FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056041311> ?p ?o ?g. }

• W2056041311 endingPage "75" @default.
• W2056041311 startingPage "67" @default.
• W2056041311 abstract "1 The cardiovascular effects of centrally administered 5-hydroxytryptamine (5-HT) have been analysed in conscious normotensive and hypertensive rats. 2 In conscious normotensive rats, 5-HT, (1–30 μg) administered intracerebroventricularly (i.c.v.) produced profound and immediate dose-related decreases in heart rate and small increases in blood pressure. The initial pressor responses were followed by secondary secondary depressor responses at high doses of 5-HT. 3 Similar effects were produced by 5-HT i.c.v. in conscious DOCA-salt and spontaneously hypertensive rats, although the magnitude of the pressor responses was substantially greater in hypertensive than normotensive rats. 4 Pretreatment with either N-methylatropine or atenolol intra-arterially reduced the 5-HT-induced bradycardia in normotensive rats; the reduction was enhanced when both antagonists were given in combination. 5 The 5-HT2 antagonist, cyproheptadine (10 μg i.c.v.) increased basal blood pressure and heart rate in normotensive rats. Subsequent administration of 5-HT i.c.v. produced biphasic effects on heart rate consisting of an initial tachycardia followed by a marked bradycardia. 6 Methysergide (10 μg i.c.v.) pretreatment did not alter resting heart rate, but attenuated the 5-HT induced bradycardia. A higher dose of methysergide, (30 μg i.c.v.), decreased resting blood pressure and heart rate. 7 This study has demonstrated, therefore, that the 5-HT induced bradycardia is produced by not only a centrally mediated decrease in sympathetic tone, but also an increase in vagal drive to the heart. The bradycardia is antagonised by centrally administered methysergide, but not by cyproheptadine, which suggests that it is probably mediated through a ‘5-HT1-like’ receptor mechanism." @default.
• W2056041311 created "2016-06-24" @default.
• W2056041311 creator A5077859935 @default.
• W2056041311 date "1986-03-01" @default.
• W2056041311 modified "2023-10-18" @default.
• W2056041311 title "THE CARDIOVASCULAR EFFECTS OF CENTRALLY ADMINISTERED 5-HYDROXYTRYPTAMINE IN THE CONSCIOUS NORMOTENSIVE AND HYPERTENSIVE RAT" @default.
• W2056041311 cites W1965295312 @default.
• W2056041311 cites W1966365853 @default.
• W2056041311 cites W1972712399 @default.
• W2056041311 cites W1977594222 @default.
• W2056041311 cites W1978142623 @default.
• W2056041311 cites W1980367613 @default.
• W2056041311 cites W1980488929 @default.
• W2056041311 cites W1982092023 @default.
• W2056041311 cites W1983304617 @default.
• W2056041311 cites W1996657334 @default.
• W2056041311 cites W1998530877 @default.
• W2056041311 cites W2003033259 @default.
• W2056041311 cites W2011044936 @default.
• W2056041311 cites W2030968187 @default.
• W2056041311 cites W2037116985 @default.
• W2056041311 cites W2062264141 @default.
• W2056041311 cites W2064418473 @default.
• W2056041311 cites W2065678427 @default.
• W2056041311 cites W2066888608 @default.
• W2056041311 cites W2081346316 @default.
• W2056041311 cites W2083298415 @default.
• W2056041311 cites W2085757025 @default.
• W2056041311 cites W2088623374 @default.
• W2056041311 cites W2093271345 @default.
• W2056041311 cites W2094428214 @default.
• W2056041311 cites W2112916622 @default.
• W2056041311 cites W2140285237 @default.
• W2056041311 cites W2175839910 @default.
• W2056041311 cites W2256578783 @default.
• W2056041311 cites W2586182948 @default.
• W2056041311 cites W2601891517 @default.
• W2056041311 doi "https://doi.org/10.1111/j.1474-8673.1986.tb00632.x" @default.
• W2056041311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3957952" @default.
• W2056041311 hasPublicationYear "1986" @default.
• W2056041311 type Work @default.
• W2056041311 sameAs 2056041311 @default.
• W2056041311 citedByCount "24" @default.
• W2056041311 countsByYear W20560413112014 @default.
• W2056041311 countsByYear W20560413112019 @default.
• W2056041311 countsByYear W20560413112020 @default.
• W2056041311 crossrefType "journal-article" @default.
• W2056041311 hasAuthorship W2056041311A5077859935 @default.
• W2056041311 hasConcept C126322002 @default.
• W2056041311 hasConcept C134018914 @default.
• W2056041311 hasConcept C170493617 @default.
• W2056041311 hasConcept C2776525901 @default.
• W2056041311 hasConcept C2776885963 @default.
• W2056041311 hasConcept C2777495988 @default.
• W2056041311 hasConcept C2777953023 @default.
• W2056041311 hasConcept C2778151854 @default.
• W2056041311 hasConcept C2780283014 @default.
• W2056041311 hasConcept C2781005078 @default.
• W2056041311 hasConcept C42219234 @default.
• W2056041311 hasConcept C71924100 @default.
• W2056041311 hasConcept C84393581 @default.
• W2056041311 hasConceptScore W2056041311C126322002 @default.
• W2056041311 hasConceptScore W2056041311C134018914 @default.
• W2056041311 hasConceptScore W2056041311C170493617 @default.
• W2056041311 hasConceptScore W2056041311C2776525901 @default.
• W2056041311 hasConceptScore W2056041311C2776885963 @default.
• W2056041311 hasConceptScore W2056041311C2777495988 @default.
• W2056041311 hasConceptScore W2056041311C2777953023 @default.
• W2056041311 hasConceptScore W2056041311C2778151854 @default.
• W2056041311 hasConceptScore W2056041311C2780283014 @default.
• W2056041311 hasConceptScore W2056041311C2781005078 @default.
• W2056041311 hasConceptScore W2056041311C42219234 @default.
• W2056041311 hasConceptScore W2056041311C71924100 @default.
• W2056041311 hasConceptScore W2056041311C84393581 @default.
• W2056041311 hasIssue "1" @default.
• W2056041311 hasLocation W20560413111 @default.
• W2056041311 hasLocation W20560413112 @default.
• W2056041311 hasOpenAccess W2056041311 @default.
• W2056041311 hasPrimaryLocation W20560413111 @default.
• W2056041311 hasRelatedWork W2004963932 @default.
• W2056041311 hasRelatedWork W2026085455 @default.
• W2056041311 hasRelatedWork W2028507867 @default.
• W2056041311 hasRelatedWork W2048122535 @default.
• W2056041311 hasRelatedWork W2142453885 @default.
• W2056041311 hasRelatedWork W2187253742 @default.
• W2056041311 hasRelatedWork W2394584325 @default.
• W2056041311 hasRelatedWork W2415703681 @default.
• W2056041311 hasRelatedWork W2426183805 @default.
• W2056041311 hasRelatedWork W2428084034 @default.
• W2056041311 hasVolume "6" @default.
• W2056041311 isParatext "false" @default.
• W2056041311 isRetracted "false" @default.
• W2056041311 magId "2056041311" @default.
• W2056041311 workType "article" @default.