296 cites W349338294 @default.
- W2056005296 cites W4293247451 @default.
- W2056005296 doi "https://doi.org/10.1177/0748233713491799" @default.
- W2056005296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23723263" @default.
- W2056005296 hasPublicationYear "2013" @default.
- W2056005296 type Work @default.
- W2056005296 sameAs 2056005296 @default.
- W2056005296 citedByCount "6" @default.
- W2056005296 countsByYear W20560052962016 @default.
- W2056005296 countsByYear W20560052962018 @default.
- W2056005296 countsByYear W20560052962019 @default.
- W2056005296 countsByYear W20560052962021 @default.
- W2056005296 countsByYear W20560052962022 @default.
- W2056005296 crossrefType "journal-article" @default.
- W2056005296 hasAuthorship W2056005296A5021463387 @default.
- W2056005296 hasAuthorship W2056005296A5048119650 @default.
- W2056005296 hasConcept C126322002 @default.
- W2056005296 hasConcept C134018914 @default.
- W2056005296 hasConcept C161790260 @default.
- W2056005296 hasConcept C185592680 @default.
- W2056005296 hasConcept C2775960720 @default.
- W2056005296 hasConcept C2776830370 @default.
- W2056005296 hasConcept C2778004101 @default.
- W2056005296 hasConcept C2778182776 @default.
- W2056005296 hasConcept C2778401633 @default.
- W2056005296 hasConcept C2780809723 @default.
- W2056005296 hasConcept C2780829032 @default.
- W2056005296 hasConcept C526584372 @default.
- W2056005296 hasConcept C55493867 @default.
- W2056005296 hasConcept C71924100 @default.
- W2056005296 hasConcept C98274493 @default.
- W2056005296 hasConceptScore W2056005296C126322002 @default.
- W2056005296 hasConceptScore W2056005296C134018914 @default.
- W2056005296 hasConceptScore W2056005296C161790260 @default.
- W2056005296 hasConceptScore W2056005296C185592680 @default.
- W2056005296 hasConceptScore W2056005296C2775960720 @default.
- W2056005296 hasConceptScore W2056005296C2776830370 @default.
- W2056005296 hasConceptScore W2056005296C2778004101 @default.
- W2056005296 hasConceptScore W2056005296C2778182776 @default.
- W2056005296 hasConceptScore W2056005296C2778401633 @default.
- W2056005296 hasConceptScore W2056005296C2780809723 @default.
- W2056005296 hasConceptScore W2056005296C2780829032 @default.
- W2056005296 hasConceptScore W2056005296C526584372 @default.
- W2056005296 hasConceptScore W2056005296C55493867 @default.
- W2056005296 hasConceptScore W2056005296C71924100 @default.
- W2056005296 hasConceptScore W2056005296C98274493 @default.
- W2056005296 hasIssue "12" @default.
- W2056005296 hasLocation W20560052961 @default.
- W2056005296 hasLocation W20560052962 @default.
- W2056005296 hasOpenAccess W2056005296 @default.
- W2056005296 hasPrimaryLocation W20560052961 @default.
- W2056005296 hasRelatedWork W1986172466 @default.
- W2056005296 hasRelatedWork W1991606870 @default.
- W2056005296 hasRelatedWork W2011960454 @default.
- W2056005296 hasRelatedWork W2069765647 @default.
- W2056005296 hasRelatedWork W2074577918 @default.
- W2056005296 hasRelatedWork W2100004854 @default.
- W2056005296 hasRelatedWork W2123541238 @default.
- W2056005296 hasRelatedWork W2135172604 @default.
- W2056005296 hasRelatedWork W2155302289 @default.
- W2056005296 hasRelatedWork W4300647150 @default.
- W2056005296 hasVolume "31" @default.
- W2056005296 isParatext "false" @default.
- W2056005296 isRetracted "false" @default.
- W2056005296 magId "2056005296" @default.
- W2056005296 workType "article" @default.