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- W2056007468 abstract "Cyclophosphamide in a dose of 1.8 mg. per mouse per week given continuously from 120, 160, or 200 days of age decreased the incidence of severe renal disease from 100% to 6.7% in female B/W mice. Cessation of therapy at 1 year of age was not associated with an increase in the incidence of renal disease. Mice given long-term treatment lived nearly twice as long as untreated mice. Short courses of cyclophosphamide in a dose of 5 mg. per mouse per week for 4 weeks also resulted in longevity, although the effect was not as marked as with long-term treatment. The incidence of kidney disease was reduced to about half that in untreated mice. These very striking results suggest that cyclophosphamide may have an important role in the treatment of autoimmune disease in man." @default.
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- W2056007468 date "1968-03-01" @default.
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- W2056007468 title "CYCLOPHOSPHAMIDE TREATMENT OF RENAL DISEASE IN (NZB × NZW) F1 HYBRID MICE" @default.
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- W2056007468 doi "https://doi.org/10.1016/s0140-6736(68)92778-5" @default.
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