FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056051671> ?p ?o ?g. }

• W2056051671 endingPage "153" @default.
• W2056051671 startingPage "137" @default.
• W2056051671 abstract "Adrenergic arousal reactions have been shown to occur by behavioural responses as well as by changes in the electroencephalogram due to stimulation of the ascending sensory receptors in the reticular activating system There is good evidence that the arousal response is not due to the vasopressor action of epinephrine, although clinical observations with most vasopressor drugs point to such an explanation Local vascular changes in the brain which are not necessarily reflected in the general circulation have been suggested and demonstrated as a likely explanation for psychomotor activation by epinephrine The precursors of epinephrine also seem to play a role in the control of alertness and motor functions The negative aspect of this idea explains in part the decrease in spontaneous activity and depression of psychomotor activity in response to reserpine administration The question of whether or not phenylalanine derivatives can themselves produce awakening reactions has been studied to a limited extent A very large dose ofl-dopa does produce an awakening response in reserpinized mice To a less extent,m-tyrosme appears to have a similar effect The two isomers of dopa ando-tyrosine, however, are devoid of the activating property) Other epmephrine precursors, except norepinephrine, are virtually inert This study was devised to determine whether the epmephrine precursors ( phenylalanine derivatives ) as well as tyramine, methyldopate, and amphetamme produce an alerting response and increased motor activity in rats deprived of extrinsic stimulation Before and following intraperitoneal injection of the test drugs, rats were placed individually in a transparent box that was mounted on a weighing scale and attached to a recording apparatus which inscriped on paper even the slightest movement of the rat All of the catecholamine precursors studied produced some alterations in the spontaneous activity of the :ratsdl-Dopa caused the greatest increase in motor activity, the reaction being quantitatively similar to that seen with amphetaminel- Tyrosine,m-tyrosine, tyramine, and dopamine produced a peculiar effect on the rats—they appeared as if they were under the influence of a potent sedative, but they had numerous aperiodic startle movements Which, on the recording, appeared as if they had a substantial alerting reaction Although the activity tracing for amphetamine and dopa appeared similar, the rats appeared quite different on direct observation Dopa produced an increase in motor activity which appeared co-ordinated and purposeful, whereas amphetamine caused an increase in co-ordinated movements but there was also a generalized increase in body movement that resembled muscle trembling, similar to that seen in nicotine poisoning The effect ofm-tyrosme, dopa, methyldopate, and amphetamine given 20 minutes before or simultaneously with methohexital anaesthesia revealed, contrary to expectation, that hypnosis was uniformly prolonged with each, except with amphetamine These data were interpreted as contradicting the opinion that the psychomotor effects of the catecholamine precursors can be considered in the same category as epmephnne It was also evident that amphetamine acts quite differently from the precursors of epmephnne, whereas methyldopate either suppresses motor activity or has very little activity in this regard" @default.
• W2056051671 created "2016-06-24" @default.
• W2056051671 creator A5011761149 @default.
• W2056051671 creator A5042271828 @default.
• W2056051671 creator A5083859778 @default.
• W2056051671 date "1965-03-01" @default.
• W2056051671 modified "2023-10-07" @default.
• W2056051671 title "Effect of catecholamine precursors and phenylethylamines on spontaneous activity and on the response to methohexital anaesthesia" @default.
• W2056051671 cites W1712241900 @default.
• W2056051671 cites W1859533288 @default.
• W2056051671 cites W1983689043 @default.
• W2056051671 cites W1993153204 @default.
• W2056051671 cites W2011614524 @default.
• W2056051671 cites W2016324164 @default.
• W2056051671 cites W2017203469 @default.
• W2056051671 cites W2022054381 @default.
• W2056051671 cites W2023684342 @default.
• W2056051671 cites W2085518524 @default.
• W2056051671 cites W2093461586 @default.
• W2056051671 cites W2110298989 @default.
• W2056051671 cites W2132678387 @default.
• W2056051671 cites W2154204677 @default.
• W2056051671 cites W2170166219 @default.
• W2056051671 cites W2221831517 @default.
• W2056051671 cites W2255157304 @default.
• W2056051671 cites W2258667428 @default.
