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- W2056131299 abstract "Significance The mammalian intestine provides a key interface with several essential environmental factors, including nutrients, toxins, resident microbiota, and pathogens. Consequently, the intestine undergoes major developmental transitions that correspond to dramatic changes in the environment: one at birth and the other at weaning. These transitions reflect both developmental and environmentally induced changes in intestinal gene expression. Here, we performed a systematic analysis of global gene expression that is associated with developmental timing versus the changes that are due to the innate immune signaling pathways mediated by toll-like receptor (TLR) and IL-1 receptor families. The results reveal distinct roles of these pathways in intestinal adaptation throughout postnatal development." @default.
- W2056131299 created "2016-06-24" @default.
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- W2056131299 date "2015-02-10" @default.
- W2056131299 modified "2023-09-27" @default.
- W2056131299 title "Analysis of gene–environment interactions in postnatal development of the mammalian intestine" @default.
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- W2056131299 doi "https://doi.org/10.1073/pnas.1424886112" @default.
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