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- W2056017011 endingPage "e1004130" @default.
- W2056017011 startingPage "e1004130" @default.
- W2056017011 abstract "Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment. Cells of the neural crest employ multiple signaling mechanisms to control migration and differentiation during development. It is known that defects in these mechanisms cause neuroblastoma, but how multiple signaling pathways interact to govern cell behavior is unknown. In a phosphoproteomic study of neuroblastoma cell lines and cell fractions, including endosomes and detergent-resistant membranes, 1622 phosphorylated proteins were detected, including more than half of the receptor tyrosine kinases in the human genome. Data were analyzed using a combination of graph theory and pattern recognition techniques that resolve data structure into networks that incorporate statistical relationships and protein-protein interaction data. Clusters of proteins in these networks are indicative of functional signaling pathways. The analysis indicates that receptor tyrosine kinases are functionally compartmentalized into distinct collaborative groups distinguished by activation and intracellular localization of SRC-family kinases, especially FYN and LYN. Changes in intracellular localization of activated FYN and LYN were observed in response to stimulation of the receptor tyrosine kinases, ALK and KIT. The results suggest a mechanism to distinguish signaling responses to activation of different receptors, or combinations of receptors, that govern the behavior of the neural crest, which gives rise to neuroblastoma." @default.
- W2056017011 created "2016-06-24" @default.
- W2056017011 creator A5010668546 @default.
- W2056017011 creator A5013131951 @default.
- W2056017011 creator A5028493935 @default.
- W2056017011 creator A5031590332 @default.
- W2056017011 creator A5042973348 @default.
- W2056017011 creator A5076089901 @default.
- W2056017011 creator A5081230626 @default.
- W2056017011 creator A5087300609 @default.
- W2056017011 date "2015-04-17" @default.
- W2056017011 modified "2023-10-10" @default.
- W2056017011 title "Neuroblastoma Tyrosine Kinase Signaling Networks Involve FYN and LYN in Endosomes and Lipid Rafts" @default.
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