• W2056051671 cites W2264106490 @default.
• W2056051671 cites W2271875845 @default.
• W2056051671 cites W2289831106 @default.
• W2056051671 cites W2325702532 @default.
• W2056051671 cites W2412731213 @default.
• W2056051671 cites W2417468686 @default.
• W2056051671 cites W2420696468 @default.
• W2056051671 cites W3103919983 @default.
• W2056051671 cites W3142640776 @default.
• W2056051671 cites W4211249742 @default.
• W2056051671 doi "https://doi.org/10.1007/bf03004089" @default.
• W2056051671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14311659" @default.
• W2056051671 hasPublicationYear "1965" @default.
• W2056051671 type Work @default.
• W2056051671 sameAs 2056051671 @default.
• W2056051671 citedByCount "2" @default.
• W2056051671 crossrefType "journal-article" @default.
• W2056051671 hasAuthorship W2056051671A5011761149 @default.
• W2056051671 hasAuthorship W2056051671A5042271828 @default.
• W2056051671 hasAuthorship W2056051671A5083859778 @default.
• W2056051671 hasBestOaLocation W20560516711 @default.
• W2056051671 hasConcept C126322002 @default.
• W2056051671 hasConcept C134018914 @default.
• W2056051671 hasConcept C15744967 @default.
• W2056051671 hasConcept C158453852 @default.
• W2056051671 hasConcept C169760540 @default.
• W2056051671 hasConcept C170493617 @default.
• W2056051671 hasConcept C185592680 @default.
• W2056051671 hasConcept C24998067 @default.
• W2056051671 hasConcept C2775859304 @default.
• W2056051671 hasConcept C2775894120 @default.
• W2056051671 hasConcept C2776077682 @default.
• W2056051671 hasConcept C2777842393 @default.
• W2056051671 hasConcept C36951298 @default.
• W2056051671 hasConcept C42219234 @default.
• W2056051671 hasConcept C71924100 @default.
• W2056051671 hasConceptScore W2056051671C126322002 @default.
• W2056051671 hasConceptScore W2056051671C134018914 @default.
• W2056051671 hasConceptScore W2056051671C15744967 @default.
• W2056051671 hasConceptScore W2056051671C158453852 @default.
• W2056051671 hasConceptScore W2056051671C169760540 @default.
• W2056051671 hasConceptScore W2056051671C170493617 @default.
• W2056051671 hasConceptScore W2056051671C185592680 @default.
• W2056051671 hasConceptScore W2056051671C24998067 @default.
• W2056051671 hasConceptScore W2056051671C2775859304 @default.
• W2056051671 hasConceptScore W2056051671C2775894120 @default.
• W2056051671 hasConceptScore W2056051671C2776077682 @default.
• W2056051671 hasConceptScore W2056051671C2777842393 @default.
• W2056051671 hasConceptScore W2056051671C36951298 @default.
• W2056051671 hasConceptScore W2056051671C42219234 @default.
• W2056051671 hasConceptScore W2056051671C71924100 @default.
• W2056051671 hasIssue "2" @default.
• W2056051671 hasLocation W20560516711 @default.
• W2056051671 hasLocation W20560516712 @default.
• W2056051671 hasOpenAccess W2056051671 @default.
• W2056051671 hasPrimaryLocation W20560516711 @default.
• W2056051671 hasRelatedWork W1928101899 @default.
• W2056051671 hasRelatedWork W2032117037 @default.
• W2056051671 hasRelatedWork W2053581632 @default.
• W2056051671 hasRelatedWork W2060199686 @default.
• W2056051671 hasRelatedWork W2068000835 @default.
• W2056051671 hasRelatedWork W2069327413 @default.
• W2056051671 hasRelatedWork W2170773277 @default.
• W2056051671 hasRelatedWork W2313563427 @default.
• W2056051671 hasRelatedWork W2411806376 @default.
• W2056051671 hasRelatedWork W2748952813 @default.
• W2056051671 hasVolume "12" @default.
• W2056051671 isParatext "false" @default.
• W2056051671 isRetracted "false" @default.
• W2056051671 magId "2056051671" @default.
• W2056051671 workType "article" @default.