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- W2056034283 abstract "Corneal transplantation is a sight-restorative procedure but its success is limited by irreversible graft rejection, which accounts for up to 50 per cent of failures. The normal eye is an immune-privileged site. Multiple mechanisms maintain ocular privilege, including the blood-eye barrier, the lack of blood vessels and lymphatics in the normal cornea, the relative paucity of mature antigen-presenting cells in the central cornea, the presence of immunomodulatory factors in ocular fluids, and the constitutive expressive of CD95L (Fas ligand) within the eye. However, privilege can be eroded by the sequelae of inflammation and neovascularization. Corneal graft rejection in humans is currently suppressed with topical glucocorticosteroids, which are moderately effective. Systemically administered immunosuppressive therapy is of limited efficacy and may be accompanied by unacceptable morbidity. Alternative therapies are needed to improve outcomes. Corneal graft rejection is primarily a cell-mediated response controlled by the CD4+ T cell, and thus CD4 and costimulatory molecule blockade are appealing targets for new therapeutic interventions. A number of monoclonal antibodies have shown promise as immunosuppressants to prolong corneal graft survival in experimental animal models, and may eventually prove to be useful adjuncts to corticosteroids." @default.
- W2056034283 created "2016-06-24" @default.
- W2056034283 creator A5012247167 @default.
- W2056034283 creator A5022956666 @default.
- W2056034283 creator A5065849932 @default.
- W2056034283 date "2003-04-01" @default.
- W2056034283 modified "2023-10-05" @default.
- W2056034283 title "The potential of antibody‐based immunosuppressive agents for corneal transplantation" @default.
- W2056034283 cites W117356842 @default.
- W2056034283 cites W1493257440 @default.
- W2056034283 cites W1507999061 @default.
- W2056034283 cites W1534379527 @default.
- W2056034283 cites W1537910985 @default.
- W2056034283 cites W1544663570 @default.
- W2056034283 cites W1581871973 @default.
- W2056034283 cites W1589529996 @default.
- W2056034283 cites W1605187674 @default.
- W2056034283 cites W1709882622 @default.
- W2056034283 cites W1964180179 @default.
- W2056034283 cites W1964689373 @default.
- W2056034283 cites W1966375571 @default.
- W2056034283 cites W1966762401 @default.
- W2056034283 cites W1966809245 @default.
- W2056034283 cites W1967515564 @default.
- W2056034283 cites W1971006475 @default.
- W2056034283 cites W1974062666 @default.
- W2056034283 cites W1974074261 @default.
- W2056034283 cites W1974231754 @default.
- W2056034283 cites W1974989317 @default.
- W2056034283 cites W1975220496 @default.
- W2056034283 cites W1975807860 @default.
- W2056034283 cites W1976755778 @default.
- W2056034283 cites W1978018492 @default.
- W2056034283 cites W1978321168 @default.
- W2056034283 cites W1978576791 @default.
- W2056034283 cites W1980344676 @default.
- W2056034283 cites W1980998190 @default.
- W2056034283 cites W1982387683 @default.
- W2056034283 cites W1982683234 @default.
- W2056034283 cites W1982944258 @default.
- W2056034283 cites W1983633004 @default.
- W2056034283 cites W1983812042 @default.
- W2056034283 cites W1984160754 @default.
- W2056034283 cites W1984930430 @default.
- W2056034283 cites W1985272222 @default.
- W2056034283 cites W1985683892 @default.
- W2056034283 cites W1986823457 @default.
- W2056034283 cites W1989400519 @default.
- W2056034283 cites W1996038495 @default.
- W2056034283 cites W1996473489 @default.
- W2056034283 cites W1996853317 @default.
- W2056034283 cites W1997208457 @default.
- W2056034283 cites W1997721316 @default.
- W2056034283 cites W1998248270 @default.
- W2056034283 cites W1998944080 @default.
- W2056034283 cites W2000620661 @default.
- W2056034283 cites W2004831329 @default.
- W2056034283 cites W2004882711 @default.
- W2056034283 cites W2005007838 @default.
- W2056034283 cites W2007466915 @default.
- W2056034283 cites W2007524673 @default.
- W2056034283 cites W2008049771 @default.
- W2056034283 cites W2014159878 @default.
- W2056034283 cites W2014452295 @default.
- W2056034283 cites W2015417888 @default.
- W2056034283 cites W2018474956 @default.
- W2056034283 cites W2019620441 @default.
- W2056034283 cites W2019800569 @default.
- W2056034283 cites W2020468743 @default.
- W2056034283 cites W2020669743 @default.
- W2056034283 cites W2020801013 @default.
- W2056034283 cites W2020991873 @default.
- W2056034283 cites W2021889177 @default.
- W2056034283 cites W2022724873 @default.
- W2056034283 cites W2023449507 @default.
- W2056034283 cites W2026856587 @default.
- W2056034283 cites W2029127198 @default.
- W2056034283 cites W2030517742 @default.
- W2056034283 cites W2031599341 @default.
- W2056034283 cites W2034551457 @default.
- W2056034283 cites W2038008461 @default.
- W2056034283 cites W2042630557 @default.
- W2056034283 cites W2042786879 @default.
- W2056034283 cites W2042932969 @default.
- W2056034283 cites W2043640719 @default.
- W2056034283 cites W2045149593 @default.
- W2056034283 cites W2045390721 @default.
- W2056034283 cites W2045591714 @default.
- W2056034283 cites W2046118526 @default.
- W2056034283 cites W2046397066 @default.
- W2056034283 cites W2046806013 @default.
- W2056034283 cites W2048320264 @default.
- W2056034283 cites W2051002890 @default.
- W2056034283 cites W2052892764 @default.
- W2056034283 cites W2056109074 @default.
- W2056034283 cites W2058002627 @default.
- W2056034283 cites W2059846081 @default.
- W2056034283 cites W2060820237 @default.