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- W2056023812 endingPage "631" @default.
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- W2056023812 abstract "For treatment of benign nodular goitre the choice usually stands between surgery and (131)I therapy. (131)I therapy, used for 30 years for this condition, leads to a goitre volume reduction of 35-50% within 1-2 years. However, this treatment has limited efficacy if the thyroid (131)I uptake is low or if the goitre is large. Recombinant human TSH (rhTSH)-stimulated (131)I therapy significantly improves goitre reduction, as compared with conventional (131)I therapy without pre-stimulation, and adverse effects are few with rhTSH doses of 0.1 mg or lower. RhTSH-stimulated (131)I therapy reduces the need for additional therapy due to insufficient goitre reduction, but the price is a higher rate of hypothyroidism. Another approach with rhTSH-stimulation is to reduce the administered (131)I activity by a factor that equals the increase in the thyroid (131)I uptake. Using this approach, radiation exposure is considerably reduced while the goitre reduction is similar to that obtained with conventional (131)I therapy." @default.
- W2056023812 created "2016-06-24" @default.
- W2056023812 creator A5039528393 @default.
- W2056023812 creator A5047956868 @default.
- W2056023812 creator A5072144010 @default.
- W2056023812 date "2014-08-01" @default.
- W2056023812 modified "2023-10-18" @default.
- W2056023812 title "The role of radioiodine therapy in benign nodular goitre" @default.
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- W2056023812 doi "https://doi.org/10.1016/j.beem.2014.02.001" @default.
- W2056023812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25047210" @default.
- W2056023812 hasPublicationYear "2014" @default.