Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056133362> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2056133362 endingPage "888" @default.
- W2056133362 startingPage "883" @default.
- W2056133362 abstract "Melanoma antigen-encoding gene (MAGE-1) has been introduced as a sensitive immunohistochemical marker to aid in the diagnosis of malignant melanomas, in particular, those that are HMB-45 negative. Our goal was to determine the consistency of positive staining in melanomas on the basis of the usefulness of MAGE-1 in comparison with tyrosinase and MART-1. We studied 56 malignant melanomas using immunohistochemical markers to MAGE-1, tyrosinase, MART-1, HMB-45, and S-100. Six of 17 HMB-45-negative cases were strongly positive for MAGE-1 (35%), while 9 of 39 HMB-45-positive cases were positive for MAGE-1 (23%), overall, 27% positivity (n = 56). Tyrosinase and MART-1 were both strongly positive in 42 of 56 cases (75%). Fifty-two of 56 cases were strongly positive for S-100 (93%). We found MAGE-1 to be less sensitive than described in other studies, and overall, not very helpful, especially as a predictor of aggressive behavior. Although MAGE-1 expression has been considered as a target for immunomodulation therapy, our findings do not indicate consistent expression of this epitope in a majority of melanomas. S-100 protein, tyrosinase, and MART-1 immunomarkers were more frequently positive in our melanoma cases and appear to constitute a useful panel of markers to aid in the diagnosis of metastatic malignant melanomas, especially in patients with an unknown primary." @default.
- W2056133362 created "2016-06-24" @default.
- W2056133362 creator A5036083719 @default.
- W2056133362 creator A5036885694 @default.
- W2056133362 creator A5080451117 @default.
- W2056133362 date "2004-07-01" @default.
- W2056133362 modified "2023-09-23" @default.
- W2056133362 title "Is MAGE-1 Expression in Metastatic Malignant Melanomas Really Helpful?" @default.
- W2056133362 cites W1503004495 @default.
- W2056133362 cites W1968508810 @default.
- W2056133362 cites W1970692246 @default.
- W2056133362 cites W1973611974 @default.
- W2056133362 cites W1990253623 @default.
- W2056133362 cites W1994444462 @default.
- W2056133362 cites W1996926182 @default.
- W2056133362 cites W2001280122 @default.
- W2056133362 cites W2006987944 @default.
- W2056133362 cites W2013582624 @default.
- W2056133362 cites W2042116093 @default.
- W2056133362 cites W2079710223 @default.
- W2056133362 cites W2080906201 @default.
- W2056133362 cites W2088364215 @default.
- W2056133362 cites W2091972243 @default.
- W2056133362 cites W2139030523 @default.
- W2056133362 cites W53747407 @default.
- W2056133362 doi "https://doi.org/10.1097/00000478-200407000-00006" @default.
- W2056133362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15223957" @default.
- W2056133362 hasPublicationYear "2004" @default.
- W2056133362 type Work @default.
- W2056133362 sameAs 2056133362 @default.
- W2056133362 citedByCount "16" @default.
- W2056133362 countsByYear W20561333622014 @default.
- W2056133362 countsByYear W20561333622017 @default.
- W2056133362 countsByYear W20561333622019 @default.
- W2056133362 countsByYear W20561333622021 @default.
- W2056133362 crossrefType "journal-article" @default.
- W2056133362 hasAuthorship W2056133362A5036083719 @default.
- W2056133362 hasAuthorship W2056133362A5036885694 @default.
- W2056133362 hasAuthorship W2056133362A5080451117 @default.
- W2056133362 hasConcept C126322002 @default.
- W2056133362 hasConcept C142724271 @default.
- W2056133362 hasConcept C143998085 @default.
- W2056133362 hasConcept C147483822 @default.
- W2056133362 hasConcept C181199279 @default.
- W2056133362 hasConcept C195616568 @default.
- W2056133362 hasConcept C200583388 @default.
- W2056133362 hasConcept C203014093 @default.
- W2056133362 hasConcept C204232928 @default.
- W2056133362 hasConcept C2777658100 @default.
- W2056133362 hasConcept C502942594 @default.
- W2056133362 hasConcept C55493867 @default.
- W2056133362 hasConcept C71924100 @default.
- W2056133362 hasConcept C86803240 @default.
- W2056133362 hasConcept C87554066 @default.
- W2056133362 hasConceptScore W2056133362C126322002 @default.
- W2056133362 hasConceptScore W2056133362C142724271 @default.
- W2056133362 hasConceptScore W2056133362C143998085 @default.
- W2056133362 hasConceptScore W2056133362C147483822 @default.
- W2056133362 hasConceptScore W2056133362C181199279 @default.
- W2056133362 hasConceptScore W2056133362C195616568 @default.
- W2056133362 hasConceptScore W2056133362C200583388 @default.
- W2056133362 hasConceptScore W2056133362C203014093 @default.
- W2056133362 hasConceptScore W2056133362C204232928 @default.
- W2056133362 hasConceptScore W2056133362C2777658100 @default.
- W2056133362 hasConceptScore W2056133362C502942594 @default.
- W2056133362 hasConceptScore W2056133362C55493867 @default.
- W2056133362 hasConceptScore W2056133362C71924100 @default.
- W2056133362 hasConceptScore W2056133362C86803240 @default.
- W2056133362 hasConceptScore W2056133362C87554066 @default.
- W2056133362 hasIssue "7" @default.
- W2056133362 hasLocation W20561333621 @default.
- W2056133362 hasLocation W20561333622 @default.
- W2056133362 hasOpenAccess W2056133362 @default.
- W2056133362 hasPrimaryLocation W20561333621 @default.
- W2056133362 hasRelatedWork W12457287 @default.
- W2056133362 hasRelatedWork W1508383316 @default.
- W2056133362 hasRelatedWork W1972362145 @default.
- W2056133362 hasRelatedWork W2008481914 @default.
- W2056133362 hasRelatedWork W2057663047 @default.
- W2056133362 hasRelatedWork W2144740294 @default.
- W2056133362 hasRelatedWork W2518421251 @default.
- W2056133362 hasRelatedWork W2745389321 @default.
- W2056133362 hasRelatedWork W4225261973 @default.
- W2056133362 hasRelatedWork W4303614250 @default.
- W2056133362 hasVolume "28" @default.
- W2056133362 isParatext "false" @default.
- W2056133362 isRetracted "false" @default.
- W2056133362 magId "2056133362" @default.
- W2056133362 workType "article" @default.