Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056100594> ?p ?o ?g. }
- W2056100594 endingPage "252" @default.
- W2056100594 startingPage "239" @default.
- W2056100594 abstract "The LIN-35 retinoblastoma protein homolog and the ubiquitin-conjugating enzyme UBC-18 function redundantly to control an early step of pharyngeal morphogenesis in C. elegans. In order to identify ubiquitin-ligases acting downstream of UBC-18, we carried out a two-hybrid screen using UBC-18 as the bait molecule. Our screen identified three putative ubiquitin-ligases, one of which, ARI-1, showed genetic interactions leading to defective pharyngeal development that were identical to that previously observed for UBC-18. ARI-1 is a member of the RBR family of ubiquitin-ligases and contains a C-terminal motif that places it within the highly conserved Ariadne subfamily of RBR ligases. Our analyses indicate that ARI-1 is the principal Ariadne family member in C. elegans that is involved in the control of pharyngeal development with UBC-18. Using GFP reporters, we find that ARI-1 is expressed dynamically in a wide range of tissues including muscles and neurons during embryonic and postembryonic development. We also provide evidence that dsRNA species containing 14 or fewer base pairs of contiguous identity with closely related mRNAs are sufficient to mediate off-target silencing in C. elegans." @default.
- W2056100594 created "2016-06-24" @default.
- W2056100594 creator A5002016851 @default.
- W2056100594 creator A5073102971 @default.
- W2056100594 date "2006-03-01" @default.
- W2056100594 modified "2023-10-14" @default.
- W2056100594 title "ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans" @default.
- W2056100594 cites W1497941038 @default.
- W2056100594 cites W1550876205 @default.
- W2056100594 cites W1647075334 @default.
- W2056100594 cites W1832030339 @default.
- W2056100594 cites W1852163795 @default.
- W2056100594 cites W1877873625 @default.
- W2056100594 cites W1911220294 @default.
- W2056100594 cites W1923404825 @default.
- W2056100594 cites W1964021682 @default.
- W2056100594 cites W1966936049 @default.
- W2056100594 cites W1974643603 @default.
- W2056100594 cites W1988031203 @default.
- W2056100594 cites W2003343630 @default.
- W2056100594 cites W2007962912 @default.
- W2056100594 cites W2009417817 @default.
- W2056100594 cites W2012910673 @default.
- W2056100594 cites W2013558716 @default.
- W2056100594 cites W2013599007 @default.
- W2056100594 cites W2013740116 @default.
- W2056100594 cites W2016147336 @default.
- W2056100594 cites W2016766601 @default.
- W2056100594 cites W2017642141 @default.
- W2056100594 cites W2028919524 @default.
- W2056100594 cites W2035722905 @default.
- W2056100594 cites W2036058336 @default.
- W2056100594 cites W2038492783 @default.
- W2056100594 cites W2045449473 @default.
- W2056100594 cites W2050836489 @default.
- W2056100594 cites W2052779687 @default.
- W2056100594 cites W2055420305 @default.
- W2056100594 cites W2060552444 @default.
- W2056100594 cites W2063090066 @default.
- W2056100594 cites W2070564266 @default.
- W2056100594 cites W2080853928 @default.
- W2056100594 cites W2082040415 @default.
- W2056100594 cites W2086085166 @default.
- W2056100594 cites W2088629534 @default.
- W2056100594 cites W2088966640 @default.
- W2056100594 cites W2101276421 @default.
- W2056100594 cites W2103022330 @default.
- W2056100594 cites W2109816088 @default.
- W2056100594 cites W2115086628 @default.
- W2056100594 cites W2117753542 @default.
- W2056100594 cites W2119327651 @default.
- W2056100594 cites W2120886143 @default.
- W2056100594 cites W2122163057 @default.
- W2056100594 cites W2127830527 @default.
- W2056100594 cites W2128491398 @default.
- W2056100594 cites W2129473323 @default.
- W2056100594 cites W2133799617 @default.
- W2056100594 cites W2134163254 @default.
- W2056100594 cites W2142305917 @default.
- W2056100594 cites W2143221267 @default.
- W2056100594 cites W2150123812 @default.
- W2056100594 cites W2154166273 @default.
- W2056100594 cites W2154880177 @default.
- W2056100594 cites W2162611989 @default.
- W2056100594 cites W2163336334 @default.
- W2056100594 cites W2163538728 @default.
- W2056100594 cites W2165684064 @default.
- W2056100594 cites W2166903671 @default.
- W2056100594 cites W2168051144 @default.
- W2056100594 doi "https://doi.org/10.1016/j.ydbio.2005.11.045" @default.
- W2056100594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16457801" @default.
- W2056100594 hasPublicationYear "2006" @default.
- W2056100594 type Work @default.
- W2056100594 sameAs 2056100594 @default.
- W2056100594 citedByCount "27" @default.
- W2056100594 countsByYear W20561005942012 @default.
- W2056100594 countsByYear W20561005942013 @default.
- W2056100594 countsByYear W20561005942014 @default.
- W2056100594 countsByYear W20561005942016 @default.
- W2056100594 countsByYear W20561005942017 @default.
- W2056100594 countsByYear W20561005942018 @default.
- W2056100594 countsByYear W20561005942020 @default.
- W2056100594 countsByYear W20561005942022 @default.
- W2056100594 crossrefType "journal-article" @default.
- W2056100594 hasAuthorship W2056100594A5002016851 @default.
- W2056100594 hasAuthorship W2056100594A5073102971 @default.
- W2056100594 hasBestOaLocation W20561005941 @default.
- W2056100594 hasConcept C104317684 @default.
- W2056100594 hasConcept C119056186 @default.
- W2056100594 hasConcept C134459356 @default.
- W2056100594 hasConcept C25602115 @default.
- W2056100594 hasConcept C2778944004 @default.
- W2056100594 hasConcept C2908868211 @default.
- W2056100594 hasConcept C50929876 @default.
- W2056100594 hasConcept C54355233 @default.
- W2056100594 hasConcept C86803240 @default.
- W2056100594 hasConcept C95444343 @default.
- W2056100594 hasConceptScore W2056100594C104317684 @default.