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- W2056131194 abstract "The short- and long-term effects of neuroleptic drugs differ both clinically and biochemically. Short-term treatment with such a drug causes a kinetic activation of striatal tyrosine hydroxylase. Long-term treatment causes a prompt activation of the enzyme which is followed by a delayed, compensatory deactivation below control levels. Tolerance also develops to the stimulating effect of haloperidol on striatal dopamine turnover." @default.
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- W2056131194 date "1977-07-08" @default.
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- W2056131194 title "Haloperidol: effect of long-term treatment on rat striatal dopamine synthesis and turnover" @default.
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- W2056131194 doi "https://doi.org/10.1126/science.17917" @default.
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