FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056095441> ?p ?o ?g. }

• W2056095441 endingPage "74" @default.
• W2056095441 startingPage "73" @default.
• W2056095441 abstract "To the Editor[colon] Febrile episodes are frequently encountered during the chemotherapy course, especially with neutropenia, but it is not always easy to evaluate the cause of fever. Fever induced by vincristine (VCR) is well known, but its pathophysiology is poorly understood. We describe here a case of VCR-induced fever, in which cellular hypersensitivity to VCR was demonstrated by leukocyte migration test (LMT). Fever repeatedly occurred after combination chemotherapy including VCR in a 2-year-old boy with advanced rhabdomyosarcoma, and it also occurred after a single administration of VCR. There were no other clinical symptoms except for fever, and laboratory tests showed normal findings. Fever resolved spontaneously within 24 hours without any antibiotics. The course with chemotherapy that consisted of cisplatin and actinomycin D was uneventful. The course with prophylactic administration of hydrocortisone just before VCR administration was also uneventful. These clinical observations suggested that an allergic response to VCR might be involved in the pathophysiology of fever. Leukocyte migration testing was performed according to the manner previously reported with a slight modification (1). The results of LMT are provided in Table 1. Migration index with VCR concentration of 2.5ng/mL and the patient's serum were significantly higher than that of normal controls (P [lt] 0.01). The LMT was considered positive at this concentration, and high migration index was interpreted as indicating the detection of leukocyte migration activating factor. Lymphocyte stimulation test with VCR was negative, with a stimulation index of 102[percnt].TABLE 1: Results of leukocyte migration testThe LMT is one of the sensitive tests for the detection of delayed type hypersensitivity (1). Concerning this method, Uno et al. (2,3) speculated that lymphocytes cultured with a stimulator secreted some cytokines in the culture medium, and the cytokines could inhibit or enhance the migration of human leukocytes (granulocytes). It may be considered that a hypersensitive reaction was reduced in the bioassay, such as LMT or lymphocyte stimulation test with cytotoxic drugs. However, in this case, leukocyte migration was enhanced despite the presence of VCR in the supernatant fluid. These findings indicated the possible involvement of cell-mediated hypersensitivity to VCR in the pathophysiology of fever in this patient. Only LMT with the patient's serum revealed a positive result. Because VCR is of relatively low molecular weight (923.05), it may be combined with some substances in the serum and form a complete antigen capable of stimulating lymphocytes. Ishii (4) reported that VCR-induced fever was observed in 9 of 31 children undergoing maintenance chemotherapy for leukemia or lymphoma. They also reported that the duration of fever was more prolonged during a chemotherapy course without corticosteroids than in those with corticosteroids, suggesting the possible involvement of an allergic mechanism. To our best knowledge, this is the first case of cellular hypersensitivity to VCR in VCR-induced fever. Fujimori (5) reported a case of hypersensitivity pneumonitis, in which delayed type hypersensitivity to paclitaxel was demonstrated by LMT. Leukocyte migration testing may be useful for the detection of cellular hypersensitivity to other cytotoxic drugs. In evaluating the cause of fever in patients with chemotherapy including VCR, physicians should pay attention to the possible involvement of an allergic mechanism. Chihaya Imai M.D. Katsuji Uno Ph.D. Toshio Kakihara M.D., Ph.D. Atsushi Tanaka M.D., Ph.D. Makoto Uchiyama M.D., Ph.D." @default.
• W2056095441 created "2016-06-24" @default.
• W2056095441 creator A5013862834 @default.
• W2056095441 creator A5045696383 @default.
• W2056095441 creator A5060539868 @default.
• W2056095441 creator A5078761978 @default.
• W2056095441 creator A5088726627 @default.
• W2056095441 date "2001-01-01" @default.
• W2056095441 modified "2023-09-30" @default.
• W2056095441 title "Vincristine-induced Fever in a Child With Rhabdomyosarcoma: Cellular Hypersensitivity to Vincristine Demonstrated by Leukocyte Migration Test" @default.
• W2056095441 cites W2040160629 @default.
• W2056095441 cites W2041730184 @default.
• W2056095441 cites W2112917693 @default.
• W2056095441 doi "https://doi.org/10.1097/00043426-200101000-00020" @default.
• W2056095441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11196280" @default.
• W2056095441 hasPublicationYear "2001" @default.
• W2056095441 type Work @default.
• W2056095441 sameAs 2056095441 @default.
• W2056095441 citedByCount "5" @default.
• W2056095441 countsByYear W20560954412013 @default.
• W2056095441 countsByYear W20560954412017 @default.
• W2056095441 countsByYear W20560954412022 @default.
• W2056095441 crossrefType "journal-article" @default.
• W2056095441 hasAuthorship W2056095441A5013862834 @default.
• W2056095441 hasAuthorship W2056095441A5045696383 @default.
• W2056095441 hasAuthorship W2056095441A5060539868 @default.
• W2056095441 hasAuthorship W2056095441A5078761978 @default.
• W2056095441 hasAuthorship W2056095441A5088726627 @default.
• W2056095441 hasConcept C126322002 @default.
• W2056095441 hasConcept C142724271 @default.
• W2056095441 hasConcept C203014093 @default.
• W2056095441 hasConcept C2776694085 @default.
• W2056095441 hasConcept C2776755627 @default.
• W2056095441 hasConcept C2777063308 @default.
• W2056095441 hasConcept C2778256501 @default.
• W2056095441 hasConcept C2779429289 @default.
• W2056095441 hasConcept C2780844630 @default.
• W2056095441 hasConcept C71924100 @default.
• W2056095441 hasConcept C98274493 @default.
• W2056095441 hasConceptScore W2056095441C126322002 @default.
• W2056095441 hasConceptScore W2056095441C142724271 @default.
• W2056095441 hasConceptScore W2056095441C203014093 @default.
• W2056095441 hasConceptScore W2056095441C2776694085 @default.
• W2056095441 hasConceptScore W2056095441C2776755627 @default.
• W2056095441 hasConceptScore W2056095441C2777063308 @default.
• W2056095441 hasConceptScore W2056095441C2778256501 @default.
• W2056095441 hasConceptScore W2056095441C2779429289 @default.
• W2056095441 hasConceptScore W2056095441C2780844630 @default.
• W2056095441 hasConceptScore W2056095441C71924100 @default.
• W2056095441 hasConceptScore W2056095441C98274493 @default.
• W2056095441 hasIssue "1" @default.
• W2056095441 hasLocation W20560954411 @default.
• W2056095441 hasLocation W20560954412 @default.
• W2056095441 hasOpenAccess W2056095441 @default.
• W2056095441 hasPrimaryLocation W20560954411 @default.
• W2056095441 hasRelatedWork W1494946180 @default.
• W2056095441 hasRelatedWork W2019852837 @default.
• W2056095441 hasRelatedWork W2022490316 @default.
• W2056095441 hasRelatedWork W2050997721 @default.
• W2056095441 hasRelatedWork W2072765345 @default.
• W2056095441 hasRelatedWork W2412245030 @default.
• W2056095441 hasRelatedWork W2418393430 @default.
• W2056095441 hasRelatedWork W2523027258 @default.
• W2056095441 hasRelatedWork W3134307504 @default.
• W2056095441 hasRelatedWork W4289968232 @default.
• W2056095441 hasVolume "23" @default.
• W2056095441 isParatext "false" @default.
• W2056095441 isRetracted "false" @default.
• W2056095441 magId "2056095441" @default.
• W2056095441 workType "article" @default.