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- W2056119027 abstract "We have investigated intranasal delivery of novel vaccines for plague, based on poly- l -lactide (PLLA) microencapsulated recombinant V antigen (rV) of Yersinia pestis . Microspheres containing rV alone or co-encapsulated with the cytokines IFN-γ, IL-4 or IL-6 were administered in a two-dose regimen and antibody responses and protective efficacy were monitored. All treatment groups stimulated high rV-specific antibody titres in serum, predominantly of the IgG1 isotype, which were maintained over several months. There was evidence of both IgG and IgA responses in lung samples from all groups. Formulations based on rV antigen alone or rV co-encapsulated with IL-6 provided complete protection against systemic challenge with Y. pestis strain GB; however protective efficacy was impaired by co-encapsulating either IFN-γ or IL-4 with rV." @default.
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- W2056119027 date "2002-11-01" @default.
- W2056119027 modified "2023-09-26" @default.
- W2056119027 title "Protection against plague following immunisation with microencapsulated V antigen is reduced by co-encapsulation with IFN-γ or IL-4, but not IL-6" @default.
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- W2056119027 doi "https://doi.org/10.1016/s0264-410x(02)00396-1" @default.
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