FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056025023> ?p ?o ?g. }

• W2056025023 endingPage "1286" @default.
• W2056025023 startingPage "1279" @default.
• W2056025023 abstract "The number and function of myeloid cells in the lungs are critical determinants of health and disease. To examine whether these cells can be modulated in vivo by a colony-stimulating factor (CSF), recombinant human granulocyte macrophage-CSF (GM-CSF) was given to cynomolgus monkeys by either continuous intravenous infusion (7,200 U/kg/day) for 2 wk or by aerosol exposure to 107 U on 1 or 2 consecutive days. At intervals after the initiation of GM-CSF administration, animals underwent bronchoalveolar lavage (BAL) and had peripheral blood sampled to characterize changes in lung and circulating phagocytic cells. Compared with animals exposed to bovine serum albumin, there was an increase in the total number of BAL cells retrieved. This increase was greatest in animals receiving aerosolized GM-CSF, and it was the result of more macrophages and neutrophils. Both lung macrophages and blood neutrophils from animals exposed to aerosolized GM-CSF exhibited an augmented respiratory burst in response to phorbol myristate acetate. Lung macrophages from GM-CSF-exposed animals exhibited increased capacity to bind and/or ingest opsonized and unopsonized Staphylococcus aureus. Despite functional activation of lung phagocytic cells, biochemical analyses of BAL fluid for markers of lung injury revealed an increase in only some parameters in the GM-CSF group. Intravenous administration of GM-CSF had the expected effect on augmenting the number of myeloid cells in the bloodstream. Aerosolized GM-CSF produced a transient effect on circulating myeloid cell number between 3 and 5 days after exposure. These studies demonstrated that exogenous GM-CSF is capable of increasing the number and function of phagocytic cells in the lungs in addition to the peripheral blood compartment, and they suggest an important role for this cytokine in lung biology." @default.
• W2056025023 created "2016-06-24" @default.
• W2056025023 creator A5005130436 @default.
• W2056025023 creator A5012656746 @default.
• W2056025023 creator A5015806924 @default.
• W2056025023 creator A5016843919 @default.
• W2056025023 creator A5018590586 @default.
• W2056025023 creator A5042909091 @default.
• W2056025023 creator A5050022583 @default.
• W2056025023 creator A5052878737 @default.
• W2056025023 creator A5053745639 @default.
• W2056025023 creator A5085670515 @default.
• W2056025023 date "1992-11-01" @default.
• W2056025023 modified "2023-09-26" @default.
• W2056025023 title "The Effect of Aerosolized Recombinant Human Granulocyte Macrophage Colony-stimulating Factor on Lung Leukocytes in Nonhuman Primates" @default.
• W2056025023 cites W1587557698 @default.
• W2056025023 cites W1967643308 @default.
• W2056025023 cites W1977157092 @default.
• W2056025023 cites W1980601390 @default.
• W2056025023 cites W1990372115 @default.
• W2056025023 cites W2017013844 @default.
• W2056025023 cites W2108006679 @default.
• W2056025023 cites W2114242966 @default.
• W2056025023 cites W2130950961 @default.
• W2056025023 cites W2161436620 @default.
• W2056025023 cites W2320667912 @default.
• W2056025023 cites W4244591305 @default.
• W2056025023 doi "https://doi.org/10.1164/ajrccm/146.5_pt_1.1279" @default.
• W2056025023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1443885" @default.
• W2056025023 hasPublicationYear "1992" @default.
• W2056025023 type Work @default.
• W2056025023 sameAs 2056025023 @default.
• W2056025023 citedByCount "24" @default.
• W2056025023 countsByYear W20560250232012 @default.
• W2056025023 countsByYear W20560250232013 @default.
• W2056025023 countsByYear W20560250232015 @default.
• W2056025023 countsByYear W20560250232018 @default.
• W2056025023 countsByYear W20560250232020 @default.
• W2056025023 crossrefType "journal-article" @default.
• W2056025023 hasAuthorship W2056025023A5005130436 @default.
• W2056025023 hasAuthorship W2056025023A5012656746 @default.
• W2056025023 hasAuthorship W2056025023A5015806924 @default.
• W2056025023 hasAuthorship W2056025023A5016843919 @default.
• W2056025023 hasAuthorship W2056025023A5018590586 @default.
• W2056025023 hasAuthorship W2056025023A5042909091 @default.
• W2056025023 hasAuthorship W2056025023A5050022583 @default.
• W2056025023 hasAuthorship W2056025023A5052878737 @default.
• W2056025023 hasAuthorship W2056025023A5053745639 @default.
• W2056025023 hasAuthorship W2056025023A5085670515 @default.
• W2056025023 hasConcept C109159458 @default.
• W2056025023 hasConcept C126322002 @default.
• W2056025023 hasConcept C160448771 @default.
• W2056025023 hasConcept C202751555 @default.
• W2056025023 hasConcept C203014093 @default.
• W2056025023 hasConcept C2777478134 @default.
• W2056025023 hasConcept C2777714996 @default.
• W2056025023 hasConcept C2777961210 @default.
• W2056025023 hasConcept C2777983669 @default.
• W2056025023 hasConcept C2778690821 @default.
• W2056025023 hasConcept C2779244956 @default.
• W2056025023 hasConcept C2779282312 @default.
• W2056025023 hasConcept C2781184567 @default.
• W2056025023 hasConcept C28328180 @default.
• W2056025023 hasConcept C54355233 @default.
• W2056025023 hasConcept C55493867 @default.
• W2056025023 hasConcept C71924100 @default.
• W2056025023 hasConcept C86803240 @default.
• W2056025023 hasConcept C880424 @default.
• W2056025023 hasConcept C99971728 @default.
• W2056025023 hasConceptScore W2056025023C109159458 @default.
• W2056025023 hasConceptScore W2056025023C126322002 @default.
• W2056025023 hasConceptScore W2056025023C160448771 @default.
• W2056025023 hasConceptScore W2056025023C202751555 @default.
• W2056025023 hasConceptScore W2056025023C203014093 @default.
• W2056025023 hasConceptScore W2056025023C2777478134 @default.
• W2056025023 hasConceptScore W2056025023C2777714996 @default.
• W2056025023 hasConceptScore W2056025023C2777961210 @default.
• W2056025023 hasConceptScore W2056025023C2777983669 @default.
• W2056025023 hasConceptScore W2056025023C2778690821 @default.
• W2056025023 hasConceptScore W2056025023C2779244956 @default.
• W2056025023 hasConceptScore W2056025023C2779282312 @default.
• W2056025023 hasConceptScore W2056025023C2781184567 @default.
• W2056025023 hasConceptScore W2056025023C28328180 @default.
• W2056025023 hasConceptScore W2056025023C54355233 @default.
• W2056025023 hasConceptScore W2056025023C55493867 @default.
• W2056025023 hasConceptScore W2056025023C71924100 @default.
• W2056025023 hasConceptScore W2056025023C86803240 @default.
• W2056025023 hasConceptScore W2056025023C880424 @default.
• W2056025023 hasConceptScore W2056025023C99971728 @default.
• W2056025023 hasIssue "5_pt_1" @default.
• W2056025023 hasLocation W20560250231 @default.
• W2056025023 hasLocation W20560250232 @default.
• W2056025023 hasOpenAccess W2056025023 @default.
• W2056025023 hasPrimaryLocation W20560250231 @default.
• W2056025023 hasRelatedWork W1552448276 @default.
• W2056025023 hasRelatedWork W1605376961 @default.
• W2056025023 hasRelatedWork W2031356164 @default.
• W2056025023 hasRelatedWork W2088940635 @default.

• next