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- W2056127561 abstract "Anterior mitral leaflet stiffness during isovolumic contraction (IVC) is much greater than that during isovolumic relaxation (IVR). We have hypothesized that this stiffening is due to transient early systolic force development in the slip of cardiac myocytes in the annular third of the anterior leaflet. Because the atrium is excited before IVC and leaflet myocytes contract for ≤250 ms, this hypothesis predicts that IVC leaflet stiffness will drop to near-IVR values in the latter half of ventricular systole. We tested this prediction using radiopaque markers and inverse finite element analysis of 30 beats in 10 ovine hearts. For each beat, circumferential ( E c ) and radial ( E r ) stiffness was determined during IVC (Δ t 1 ), end IVC to midsystole (Δ t 2 ), midsystole to IVR onset (Δ t 3 ), and IVR (Δ t 4 ). Group mean stiffness ( E c ± SD; E r ± SD; in N/mm 2 ) during Δ t 1 (44 ± 16; 15 ± 4) was 1.6–1.7 times that during Δ t 4 (28 ± 11; 9 ± 3); Δ t 2 stiffness (39 ± 15; 14 ± 4) was 1.3–1.5 times that of Δ t 4 , but Δ t 3 stiffness (32 ± 12; 11 ± 3) was only 1.1–1.2 times that of Δ t 4 . The stiffness drop during Δ t 3 supports the hypothesis that anterior leaflet stiffening during IVC arises primarily from transient force development in leaflet cardiac myocytes, with stiffness reduced as this leaflet muscle relaxes in the latter half of ventricular systole." @default.
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- W2056127561 date "2010-06-01" @default.
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- W2056127561 title "Transient stiffening of mitral valve leaflets in the beating heart" @default.
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- W2056127561 doi "https://doi.org/10.1152/ajpheart.00215.2010" @default.
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