FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056021978> ?p ?o ?g. }

• W2056021978 endingPage "1188" @default.
• W2056021978 startingPage "1181" @default.
• W2056021978 abstract "The objective of this study was to determine how different techniques used during the freezing step of lyophilization affect morphology of the dried protein solids. Aqueous solutions containing recombinant human albumin, trehalose, and sodium phosphate buffer were dried after their freezing by shelf-ramp cooling, immersion in liquid nitrogen, or controlled ice nucleation. Some shelf-frozen solutions were heat treated (annealed) before the vacuum drying. We used three-dimensional (3D) X-ray micro-computed tomography (micro-CT) and scanning electron microscopy (SEM) to study the morphology of solids. The X-ray micro-CT images of the lyophilized microporous solids showed traces of varied size and structure ice crystals that were comparable to corresponding SEM images. A post-freeze heat treatment and a controlled nucleation both induced larger ice crystal ghosts in the solids. The variations in the structure of walls surrounding ice crystals, formed by the different freezing procedures, should affect the water vapor transition during the primary and secondary drying. Some solids also showed higher-density layer in the upper surface. Overall, the simple sample preparation procedures and the ample morphological information make the X-ray micro-CT appropriate for analyzing lyophilized pharmaceuticals." @default.
• W2056021978 created "2016-06-24" @default.
• W2056021978 creator A5046241182 @default.
• W2056021978 creator A5053797637 @default.
• W2056021978 creator A5076370249 @default.
• W2056021978 creator A5077706331 @default.
• W2056021978 creator A5084950208 @default.
• W2056021978 date "2014-05-31" @default.
• W2056021978 modified "2023-10-05" @default.
• W2056021978 title "Studying the Morphology of Lyophilized Protein Solids Using X-ray Micro-CT: Effect of Post-freeze Annealing and Controlled Nucleation" @default.
• W2056021978 cites W139461521 @default.
• W2056021978 cites W1530937340 @default.
• W2056021978 cites W1539518693 @default.
• W2056021978 cites W1574355027 @default.
• W2056021978 cites W1977805806 @default.
• W2056021978 cites W1992643499 @default.
• W2056021978 cites W2003335161 @default.
• W2056021978 cites W2008670507 @default.
• W2056021978 cites W2018214909 @default.
• W2056021978 cites W2022341494 @default.
• W2056021978 cites W2024813115 @default.
• W2056021978 cites W2028883025 @default.
• W2056021978 cites W2043552747 @default.
• W2056021978 cites W2048199422 @default.
• W2056021978 cites W2054956418 @default.
• W2056021978 cites W2055127900 @default.
• W2056021978 cites W2063379910 @default.
• W2056021978 cites W2067717338 @default.
• W2056021978 cites W2069142699 @default.
• W2056021978 cites W2072882720 @default.
• W2056021978 cites W2073369002 @default.
• W2056021978 cites W2074061140 @default.
• W2056021978 cites W2078221639 @default.
• W2056021978 cites W2083236922 @default.
• W2056021978 cites W2087427868 @default.
• W2056021978 cites W2096006175 @default.
• W2056021978 cites W2101881985 @default.
• W2056021978 cites W2102259095 @default.
• W2056021978 cites W2130816910 @default.
• W2056021978 cites W2144462299 @default.
• W2056021978 cites W2155948495 @default.
• W2056021978 cites W2159640426 @default.
• W2056021978 doi "https://doi.org/10.1208/s12249-014-0152-5" @default.
• W2056021978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4179649" @default.
• W2056021978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24879291" @default.
• W2056021978 hasPublicationYear "2014" @default.
• W2056021978 type Work @default.
• W2056021978 sameAs 2056021978 @default.
• W2056021978 citedByCount "17" @default.
• W2056021978 countsByYear W20560219782015 @default.
• W2056021978 countsByYear W20560219782016 @default.
• W2056021978 countsByYear W20560219782018 @default.
• W2056021978 countsByYear W20560219782020 @default.
• W2056021978 countsByYear W20560219782021 @default.
• W2056021978 countsByYear W20560219782023 @default.
• W2056021978 crossrefType "journal-article" @default.
• W2056021978 hasAuthorship W2056021978A5046241182 @default.
• W2056021978 hasAuthorship W2056021978A5053797637 @default.
• W2056021978 hasAuthorship W2056021978A5076370249 @default.
• W2056021978 hasAuthorship W2056021978A5077706331 @default.
• W2056021978 hasAuthorship W2056021978A5084950208 @default.
• W2056021978 hasBestOaLocation W20560219782 @default.
• W2056021978 hasConcept C108939769 @default.
• W2056021978 hasConcept C120665830 @default.
• W2056021978 hasConcept C121332964 @default.
• W2056021978 hasConcept C122409099 @default.
• W2056021978 hasConcept C125388846 @default.
• W2056021978 hasConcept C127413603 @default.
• W2056021978 hasConcept C159985019 @default.
• W2056021978 hasConcept C178790620 @default.
• W2056021978 hasConcept C185592680 @default.
• W2056021978 hasConcept C192562407 @default.
• W2056021978 hasConcept C199289684 @default.
• W2056021978 hasConcept C26771246 @default.
• W2056021978 hasConcept C2777855556 @default.
• W2056021978 hasConcept C39519442 @default.
• W2056021978 hasConcept C42360764 @default.
• W2056021978 hasConcept C43617362 @default.
• W2056021978 hasConcept C61048295 @default.
• W2056021978 hasConcept C8010536 @default.
• W2056021978 hasConcept C84199377 @default.
• W2056021978 hasConcept C86381522 @default.
• W2056021978 hasConcept C97355855 @default.
• W2056021978 hasConceptScore W2056021978C108939769 @default.
• W2056021978 hasConceptScore W2056021978C120665830 @default.
• W2056021978 hasConceptScore W2056021978C121332964 @default.
• W2056021978 hasConceptScore W2056021978C122409099 @default.
• W2056021978 hasConceptScore W2056021978C125388846 @default.
• W2056021978 hasConceptScore W2056021978C127413603 @default.
• W2056021978 hasConceptScore W2056021978C159985019 @default.
• W2056021978 hasConceptScore W2056021978C178790620 @default.
• W2056021978 hasConceptScore W2056021978C185592680 @default.
• W2056021978 hasConceptScore W2056021978C192562407 @default.
• W2056021978 hasConceptScore W2056021978C199289684 @default.
• W2056021978 hasConceptScore W2056021978C26771246 @default.
• W2056021978 hasConceptScore W2056021978C2777855556 @default.
• W2056021978 hasConceptScore W2056021978C39519442 @default.
• W2056021978 hasConceptScore W2056021978C42360764 @default.

• next