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• W2056104649 abstract "Summary Aberrant immunity response contributes to the pathogenesis of acute‐on‐chronic hepatitis B liver failure. Tumour necrosis factor‐α‐induced protein‐8 like‐2 ( TIPE 2) is a recently identified molecular to maintain immune homoeostasis, but its role in acute‐on‐chronic hepatitis B liver failure ( ACHBLF ) is unknown. We detected TIPE 2 m RNA levels in peripheral blood mononuclear cells ( PBMC s) from 56 patients with ACHBLF, 60 chronic hepatitis B patients, 24 healthy controls and analysed its role in disease severity and prognosis. TIPE 2 m RNA expression in patients with ACHBLF was higher than that of patients with chronic infection or healthy controls. In patients with ACHBLF, TIPE 2 m RNA level was positively correlated with serum total bilirubin, international normalized ratio and model for end‐stage liver disease scores. Furthermore, the level of TIPE 2 m RNA was significantly higher in nonsurvivors than survivors in patients with ACHBLF. The m RNA level of TIPE 2 gradually decreased week by week in survivors accompanied by recovery from patients with ACHBLF, while its expression sustained at high levels in nonsurvivors. TIPE 2 m RNA level after lipopolysaccharide ( LPS ) stimulation ex vivo in patients with ACHBLF was higher compared with controls and patients with chronic infection. Meanwhile, cytokines ex vivo secreted were measured as a marker of immune activation. After LPS stimulation, interleukin (IL)‐6 and tumour necrosis factor (TNF)‐α m RNA expression were reduced in patients with ACHBLF, and a significantly negative correlation was found between TIPE 2 and TNF ‐α m RNA levels. In conclusion, our results identified the potential role of TIPE 2 in predicting disease progression and prognosis in patients with ACHBLF by negative regulating of cell‐mediated immunity." @default.
• W2056104649 created "2016-06-24" @default.
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• W2056104649 date "2013-05-16" @default.
• W2056104649 modified "2023-10-16" @default.
• W2056104649 title "Elevated expression of tumour necrosis factor-α-induced protein 8 (TNFAIP8)-like 2 mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure" @default.
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• W2056104649 doi "https://doi.org/10.1111/jvh.12116" @default.
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